No abstract available.
Hand* ; Hyperpigmentation* ; Vitamin B 12 Deficiency* ; Vitamin B 12* ; Vitamins*

No abstract available.
Anemia* ; Gastrectomy* ; Vitamin B 12 Deficiency* ; Vitamin B 12* ; Vitamins*

Vitamin B12 deficiency in exclusively breastfed infants is an important problem in developing countries. Vitamin B12 deficiency is associated with a wide spectrum of clinical manifestations. Few cases of vitamin B12 deficiency have been reported as the cause of infantile spasms. We report the case of a 6-month-old boy diagnosed with infantile spasms associated with vitamin B12 deficiency caused by nutritional inadequacy in the mother. He was observed to have head nods and flexor limbs spasms which appeared in clusters. Psychomotor development was normal. The serum vitamin B12 level was low and results of electroencephalography (EEG) indicated modified hypsarrhythmia. His symptoms resolved after synthetic adrenocorticotropic hormone (ACTH) and vitamin B12 treatment. The EEG was completely normal after the first month and sixth month of treatment. In addition to ACTH and vitamin B12 treatment, following antiepileptic drug treatment was not initiated. During 21 months’ follow up he is seizure-free and his neurological development is age-appropriate. This case of a 6 month-old infant with infantile spasms due to vitamin B12 deficiency seems to be a striking because of only with vitamin B12 and ACTH treatment the patient became seizure-free. Vitamin B12 deficiency may be a treatable cause of infantile spasms and should be considered in the associated cause of infantile spasms especially if nutritional inadequacy in the mother.
Vitamin B 12 Deficiency ; Infants

95 patients in Sorokdo national hospital injected 1-5mg Hydroxocobalamin (5mg/2ml/1ample) in 5-7 days/week, duration 6.4 months, average age 71.6 years old. Effects are 1) softening of hand movement(22/95), early effect, 2) improving of motor function (8/95) 3) sensory function(8/95) 4) sweating (3/95) 5) neuropathic pain and headache(neuralgia-like) (7/95) 6) jaw and hand tremor (7/95) 7) no response (41/95) 8) side effect (1/95) Leprosy is demyelinating peripheral neuropathy, Vitamin B12 effects on myelin, but unkown it's mechnism. Vitamin B12 improve nerve function impairments in leprosy, especially neuropathic pain and tremor, which lead to deformities and disabilities.
Congenital Abnormalities ; Hand ; Humans ; Hydroxocobalamin ; Jaw ; Leprosy ; Myelin Sheath ; Neuralgia ; Peripheral Nervous System Diseases ; Sweat ; Sweating ; Tremor ; Vitamin B 12

No abstract available.
Anemia, Megaloblastic ; Anemia, Pernicious* ; Vitamin B 12

No abstract available.
Humans ; Subacute Combined Degeneration ; Vitamin B 12

No abstract available.
Anemia, Pernicious ; Humans ; Vitamin B 12 ; Vitamins

Background: Vitamin B12 is one of the common drugs used by physicians to treat peripheral neuropathy (PN), although many patients have a good response, however, overdose and toxicity aggravate the condition and worsen the patient’s symptoms. The purpose of this paper is to highlight association between Vitamin B12 toxicity and deterioration of PN symptoms. Case Summary: An elder Sudanese man with acute onset of sensory PN, the patient’s symptoms started by tingling sensations and paresthesia affecting both hands and feet. After patient received cobalamin (vitamin B 12) prescribed by his doctor, the patient symptoms were markedly aggravated and his condition worsened to extend that impaired the normal patient ordinary work. No symptoms related to motor system. Other possible etiologies were studied and excluded. Investigations of his condition revealed blood level of B12 was 1900 pg/mL, the patient condition improved dramatically with discontinuation of the drug. Conclusion Cobalamin toxicity aggravate sensory PN symptoms. Clinicians are advised to adjust the dose and check Cobalamin level before and during treatment to avoid its toxicity.
Peripheral Nervous System Diseases ; Vitamin B 12

PURPOSE: The most common metabolic defect appearing following a gastrectomy is anemia. Two types have been identified: One is related to a deficiency in iron and the other is related to an impairment in vitamin B12 metabolism. The purpose of this study is to evaluate the incidence and treatment of vitamin B12 deficiency after a total gastrectomy. MATERIALS AND METHODS: Serum vitamin B12 concentrations were measured in 128 patients who had undergone a total gastrectomy. The group with a serum concentration under 200 pg/ml was supplemented at one-month intervals with Actinamide and five-six months later, serum concentrations of the vitamin B12 were rechecked. RESULTS: The group with vitamin B12 under 200 pg/ml was 61 (47.6%) of the 128 patients who had undergone a total gastrectomy. In this group, the cumulative incidences of vitamin B12 deficiency were 7.0, 23.4, 33.6, 39.1, 41.4, and 47.7% at 6 months, 1, 2, 3, 4, and 5 or more years, respectively. The treated group with vitamin B12 under 200 pg/ml had 36 (28.17%) of the 128 patients. The 16 of those cases with vitamin B12 levels of 100~150 pg/ml were supplemented 5.21 times and the vitamine B12 was elevated to above 650 pg/ml. The other 20 cases with an average of vitamin B12 levels of 150~200 pg/ml were supplemented an average of 4.75 times, and the vitamin B12 was elevated to above 780 pg/ml. CONCLUSION: It is necessary to supplement vitamin B12 even 1 year later after a total gastrectomy. The group with vitamin B12 under 200 pg/ml was supplemented 5~6 times at one-month intervals with Actinamide 1,000microgram IM injections and reached normal levels.
Anemia ; Gastrectomy* ; Humans ; Incidence ; Iron ; Metabolism ; Stomach Neoplasms* ; Vitamin B 12 Deficiency* ; Vitamin B 12* ; Vitamins*

No abstract available.
Brain* ; Cerebral Infarction ; Hyperhomocysteinemia* ; Vitamin B 12 Deficiency* ; Vitamin B 12* ; Vitamins*