2.Efficacy evaluation of novel oral anticoagulants in patients with cirrhosis accompanied with portal vein thrombosis: a meta-analysis.
Xiao Tong XU ; Yu Wei LIU ; Jing Lan JIN
Chinese Journal of Hepatology 2023;31(6):614-620
Objective: To analyze the safety and efficacy of using novel oral anticoagulants (rivaroxaban and others) in patients with cirrhosis accompanied with portal vein thrombosis (PVT). Methods: Clinical research literature published from the establishment of the database to June 20, 2021, was retrieved from PubMed, Web of Science, CNKI, Wanfang, and Weipu databases by combining subject terms and free words. RevMan software was used for the random group meta-analysis model. Results: In terms of PVT recanalization, the novel oral anticoagulants (such as low molecular weight heparin and others) had a higher recanalization rate than traditional anticoagulants (OR = 13.75, 95%CI 3.58-52.9, P = 0.000 1). In terms of bleeding, the novel oral anticoagulants did not increase the risk of bleeding compared with traditional anticoagulants (OR = 2.42, 95%CI 0.62-9.41, P = 0.20). Conclusion: The novel oral anticoagulant drugs are superior to traditional anticoagulants in terms of the occurrence of PVT recanalization; however, there is no statistically significant difference in terms of the occurrence of bleeding between the two groups.
Humans
;
Portal Vein/pathology*
;
Treatment Outcome
;
Venous Thrombosis/complications*
;
Liver Cirrhosis/pathology*
;
Anticoagulants/therapeutic use*
;
Hemorrhage
3.Multiple myeloma with pulmonary embolism: a case report.
Ke-jing YING ; Yong ZHOU ; Hao JIANG ; En-guo CHEN ; Pan ZHOU
Chinese Medical Journal 2006;119(17):1481-1484
4.Deficiencies in proteins C and S in a patient with idiopathic portal hypertension accompanied by portal vein thrombosis.
Sena HWANG ; Do Young KIM ; Minju KIM ; Young Eun CHON ; Hyun Jung LEE ; Young Nyun PARK ; Jun Yong PARK ; Sang Hoon AHN ; Kwang Hyub HAN ; Chae Yoon CHON
The Korean Journal of Hepatology 2010;16(2):176-181
Portal vein thrombosis (PVT) is an uncommon cause of presinusoidal portal hypertension. Among various hepatoportal disorders, noncirrhotic portal hypertension conditions such as idiopathic portal hypertension (IPH) are considered to have a close relation with PVT. PVT is known to have several predisposing conditions, including infection, malignancies, and coagulation disorders. There is growing interest and recognition that deficiencies in proteins C and S are associated with a hypercoagulable state. These deficiencies are regarded as key factors of systemic hypercoagulability and recurrent venous thromboembolism. We report the case of a 19-year-old male diagnosed as IPH with PVT and combined deficiencies in proteins C and S.
Humans
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Hypertension, Portal/complications/*diagnosis/pathology
;
Male
;
*Portal Vein
;
Protein C Deficiency/*complications
;
Protein S Deficiency/*complications
;
Tomography, X-Ray Computed
;
Venous Thrombosis/complications/*diagnosis/pathology
;
Young Adult
5.Hybrid operation for acute left leg deep venous thrombosis secondary to left iliac vein compression syndrome: analysis of 36 cases.
Zhong-Xin ZHOU ; Fang-Yong FU ; Zhi-Qi LIN ; Chun-Qiu PAN
Journal of Southern Medical University 2015;35(1):131-134
OBJECTIVETo evaluate the surgical techniques for acute left deep venous thrombosis (LDVT) secondary to left iliac vein compression syndrome (IVCS).
METHODSThirty-six patients with acute LDVT secondary to IVCS received inferior vena cava filter placement, and in 2 of the cases, stent implantation was canceled for acute episode of obsolete DVT. The remaining 34 patients underwent left femoral venotomy for iliofemoral thrombectomy with Fogarty catheter and distal femoral vein thrombus removal by sequential compression of the legs, followed by implantation of stent-graft (2 cases) or bare-metal stents (32 cases) in the left common iliac veins. With routine anticoagulation and thrombolytic treatments, the patients were regularly examined for postoperative blood flow in the affected limb.
RESULTSIn 2 of the cases undergoing bare-metal stent implantation, the residue thrombi were squeezed into the stent by balloon, which was managed subsequently with local thrombolysis. One patient with bare-metal stent implantation received a secondary stenting for posterior stent displacement. Three patients had self-limited bleeding due to decreased serum FBG. Significant improvements were achieved at 3, 6, 30 and 180 days postoperatively in the circumferences of the affected limb (P<0.05) and in the levels of D-dimer (P=0.011), and FBG level showed no significant variations (F=1.163, P=0.345). The total rate of excellent outcomes was 83.3% (26/34) with a total effective rate of 91.2% (31/34) in these cases.
