Using Life-Tech instrument(Visulab 5102 recorder, 7330 black and white visual pattern stimulator, 5402A averager, and 5874 P1 preamplifier), normal VEP was measured on 49 healthy person(98 eyes) aged from 23 to 27yrs with visual acuity better than 0.9. The frequency of stimulus was 2Hz, averaged 128 responses and analysis time was 250ms. The check size was 60min horizontally and 50min vertically. The mean P1 latency of 98 eyes was 96.81 +/- 7.51ms. The mean P1 latency of 49 right eyes was 96.78 +/- 7.98ms and that of left eyes was 96.88 +/- 7.20ms. The difference between right and left eye was not significant statistically(p>0.05). The amplitide of VEP was so variable that it was excluded from this analysis.
Visual Acuity

The "reliability" of a subject's automated perimetric result is generally assessed by three measures: fixation loss, false positive and false negative rates. These reliability indicies were examined for 237 glaucomatous and ocular hypertensive eyes who for the first time underwent visual field testing (central 30-2 test on Humphrey visual field analyzer. Allergan Humphrey). Of the examination results, 11% of subjects were considered unreliable with the use of the manufacturer's reliability criteria. 71% of the unreliable results were due to failure to meet the criterion for fixation loss. The rest 29% were due to high false negative rates. After given reinstruction and more attention to fixation loss throughout the test by the technician, second visual field test was performed. On second examination, 82% of fixation loss and 71% of false negative rate was reduced.
Visual Field Tests ; Visual Fields

Central 30-2 threshold tests were performed in 124 eyes of 62 normal subjects with Humphrey Field Analyzer. The average value of foveal threshold, mean deviation(MD), pattern standard deviation(PSD), shor-term fluctuation(SF) and corrected pattern standard deviation(CPSD) were 34.3+/-2.6dB, -1.96+/-1.31dB, 2.25+/-0.88dB, 1.38+/-0.52dB and 1.41+/-1.10dB, respectively. The frequency of abnormal value on automated perimetry(p<5%) was 25.5% in foveal threshold and 19.1% in MD, which was higher than fundamental data of perimetry. As the age increased, foveal threshold decreased (r=-0.729), PSD and CPSD increased (r=0.422) and 0.385, respectively) ; these are statistically significant correlations(p<0.05). This study has the limitation that test was performed on single session and had small study group. Therefore, further study is needed with comparative analysis following repeated test and larger group of visual field examination.
Visual Field Tests ; Visual Fields*

PURPOSE: To evaluate and compare the inter-individual variability and normal limits of Humphrey SITA and Octopus TOP which were recently developed for shortening test time and decreasing the patient's fatigue. METHODS: Humphrey SITA and Octopus TOP tests were performed on 100 normal Korean subjects and their test results were analyzed. RESULTS: The average test duration was 294.02+/-29.61 seconds in SITA and 147.93+/-9.78 seconds in TOP. There was no significant difference between the two perimetric tests in MD (mean deviation), but PSD (pattern standard deviation) of TOP program was significantly higher than that of SITA (P< 0.01). Mean sensitivity of SITA was 30.15+/-1.00 dB and that of TOP was 26.79+/-1.11 dB, so mean sensitivity of SITA was about 3 dB higher than that of TOP. In topographical map, averaged threshold sensitivity decreased with the eccentricity in both perimetries. Topographically, SITA showed the more regularly increasing standard deviation of threshold sensitivity toward periphery of visual field, but TOP showed the irregular pattern of distribution of the standard deviation. Most of the subjects (88.8%) replied that they were more comfortable with the TOP than the SITA program because of the shorter test time. CONCLUSION: Inter-individual variability in the normal Korean subjects was smaller in Humphrey SITA than Octopus TOP program, but Octopus TOP had the advantage of shorter duration of the test and lower fatigue.
Fatigue ; Octopodiformes* ; Visual Field Tests* ; Visual Fields

