4.Research progress on cell senescence and cardiac remodeling.
Ruo Chuan LI ; Lu Lu LIU ; Hai Ying RUI ; Hua Xiang YU ; Jin Xin WANG ; Dan ZOU ; Feng XU ; Dan Dan QIN ; Wen Xiao WU ; Yan LIANG ; Kai LIU ; Li XUE ; Yu Guo CHEN
Chinese Journal of Cardiology 2021;49(10):1048-1052
5.The Open Artery Hypothesis.
Korean Circulation Journal 2007;37(6):235-243
There is considerable clinical and experimental evidence of the benefit of late reperfusion of infarct-related arteries, referred to as the open artery hypothesis, in patients with acute myocardial infarction who presented too late to salvage at-risk ischemic myocardium. In addition to myocardial salvage, reperfusion of the infarct-related artery prevents infarct expansion, reduces development of ventricular remodeling, and decreases ventricular arrhythmia. The Occluded Artery Trial recently answered a major question related to the open artery hypothesis in a high-risk, asymptomatic patient with an occluded infarct artery. In this review, clinical and experimental evidence of the benefit of the open artery hypothesis will be discussed.
Arrhythmias, Cardiac
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Arteries*
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Humans
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Myocardial Infarction
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Myocardium
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Reperfusion
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Ventricular Remodeling
8.Erythropoietin promotes myocardial infarction repair in mice by improving the function of Sca-1+ stem cells.
Lin ZUO ; Duan-Duan LI ; Xiu-Xia MA ; Shan-Hui SHI ; Ding-Chao LYU ; Jing SHEN ; Wei-Fang ZHANG ; Er-He GAO ; Ji-Min CAO
Acta Physiologica Sinica 2023;75(1):36-48
Myocardial infarction (MI) is one of the leading causes of death in the world. With the improvement of clinical therapy, the mortality of acute MI has been significantly reduced. However, as for the long-term impact of MI on cardiac remodeling and cardiac function, there is no effective prevention and treatment measures. Erythropoietin (EPO), a glycoprotein cytokine essential to hematopoiesis, has anti-apoptotic and pro-angiogenetic effects. Studies have shown that EPO plays a protective role in cardiomyocytes in cardiovascular diseases, such as cardiac ischemia injury and heart failure. EPO has been demonstrated to protect ischemic myocardium and improve MI repair by promoting the activation of cardiac progenitor cells (CPCs). This study aimed to investigate whether EPO can promote MI repair by enhancing the activity of stem cell antigen 1 positive stem cells (Sca-1+ SCs). Darbepoetin alpha (a long-acting EPO analog, EPOanlg) was injected into the border zone of MI in adult mice. Infarct size, cardiac remodeling and performance, cardiomyocyte apoptosis and microvessel density were measured. Lin- Sca-1+ SCs were isolated from neonatal and adult mouse hearts by magnetic sorting technology, and were used to identify the colony forming ability and the effect of EPO, respectively. The results showed that, compared to MI alone, EPOanlg reduced the infarct percentage, cardiomyocyte apoptosis ratio and left ventricular (LV) chamber dilatation, improved cardiac performance, and increased the numbers of coronary microvessels in vivo. In vitro, EPO increased the proliferation, migration and clone formation of Lin- Sca-1+ SCs likely via the EPO receptor and downstream STAT-5/p38 MAPK signaling pathways. These results suggest that EPO participates in the repair process of MI by activating Sca-1+ SCs.
Animals
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Mice
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Ventricular Remodeling
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Erythropoietin
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Myocardial Infarction
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Heart
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Stem Cells
9.Mitral Regurgitation due to Recurrent Septal Rupture after Repair of a Postinfarction Posterior Ventricular Septal Defect: A Case Report.
The Korean Journal of Critical Care Medicine 2009;24(1):39-41
Postinfarction ventricular septal rupture (VSR) is a serious complication following an acute myocardial infarction. We performed repair of a postinfarction posterior VSR; however, the patient developed mitral regurgitation (MR) 2 months later. Geometrical changes caused by ventricular remodeling and recurrent shuntare thought to be the cause of delayed MR.
Humans
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Mitral Valve Insufficiency
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Myocardial Infarction
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Rupture
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Ventricular Remodeling
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Ventricular Septal Rupture