Background: Tophi gout refers to the condition, where consistently high level of uric acid in the body causes the deposition of uric acid or monosodium urate crystals on the joints. Objective: To describe clinical and subclinical features of tophi gout. Subjects and method: A study conducted in 51 patients with tophi gout (according to Bennett-Wood criteria - 1968) in Department of Rheumatology, Bach Mai hospital, from February 2005 to February 2006. This was a cross-sectional prospective study. Results: The average time of tophi appearance lasted 5.3 \xb1 5.7 years. The average number of tophi was 4.5 \xb1 3.9. The most common positions of tophi were tarso - metatarsal - phalangeal joints and elbow joints (43-47%). 100% had gouty arthritis (in which 66.6% > 4 joints), 50-55% involved tarso - metatarsal - phalangeal joints (43.1% had deforming joints). On X-ray, 62.7% cases has injuries, para-articular erosions and overhanging margins (62.5%), joints space narrowing (71.9%), proliferation osseous change (43.8%). Renal stones examined by ultrasound were 41%, renal failure 24.6%. Blood analysis showed hyperuricemia (88.2%), hypertriglyceridemia (54.9%), hyperglycaemia (13.6%). Conclusions: Common features tophi gout were injuries in tarso - metatarsal - phalangeal joints; gouty polyarthritis over 4 joints. X-ray images showed para-articular erosions, joints space narrowing, proliferation osseous changes.
Gout/ pathology ; diagnosis

Background: Acute lymphoblastic leukemia (ALL) is the most common cancer in children. Nowadays there have been achievements in treatment for ALL but side effects and toxicities of chemotherapy are still the major causes of death. Objectives: (1) To find out the rate and grades of side effects and toxicities of chemotherapy on blood forming organ of children with ALL ; (2) to study characteristics of toxicity on blood forming organ in phase of chemotherapy. Subjects and methods: 67 patients with ALL were admitted to Hematology and Oncology Departments of National Hospital of Pediatrics and were treated with chemotherapy of CCG (children cancer group) protocol. Grades of myelosuppression were followed by CCG criteria. Results (l) side effects and toxicities on blood forming organ were common and severe: Leucopenia accounted for 95,5% (grades 3 - 4: 83,6%); neutropenia was 100% (grades 3 - 4: 98,5%); thrombocytopenia was 92,5% (grades 3 - 4: 80,6%); anemia accounted for 98,5% (grades 3 - 4: 58,2%); lymphocytopenia was 89,6% (grades 3 - 4: 64,1%); and marked hypocellularity of marrow was 78,8% in the 14th day (grades 3 - 4: 57,4%) but (2) most of them occurred in the first 2 weeks. Conclusion: Side effects and toxicities of chemotherapy on blood forming organ was common and at quite severe levels but mainly occured in the first two weeks\r\n', u'\r\n', u'\r\n', u'
Precursor Cell Lymphoblastic Leukemia-Lymphoma/ blood

Background: The multiplex polymerase chain reaction can rapidly differentiate taenia spp adults and cysticercose cysts.\r\n', u'Objective: The study aimed to identify taenia spp adults and cysticercose cysts in human by using multiplex PCR\r\n', u'Subjects and methods: The multiplex PCR was applied by using the 4 forward and one reverse primer to amplify the target gene cytochrome c oxydase subunit I (COXI) of the Taenia spp in human. T\r\n', u'Results:4 molecular sizes of PCR products were appeared: 269 bp,720 bp, 827 bp, 984 bp. Seventy six samples including 65 flat worms and 11 cysticercose cysts which collected from the patients who are living in 19 different provinces and cities of Northern part of Viet Nam and treated in the clinic of NIMPE were examined. Of 65 flat worms analyzed 35 samples were T.asiatica (58.46%), 27 were T.saginata (41.54%). All 11 cysticercose cysts were T.solium (100%). \r\n', u'Conclusion: The result also indicated that some time 3 Taenia species were found at the same area. A remarkable difference of infection rate was found between men and women, also adults and children. \r\n', u'\r\n', u'
Taenia spp adults ; cysticercose cysts ; multiplex PCR