1.From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution.
Tran Thi VAN ANH ; Alilou MOSTAFA ; Zhigang RAO ; Simona PACE ; Stefan SCHWAIGER ; Christian KRETZER ; Veronika TEMML ; Carsten GIESEL ; Paul M JORDAN ; Rossella BILANCIA ; Christina WEINIGEL ; Silke RUMMLER ; Birgit WALTENBERGER ; Tran HUNG ; Antonietta ROSSI ; Hermann STUPPNER ; Oliver WERZ ; Andreas KOEBERLE
Acta Pharmaceutica Sinica B 2021;11(6):1629-1647
Chronic inflammation results from excessive pro-inflammatory signaling and the failure to resolve the inflammatory reaction. Lipid mediators orchestrate both the initiation and resolution of inflammation. Switching from pro-inflammatory to pro-resolving lipid mediator biosynthesis is considered as efficient strategy to relieve chronic inflammation, though drug candidates exhibiting such features are unknown. Starting from a library of Vietnamese medical plant extracts, we identified isomers of the biflavanoid 8-methylsocotrin-4'-ol from
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