Japanese encephalitis is a potentially lethal disease of the central nervous system caused by infection with Japanese encephalitis virus (JEV). JEV is the most common cause of encephalitis over a large part of eastern Asia. To establish and characterize in vivo model to study the Japanese encephalitis, the immunohistochemical localization of JEV and the histopathological finding were investigated in the brains of young adult mice infected with JEV by intraperitoneal inoculation. JEV was localized to neurons in discrete regions of the brain. Histopathological finding showed typical pattern of acute viral encephalitis, such as inflammatory cell infiltration in brain parenchyme and perivascular cuffs of mononuclear cells. These results suggest that this in vivo system can be used to study the mechanism of virus entry into the brain, cell specific tropism, and pathophysiology in Japanese encephalitis.
Animals ; Asian Continental Ancestry Group* ; Brain* ; Central Nervous System ; Encephalitis ; Encephalitis Virus, Japanese ; Encephalitis, Japanese* ; Encephalitis, Viral ; Far East ; Humans ; Immunohistochemistry ; Mice* ; Neurons ; Tropism ; Virus Internalization ; Young Adult

Aminoquinolines ; pharmacology ; Anti-HIV Agents ; pharmacology ; Benzimidazoles ; pharmacology ; CCR5 Receptor Antagonists ; CD4 Antigens ; metabolism ; Cyclohexanes ; pharmacology ; HIV-1 ; pathogenicity ; physiology ; Heterocyclic Compounds ; pharmacology ; Heterocyclic Compounds, 1-Ring ; Humans ; Maraviroc ; Piperazines ; pharmacology ; Pyrimidines ; pharmacology ; Receptors, CCR5 ; metabolism ; Receptors, CXCR4 ; antagonists & inhibitors ; metabolism ; T-Lymphocytes ; virology ; Triazoles ; pharmacology ; Viral Tropism