At the Cardiovasculary Department of Thanh Nhan Hispital – Ha Noi from January to December 31, 2002. 33 ventricle extrasystolic (VES) patients were investigated. VES is a common condition, accounts for 17.6%, classified in the 3rd rank of heart arhythmic conditions, accounts for 2.9% of total number of cardiovascular diseases. The most common is sparse left ventricle extrasystol losing compensation of monoform and monofocus. The most common causes of the disease is high blood pressure – 30.3%, heart valve – 21.2%. The morbidity is higher in female than in male, increasing with the age. The most common complication is ventricle tachycardiac. Ventricle fibrillation is less common but it’s fatally dangerous
Ventricular Premature Complexes ; Cardiovascular Diseases ; heart

The effect of oral mexiletin was evaluated by a 10-day double-blind cross-over protocol on 10 subjects with chronic stable high-frequency ventricular premature beats referred to our cardiology clinic from February through July, 1982. Total daily doses were either 450mg or 600mg in three divided portions depending on body weight. The frequency of the premature ventricular beats was measured by 3 separate 24-hour ambulatory EKG recordings by dual-channel Holter monitor on each patient. Mexiletine was judged to be effective in suppressing the ventricular arrhythmias when the 24-hour PVC-counts during the study-drug period showed a decrease by 80% and the hourly average PVC-counts by 70% compared with those of the equivalent intervals of both the baseline and the placebo periods. Mexiletine was effective in 5 of the 10 subjects. Mild tremor and anorexia were noted in 2 patients, but they were able to comply with the study protocol in spite of these minor side effects. Blood level measurements were not done in this study for lack of such facility, the utilization of which would undoubtedly enhance the therapeutic effectiveness of the antiarrhythmic agent in the individualization of treatment.
Anorexia ; Arrhythmias, Cardiac ; Body Weight ; Cardiac Complexes, Premature* ; Cardiology ; Electrocardiography ; Humans ; Mexiletine* ; Tremor ; Ventricular Premature Complexes

BACKGROUND AND OBJECTIVES: Frequent ventricular premature complex (VPC) is one of the most common arrhythmia syndromes. Symptoms observed frequently with this arrhythmia syndrome remain limited. We sought to identify predictors of VPC-related symptoms by analyzing demographic information, VPC burden, and VPC surface electrocardiogram characteristics. SUBJECTS AND METHODS: We prospectively enrolled 109 patients with idiopathic outflow tract VPCs (63 males, 49+/-16 years old). They were divided into Group A (n=30, without VPC-related symptoms of palpitations or "dropped beats") and Group B (n=79, with VPC-related symptoms). Measured parameters were sinus and VPC QRS width, coupling interval (CI) between the previous sinus beat and VPC, CI ratio (%, CI/sinus cycle length), post-VPC CI and CI ratio, and VPC amplitude. RESULTS: Both groups had similar age (p=0.22), daily VPC burden (p=0.15), and VPC site of origin (p=0.36). The VPC CI ratio was higher in Group B (60+/-15%) than in Group A (49+/-22%) (p=0.01). CONCLUSION: VPC-related symptoms are associated with a higher VPC CI ratio (>50%). The physiologic basis for these results deserves further study.
Arrhythmias, Cardiac ; Electrocardiography ; Humans ; Male ; Prospective Studies ; Ventricular Premature Complexes

Centrifuge high +Gz training has been reported to provoke cardiac arrhythmias in ostensibly healthy individuals, and ECG monitoring of aircrew undergoing such training is recommended for their safety. However, there are few reports about ECG responses during actual high +Gz flight. Therefore, we start this study to determine the ECG responses during actual high +Gzz flight of F-5. In our study, twenty-four pilots, ages 25-37 and one Flight Surgeon were monitored by Holter ECG monitor for four hours, which included periods before, during, and after either a high +Gz or low +Gz flight in a F-5, Actual flight times ranged from 28-78 minutes. Sixteen(16) pilots were monitored in both high +Gz (>5Gz) and low +Gz (<3Gz) flight, the flight surgeon and seven(7) pilots were monitored only in high +Gz flight, one pilot was monitored only in low +Gz flight. Heart rate(HR) and cardiac rhythm were evaluated during a total of 41 flights. During the high +Gz flight, there was one episode of visual black out and dyspnea, three episodes of gray out, and one episode of fatigue. During the low +Gz flight, there were two episodes of coughing. The frequency of occurrence of Ventricular Ectopic Beats (VEs) (Premature Ventricular Contractions (PVCs), especially in-flight VEs(PVCs), was significantly higher in pilots who hart symptoms during the flight as compared to pilots who had no symptoms in one pilot, we recorded 16 VEs (PVCs) over the four houris wlth 10 VEs occurring during the flight. Another pilot experienced 254 Supraventricular ectopic beats (SVEs)(Premature Atrial Contractions (PVCs) or Premature Junctional Contractions (PVCs)) with a total of 87 SVEs recorded during the flight. In high +Gz flight, there were, overall, twelve (12) cases of VEs and fifteen (15) cases of SVEs. In low +Gz flight, there were four (4) cases of VEs anti ten (10) cases of SVEs. In addition, We correlated the HR 30 minutes before flight (range of 52-117 bpm) with maximum in-flight HR (range of 92-178 bpm). We found that the maximum HR during the flight was lower with increased pilot's experience (i.e., age and total flight time). There was no significant difference noted in HR and cardiac arrhythmias when comparing high +Gz and low +Gz flight. During the high +Gz flight, stress may cause symptoms with minor cardiac arrhythmias. Further studies shou1d be done to better correlate the exact relationship and timing between onset of +Gz forces, arrhythmias, and occurrence of adverse clinical symptoms.
Arrhythmias, Cardiac ; Cough ; Dyspnea ; Electrocardiography* ; Fatigue ; Heart ; Ventricular Premature Complexes