CONCLUSIONSThrombectomy to revascularize the inflow tract and stent implantation to enlarge stenosed iliac veins are key issues in treatment of acute LDVT secondary to IVCS.
Femoral Vein ; surgery ; Humans ; Leg ; pathology ; May-Thurner Syndrome ; complications ; surgery ; Stents ; Thrombectomy ; Vascular Grafting ; Venous Thrombosis ; etiology ; surgery
6.Exercise versus immobilization in the treatment of acute deep vein thrombosis during different clot-organized stage: an animal experiment.
Haoshan QI ; Fuxian ZHANG ; Yong LIU ; Fengcai YAN ; Yanyu LONG ; Gangzhu LIANG ; Zhimin GAO ; Dalin LI ; Kun ZHANG
Chinese Journal of Surgery 2014;52(7):529-532
OBJECTIVETo evaluate the corresponding influence on pulmonary embolism incidence between immobilization and exercise in different stage of thrombus after acute deep vein thrombosis in rabbits.
METHODSForty-eight New Zealand rabbits were randomly divided into three groups depending on the different organized stage of thrombus: the early, medium and later stage group.Each group was subdivided into two sub groups: the immobile and mobile subgroup. Rabbit modeling of deep vein thrombosis was made by ligating the right femoral vein. Among the early-stage group, rabbits of the immobile subgroup were fixed for 3 days, while that of the mobile subgroup were free to move for 3 days, then each was euthanized to extract the lungs for pathological examination. Among the medium-stage group, each of the immobile subgroup were fixed for 7 days, while the mobile subgroup ones were fixed for 3 days, then released free-moving for 4 days following the pathological extraction. Among the later-stage group, animals in the immobile subgroup were fixed for 14 days comparing the mobile subgroup fixed for 7 days and next free-moving for 7 days, then each was euthanized.
RESULTSAmong the early-stage group, pulmonary embolism incidence (PEI) of the immobile and mobile subgroup was 4/8 vs.3/8, the pulmonary lobe embolism incidence (PLEI) was 17.5% (7/40) vs. 15.0% (6/40). Among the medium-stage group, PEI of the immobile and mobile subgroup was 3/8 vs. 2/8, PLEI was 37.5% (7/40) vs. 25.0% (10/40). Among the later-stage group, PEI of the immobile and mobile subgroup was 3/8 vs. 3/8, PLEI was 12.5% (5/40) vs. 15.0% (6/40). There was no statistical difference between immobilization subgroup and mobilization subgroup among different stage group.
CONCLUSIONOn the premise of given anticoagulation treatment, early ambulation do not significantly increase pulmonary embolism incidence after acute deep vein thrombosis of lower extremity in rabbits.
Animals ; Disease Models, Animal ; Immobilization ; Lung ; pathology ; Motor Activity ; Pulmonary Embolism ; etiology ; Rabbits ; Time Factors ; Venous Thrombosis ; complications
7.Mesocaval Shunt Creation for Jejunal Variceal Bleeding with Chronic Portal Vein Thrombosis
Ja Kyung YOON ; Man Deuk KIM ; Do Yun LEE ; Seok Joo HAN
Yonsei Medical Journal 2018;59(1):162-166
The creation of transjugular intrahepatic portosystemic shunt (TIPS) is a widely performed technique to relieve portal hypertension, and to manage recurrent variceal bleeding and refractory ascites in patients where medical and/or endoscopic treatments have failed. However, portosystemic shunt creation can be challenging in the presence of chronic portal vein occlusion. In this case report, we describe a minimally invasive endovascular mesocaval shunt creation with transsplenic approach for the management of recurrent variceal bleeding in a portal hypertension patient with intra- and extrahepatic portal vein occlusion.
Adolescent
;
Chronic Disease
;
Esophageal and Gastric Varices/complications
;
Esophageal and Gastric Varices/diagnostic imaging
;
Esophageal and Gastric Varices/therapy
;
Female
;
Gastrointestinal Hemorrhage/complications
;
Gastrointestinal Hemorrhage/diagnostic imaging
;
Gastrointestinal Hemorrhage/therapy
;
Humans
;
Jejunum/pathology
;
Portacaval Shunt, Surgical
;
Portal Vein/diagnostic imaging
;
Portal Vein/pathology
;
Portal Vein/surgery
;
Tomography, X-Ray Computed
;
Treatment Outcome
;
Venous Thrombosis/complications
;
Venous Thrombosis/diagnostic imaging
;
Venous Thrombosis/therapy
8.A Case of Chronic Pancreatitis Associated with Liver Infarction and Acrodermatitis Enteropathica.
