Humans ; Vitamin D ; Vitamin D Deficiency

Humans ; Vitamin D ; Vitamin D Deficiency

Objectives: This study aimed to compare the severity of COVID-19, inflammatory parameters and clinical outcomes among patients with normal and subnormal levels of Vitamin D. Methodology: This is a retrospective cohort study of 135 patients admitted in a tertiary hospital for COVID-19. Patients were grouped according to their Vitamin D level. Primary outcome measure was the composite of all-cause mortality and morbidity. Other outcome measures determined were the comparison among the groups on the severity of COVID-19 infection, changes in inflammatory parameters, length of hospital stay and duration of respiratory support. Results: There was a significant trend of higher ICU admission (p=0.024), mortality (p=0.006) and poor clinical outcome (p=0.009) among the Vitamin D deficient group. No significant difference was found for most of the inflammatory parameters, duration of hospital stay and respiratory support. Overall, patients with deficient, but not insufficient Vitamin D level had 6 times higher odds of composite poor outcome than those with normal Vitamin D (crude OR=5.18, p=0.003; adjusted OR=6.3, p=0.043). Conclusion The inverse relationship between Vitamin D level and poor composite outcome observed in our study suggests that low Vitamin D may be a risk factor for poor prognosis among patients admitted for COVID-19.
Vitamin D ; Vitamin D Deficiency ; COVID-19

No abstract available.
Vitamin D* ; Vitamins*

No abstract available.
Vitamin D ; Vitamins

No abstract available.
Vitamin D* ; Vitamins*

The study built process of extraction vitamin D3 in Patarvit syrup by SPE technique with mean extract performance as 98.2%. Chromatography was built to quantity vitamin D3 as following: Lichrosorb RP 18 column (250 X 4 mm, 5 and 10µm ); Detector UV: 265 nm; movement phase: Methanol-ethyl acetate - water (90:7:3); stream speed: 1.5ml/minute. Injection volume: 20µl. The method had a high accuracy (E% = 1.18%). Percentage of withdrawal was 96.8% with E% = 0.71%; the limit of detection (LOD) was 5.79IU/ml, the limit of quantitative (LOQ) was 19.3IU/ml
Vitamin D ; Pharmaceutical Preparations

Vitamin D has been the focus of much scientific literature in recent years owing to various studies showing its association with a wide variety of pathological conditions 1,2 . Sun exposure, diet and fortified supplementation account for a bulk of Vitamin D intake in humans. Activation of vitamin D is sequential and requires sun exposure for conversion of 7- dehydrocholesterol to Vitamin D3. Further metabolism in the liver converts Vitamin D3 to 25 –hydroxyvitamin D3. Conversion to its active form 1,25 dihydroxyvitamin D3 (Calcitriol) occurs in the kidneys 2 . The importance of Vitamin D in calcium metabolism and bone health is well known and documented. Controversies exist regarding the true prevalence of hypovitaminosis, however in developing countries the prevalence of vitamin D deficiency in all age groups is probably higher 3 . Adding to this the burden and morbidity of skeletal trauma, persistent deficiency may have a deleterious effect in the injured 4, 5 . Vitamin D, with its positive effect on bone health does play a role in the biology of fracture repair and remodelling 6 . The role of Vitamin D replacement as sole biological effectors in fracture repair may be difficult to quantify and confounded by other variables at play in bone healing. Studies looking at vitamin D levels in orthopaedic patients have also shown significant levels of deficiency and have put forward recommendations for evaluation and supplementation
Vitamin D Deficiency

No abstract available.
Vitamin D ; Vitamins

Low levels of serum 25(OH)D in women are reported in temperate countries, and increasingly so in tropical countries but few such studies have been reported in Indonesia. This study was aimed at assessing the serum vitamin D status and its associated factors in a sample of Indonesian women Methods: A cross-sectional study was conducted on 156 apparently healthy women during the dry season in North Sumatera. The measurements carried out included exposure to sun's rays, intake of vitamin D food sources, reported physical activity, body fatness (by bioelectrical impedance analysis), and serum 25(OH)D levels (by chemiluminescent immunoassay). Serum 25(OH)D levels were categorised into: deficient(<20 ng/mL), insufficient (20-32 ng/mL), sufficient (32-100 ng/ mL), and normal for tropical countries (54-90 ng/mL). Statistical analysis included Pearson correlation, independent t-test, and one way ANOVA tests. Results: The mean age of the subjects was 35.6±7.7 years, with about 70% working indoors. About half of the women were obese. The majority had low vitamin D intake. More than half had sun ray exposure of less than 1 hour, and moreover, nearly two-thirds of them wore the 'hijab' that covers most parts of their body. The majority of women reported low physical activity level. The mean serum 25(OH)D level of the subjects was 17.71 ng/mL (95% CI: 16.22, 19.34 ng/mL). Of the total, 95% (148) were in the vitamin D deficient-insufficient category, with the remaining 5% in the sufficient category. An association was found between occupation, dietary intake of vitamin D, sun ray exposure, and physical activity levels with serum vitamin D concentrations. Conclusion: The results showed that vitamin D deficiency can occur in women living in a tropical country if they have sun-avoiding lifestyles, work indoors, and have low dietary intake of vitamin D.
Vitamin D ; Women ; Indonesia