BACKGROUND AND OBJECTIVES: Heart rate variability (HRV) illustrates the autonomic integration of the heart. Depressed HRV has been proven to be associated with an increased risk of cardiac death, whereas heart rate turbulence (HRT) is believed to reflect baroreflex sensitivity and it was recently introduced as another noninvasive tool for risk stratification. The aim of this study was to determine the relationship between the HRT and HRV parameters in Korean adults with a structurally normal heart. SUBJECTS AND METHODS: We studied 61 adults (males: 31) who showed ventricular premature complexes on 24 hour Holter recording and who were found to have normal hearts on full noninvasive investigation. We calculated the mean heart rate (RR interval), the number of VPBs, the time- and frequency-domain HRV parameters and two HRT parameters: turbulence onset (To) and turbulence slope (Ts). RESULTS: Ts showed a strong correlation with the HRV parameters (LF/HF ratio: r=0.35, p=0.006; VLF: r=0.32, p=0.013; LF: r=0.27, p=0.035; SDNN: r=0.28, p=0.029; SDANN: r=0.32, p=0.012), but To showed no significant correlation with the HRV parameters. CONCLUSION: The HRT parameters, and especially Ts, correlate strongly with the HRV parameters; therefore, Ts should be considered as a parameter that reflects the overall cardiac autonomic tone.
Adult* ; Baroreflex ; Death ; Heart Rate* ; Heart* ; Humans ; Ventricular Premature Complexes

Acupuncture Therapy ; Female ; Humans ; Middle Aged ; Ventricular Premature Complexes ; therapy

On the basis of Poincare scatter plot and first order difference scatter plot, a novel heart rate variability (HRV) analysis method based on scatter plots of RR intervals and first order difference of RR intervals (namely, RdR) was proposed. The abscissa of the RdR scatter plot, the x-axis, is RR intervals and the ordinate, y-axis, is the difference between successive RR intervals. The RdR scatter plot includes the information of RR intervals and the difference between successive RR intervals, which captures more HRV information. By RdR scatter plot analysis of some records of MIT-BIH arrhythmias database, we found that the scatter plot of uncoupled premature ventricular contraction (PVC), coupled ventricular bigeminy and ventricular trigeminy PVC had specific graphic characteristics. The RdR scatter plot method has higher detecting performance than the Poincare scatter plot method, and simpler and more intuitive than the first order difference method.
Arrhythmias, Cardiac ; Databases, Factual ; Heart Rate ; Humans ; Ventricular Premature Complexes

Background and Objective: Premature ventricular complex (PVC) burden exhibits one of three circadian types, classified as fast-type, slow-type, and independent-type PVC. It is unknown whether PVC circadian types have different heart rate variability (HRV) parameter values. Therefore, this study aimed to evaluate differences in HRV circadian rhythm among fast-, slow-, and independent-type PVC. Methods: This cross-sectional observational study consecutively recruited 65 idiopathic PVC subjects (23 fast-, 20 slow-, and 22 independent-type) as well as five control subjects. Each subject underwent a 24-hour Holter to examine PVC burden and HRV. HRV analysis included components that primarily reflect global, parasympathetic, and sympathetic activities. Repeated measures analysis of variance was used to compare differences in HRV circadian rhythm by PVC type. Results. The average PVC burden was 15.7%, 8.4%, and 13.6% in fast-, slow-, and independent-type idiopathic PVC subjects, respectively. Global, parasympathetic nervous system, and sympathetic nervous system HRV parameters were significantly lower in independenttype PVC versus fast- and slow-type PVC throughout the day and night. Furthermore, we unexpectedly found that tendency towards sympathetic activity dominance during nighttime was only in independent-type PVC. Conclusion The HRV parameters are reduced in patients with independent-type PVC compared to fast- and slowtype PVC. Future research is warranted to determine possible differences in the prognosis between the three PVC types.
Ventricular Premature Complexes ; Circadian Rhythm ; Autonomic Nervous System

Cardiac arrhythmias are a common problem in the neurological intensive care unit and represent a major cause of ischemic stroke. Significant arrhythmias are most likely to occur in elderly patients. In this review, we focus on three arrhythmias: premature beats, atrial fibrillation, and QT prolongation. The goal of this review is to provide a current concept of diagnosis and acute management of arrhythmias in the neurological intensive care unit.
Aged ; Arrhythmias, Cardiac ; Atrial Fibrillation ; Atrial Premature Complexes ; Cardiac Complexes, Premature ; Critical Care ; Diagnosis ; Humans ; Intensive Care Units ; Stroke ; Ventricular Premature Complexes

In this paper, the multifractal detrended fluctuation analysis method was used to study the multifractal characteristics of atrial premature beat (APB) signals, of premature ventricular contraction (PVC) signals and of normal ECG signals. By analyses of Hurst index, Renyi index and multifractal spectrum, three kinds of signals were noted to have different degrees of long-range correlation and multifractal characteristics. Normal ECG signals had the strongest fractality, the PVC beats had stronger fractality and the APB beats had the weakest fractality. When the fluctuations function order was positive, the three kinds of signals showed distinct long-range correlation properties. These findings are of good reference to diagnosing and distinguishing between PVC and APB signals in clinical medicine.
Atrial Premature Complexes ; diagnosis ; physiopathology ; Diagnosis, Differential ; Electrocardiography ; methods ; Humans ; Signal Processing, Computer-Assisted ; Ventricular Premature Complexes ; diagnosis ; physiopathology