We compared the full threshold method, central 30-2 Humphrey perimetry with a newer strategy of SITA-standard.To valuate the clinical usefulness, 30 glaucoma patients and 20 normal persons underwent both tests. MD, PSD and test time were comparatively analyzed.In glaucoma patients, the mean test time was 7 min 37 sec[+/-1 min 54sec]for the SITA-standard, while it was 14 min 55 sec[+/-1 min 58 sec]for the full threshold method.The mean value of MD were -7.62 +/-7.93 and 8.85 +/-8.19, while PSD were 5.89 +/-4.24 and 6.50 +/-4.07, repectively. In normal persons group, the mean test time was 6 min 56 sec[+/-1 min 3sec]for the SITA-standard, while it was 14 min 1 sec[+/-1 min 24 sec]for full threshold method.The mean values of the MD were -2.41 +/-0.87 and 3.00 +/-1.31, while the mean values of the PSD were 2.04 +/-0.47, 2.12 +/-0.50, respectively. In conclusion, the SITA-standard did not show any significant differences in both MD and PSD.However, the test time was reduced 49%in glaucoma patients and 53%in normal persons.Therefore, the SITA-standard exhibited similar clinical significance on both glaucoma patient and glaucoma suspect.So it was an useful and effective test to reduce test time.
Glaucoma ; Humans ; Visual Field Tests ; Visual Fields*

We quantitatively analyzed the changes of the(retinal) threshold sensitivities between normal status and dilated emmetropic status, and between dilated emmetropic status and -1.0D induced myopic status. Three consecutive visual field examinations by Humphrey Field Analyzer C-30-2 threshold test and STATPAC program were performed in 36 eyes of 21 normal subjects who ranged in age from 23 to 40 years. The results were as follows: 1) There was a statistically significant decrease (0.87 +/- 0.91dB) in the mean threshold sensitivity within the central 30 degrees at the dilated emmetropic status(27.90dB) as compared with the normal status(28.77dB) (p=0.0001). 2) There was a statistically significant decrease(0.99 +/- 0.61dB) at -1.0D induced myopic status(26.91dB) as compared with the dilated emmetropic status(27.90dB) (p=0.0001). 3) After dilation, the mean threshold sensitivity between 20 and 30 degrees of field showed statistically significant decrease as compared with thosE' within the central 20 degrees of visual field(p<0.05). In case of -1.0D induced myopia, there were uniform decrease in the mean threshold sensitivities within the central 30 degrees of visual field(p>0.05). Therefore, we emphasize the importance of consistent pupillary size and correct refractive state in performing the serial automated visual field tests.
Myopia* ; Visual Field Tests ; Visual Fields

Dynamic strategy(DS) is a fast threshold algorithm for the Octopus 101 perimeter. To analyze the efficiency of DS, we compared the results of visual field measurements using DS and conventional normal strategy(NS). Subjects comprised 60 eyes of 30 normal individuals in the 3rd decade who has not experienced perimetry before. Program G2 was performed on all subjects at random and enough intervals between the two tests(more than 1 hour). Mean testing time was 1047.63+/-219.38 seconds in NS and 684.98+/-130.95 seconds in DS. Testing time reduction rate was 32.69+/-14.35% on average. Mean defect(MD) was 2.80+/-1.02dB, 2.15+/-0.94dB in the two strategies, respectively. Corrected loss variance(CLV) was 1.31+/-0.50dB2 and 1.03+/-0.61dB2 in each test. There was significant difference in MD and CLV statistically(P<0.01). Mean short term fluctuation(SF) was 1.38+/-0.49dB and 1.45+/-0.50 dB; mean reliability factor(RF) was 2.05+/-2.73% and 1.98+/-2.80% in the two strategies, respectively. There was no significant difference in SF and RF statistically(P>0.01). It took less time with DS than NS in Octopus 101 perimeter, but further study will be needed for clinical application of DS.
Octopodiformes* ; Visual Field Tests ; Visual Fields

