1.Perception of disease, well-being and financial burden by patients with chronic hepatitis B: A self-reported assessment.
Ruojun DING ; Gayathry MORVIL ; Boon Bee George GOH ; Thinesh Lee KRISHNAMOORTHY ; Pei Yuh CHIA ; Hiang Keat TAN ; Victoria Sze Min EKSTROM ; Chang Chuen Mark CHEAH ; Jin Yang Terence TAN ; Pek Siang Edmund TEO ; Pik Eu Jason CHANG ; Chee Kiat TAN ; Xiaohui XIN ; Wan Cheng CHOW ; Rajneesh KUMAR
Annals of the Academy of Medicine, Singapore 2022;51(6):378-380
2.The role of PIVKA-II in hepatocellular carcinoma surveillance in an Asian population.
Wai Yoong NG ; Daniel Yan Zheng LIM ; Si Yu TAN ; Jason Pik Eu CHANG ; Thinesh Lee KRISHNAMOORTHY ; Chee Hooi LIM ; Damien Meng Yew TAN ; Victoria Sze Min EKSTROM ; George Boon Bee GOH ; Mark Chang Chuen CHEAH ; Rajneesh KUMAR ; Chin Pin YEO ; Chee Kiat TAN
Annals of the Academy of Medicine, Singapore 2023;52(2):108-110
3.Authors' reply.
Benjy Yi-Min SOH ; Rajneesh KUMAR ; Victoria Sze-Min EKSTROM ; Clement Yi-Hao LIN ; Sobhana D/O THANGARAJU ; Hwee Huang TAN ; Kwai Peng CHAN ; Lina Hui Lin CHOONG ; Diana TEO ; Wan Cheng CHOW
Singapore medical journal 2019;60(6):323-323
Blood Donors
;
Genotype
;
Hepacivirus
;
Humans
;
Interferons
;
Prevalence
4.Prevalence of hepatitis C virus infection and the IL28B genotype polymorphism among blood donors and high-risk populations.
Benjy Yi-Min SOH ; Rajneesh KUMAR ; Victoria Sze-Min EKSTROM ; Clement Yi-Hao LIN ; Sobhana THANGARAJU ; Hwee Huang TAN ; Kwai Peng CHAN ; Lina Hui Lin CHOONG ; Diana TEO ; Wan Cheng CHOW
Singapore medical journal 2019;60(1):34-39
INTRODUCTION:
To study the prevalence of hepatitis C virus (HCV) infection in blood donor (BD), haemodialysis (HD) and intravenous drug user (IVDU) populations in Singapore and assess the IL28B polymorphism if HCV positive.
METHODS:
The BD population were healthy volunteers, the HD population were patients who were on haemodialysis for at least six months of follow-up between January 2009 and December 2014. IVDU population was from inmates at halfway houses who consented.
RESULTS:
Between 2011 and 2014, of 161,658 individuals who underwent screening prior to blood donation, 95 (0.059%) were positive for HCV. Of the 42 sera available, common genotypes (GTs) were GT-3 (47.6%) and GT-1 (31.0%). Of 1,575 HD patients, 2.2% were anti-HCV positive. The HCV GT distribution was HCV GT-1 (32.4%), HCV GT-3 (20.5%) and GT-6 (8.8%). 83 halfway house inmates were screened. Of the 47 IVDUs, 36.2% were anti-HCV positive with predominant GT-3 (%). IL28B polymorphism was noted to be CC predominantly 85.3%.
CONCLUSION
Prevalence of HCV infection has decreased in both the BD and HD populations. However, it remains high in the IVDU population. GT-1 remains the most common in the HD population; however, GT-3 infection is now more common among the BD population in Singapore. IL28B - CC is the predominant variant among the HCV-infected individuals in Singapore.
Acute Kidney Injury
;
blood
;
complications
;
Adult
;
Alleles
;
Blood Donors
;
Female
;
Genotype
;
Hepatitis C
;
epidemiology
;
Humans
;
Interleukins
;
genetics
;
Male
;
Middle Aged
;
Polymorphism, Single Nucleotide
;
Prevalence
;
Renal Dialysis
;
Singapore
;
epidemiology
;
Substance Abuse, Intravenous
;
blood
;
epidemiology
;
Young Adult
Result Analysis
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