PURPOSE: To investigate Traquair's "hill of vision" of the normal Korean subjects in the photopic and mesopic background. METHODS: Automated perimetry was performed in 152 normal subjects using Humphrey 24-2 SITA standard (photopic background, n=100) and Octopus G1 full threshold (mesopic background, n=52) program. We calculated and compared the threshold sensitivity and sensitivity deviation of the visual field by the fashion of the superior/inferior hemi-field, temporal/nasal hemi-field, quadrant, and 5 degrees ring. RESULTS: In Humphrey, average mean deviation (MD) and pattern standard deviation (PSD) were -1.22+/-0.86 and 1.43+/-0.33 dB, respectively. In Octopus, average MD and PSD were -3.39+/-1.39 and 1.67+/-0.23 dB, respectively. In both Humphrey and Octopus, the average threshold sensitivity of the inferior hemi-field was slightly higher than that of the superior hemi-field. There was no significant difference between the nasal and temporal hemi-field. The sensitivity was decreased with increasing the eccentricity. In the deviation map of the Humphrey, there were no significant differences in the comparisons of the hemifield, quadrant, and 5 degrees ring. In Octopus, there were no significant differences in the comparisons of the hemifield and quadrant. However, the sensitivity deviation was peaked at the fixation point and decreased with increasing the eccentricity. CONCLUSIONS: These results indicate that the normal Korean subjects may have lower sensitivity than the normal age-matched controls of the automated perimetry, especially in the Octopus perimetry. In addition, this study suggests that the shape of the Traquair's "hill of vision" in the normal Korean subjects might be similar to that of the normal age-matched controls in Humphrey perimetry which was performed in photopic background, but it might be flatter in Octopus perimetry which was performed in mesopic background.
Octopodiformes ; Visual Field Tests ; Visual Fields*

Objective: To report the frequency of neuro-ophthalmologic cases seen over one working week by a senior neuro-ophthalmologist in Singapore and to determine a pattern in the incidence of neuro-ophthalmic diseases. Methods: A retrospective review of 57 consecutive neuro-ophthalmologic cases seen by one senior neuro-ophthalmologist from June 14 to 18, 2010 was done. All patients underwent a complete neuro-ophthalmologic examination. Demographic data and clinical diagnoses were gathered. Results: A total of 57 patients were seen. Thirty-one percent (18) of these patients were new consultations while the remaining 61% (39) were follow-up visits. Fifty-two percent were females (30) with a mean age of 53 years while 47% were males (27) with a mean age of 49 years. Nineteen cases involved disorders of the optic nerve followed by disorders of ocular motility (11), optic chiasm, visual pathways, and/or visual cortex (14). Among the cases involving the optic nerve, 5 were ischemic optic neuropathy. In respect to disorders of ocular motility, ocular myasthenia gravis (n=5) was the most common condition seen. Pituitary adenomas comprised the bulk of the disorders of the optic chiasm (4). The remaining neuro-ophthalmic cases were almost evenly distributed. A very rare case of Froin’s syndrome was also seen. Conclusion Overall, during the five-day neuro-ophthalmologic clinic, majority of cases were ischemic in nature, reminding readers that systemic diseases, such as hypertension, diabetes mellitus, hyperlipidemia, commonly manifest in the eye. Hence, better systemic control of these diseases is necessary.
Optic Nerve Diseases ; Visual Pathways ; Visual Cortex

The aim of this study was to compare optic disc size obtained using the two methods Color polaroid photographs of optic disc of 130 normal subjects and 174 patients with glaucoma were evaluated by means of computeraided morphometry. In the first method, the optic disc size were calculated by applying the modified formula of an ellipse, where area=pi/4xthe horizontal diameterxthe vertical diameter. In the second method, we obtained optic disc size [] using the twelve radii that were measured every 30 degrees. Magnification effects of the eye and camera were corrected in the two methods. The measurements of the optic disc area(2.49mm2), cup area(1.01mm2) and neuroretinal rim area (1.49mm2) by the first method were significantly(P<0.003, Wilcoxon signed -rank test) different from the measurements by the second method(2.48mm2, 1.03mm2, 1.45mm2, respectively) (the average difference; 0.05+/-0.05mm2, 0.05+/-0.05mm2, 0.07+/-0.06mm2,respectively). The mean error for the neuroretinal rim area was 4.2+/-3.3% in the normal group and 7.5+/-8.5% in the glaucoma group(P=0.005). It increased with decreasing neuroretinal rim area and increasing visual field defects. Thus the magnification corrected measurements of the horizontal and vertical diameters and the modified formula of an ellipse can be used for a quick approximate estimation of the optic disc size, but cannot replace more accurate method of optic disc measurements using twelve radii.
Glaucoma ; Humans ; Visual Fields