Byung Chul KIM ; Kwang Ro JOO ; Hyo Sup LEE ; Yoong Ki JEONG ; Ho Seok SUH ; Do Ha KIM ; Neung Hwa PARK ; Jae Hoo PARK
The Korean Journal of Internal Medicine 2002;17(4):263-265
Liver infarction and acrodermatitis enteropathica are rare complications of chronic pancreatitis. This report shows the case of a 56-year-old man who developed liver infarction due to portal vein thrombosis from chronic pancreatitis and acrodermatitis enteropathica during the course of his treatment. The rare combination of these complications in a patient with chronic pancreatitis has never previously been reported in the literature.
Acrodermatitis/*etiology/pathology/therapy
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Chronic Disease
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Human
;
Infarction/*etiology
;
Liver/*blood supply
;
Male
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Middle Aged
;
Pancreatitis/*complications
;
Portal Vein
;
Venous Thrombosis/complications/etiology
;
Zinc/administration & dosage/deficiency
9.Treatment of hepatocellular carcinoma complicated with main portal vein tumor thrombus with transcatheter chemoembolization and portal vein stenting.
Xue-bin ZHANG ; Jian-hua WANG ; Zhi-ping YAN ; Sheng QIAN ; Gao-quan GONG ; Rong LIU ; Qing-xin LIU ; Jian-jun LUO ; Yi CHEN
Chinese Journal of Hepatology 2008;16(7):536-537
Carcinoma, Hepatocellular
;
complications
;
drug therapy
;
pathology
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Chemoembolization, Therapeutic
;
methods
;
Female
;
Humans
;
Liver Neoplasms
;
complications
;
drug therapy
;
pathology
;
Male
;
Neoplastic Cells, Circulating
;
Portal Vein
;
pathology
;
Stents
;
Venous Thrombosis
;
complications
;
pathology
10.Modified CLIP Score as a New Prognostic Index for Patients with Hepatocellular Carcinoma.
Seung Ho HAN ; Sang Young HAN ; Byoung Soung GO ; Min Ji KIM ; Jung Hyun LEE ; Young Hun KOO ; Seung Hoon RYU ; Jeong Hwan CHO ; Jin Seok JANG ; Jong Hoon LEE ; Myung Hwan ROH ; Seok Ryeol CHOI ; Joung Chel CHOI ; Sung Wook LEE
The Korean Journal of Hepatology 2006;12(2):209-220
BACKGROUNDS/AIMS: The prognosis of cirrhotic patients with hepatocellular carcinoma (HCC) depends on both residual liver function and tumor characteristics. The aims of this study was to construct a new prognostic index for HCC patients: the modified CLIP score, and to compare its discriminatory ability and predictive power with those of the CLIP score that is currently the most commonly used integrated staging score in patients of HCC. METHODS: A retrospective analysis of 237 cases of HCC diagnosed at Dong-A university hospital was performed. Prognostic analysis was performed for single variables by estimating survival distributions with the Kaplan-Meier's method, and statistically compared by the log-rank test. RESULTS: Patients had a mean age of 57.5 years and were predominantly males (79.7%). The overall median survival period was 25.7 months. It was correlated to ascites, portal vein thrombosis, AFP, tumor size, and Child-Pugh classification. The median survival period was 41.0, 25.2, 13.8, 13.4, and 6.5 months for CLIP scores 0, 1, 2, 3, and 4 to 6, respectively (P<0.001), and 42.1, 34.0, 25.7, 14.0, and 6.8 months for modified CLIP scores 0, 1, 2, 3, and 4 to 6, respectively (P<0.001). The Kaplan-Meier's curve showed that the modified CLIP score had additional explanatory power above that of the CLIP score. CONCLUSIONS: The modified CLIP score, compared with the CLIP score, particularly in the score 2- to 3- patient groups of HCC, had greater discriminant ability and survival predictive power, but was not able to discriminate 4- to 6- patient group.
alpha-Fetoproteins/analysis
;
Venous Thrombosis/complications
;
Survival Analysis
;
Prognosis
;
Neoplasm Staging
;
Middle Aged
;
Male
;
Liver Neoplasms/complications/mortality/*pathology
;
Liver Cirrhosis/complications
;
Humans
;
Female
;
Carcinoma, Hepatocellular/complications/mortality/*pathology
;
Aged, 80 and over
;
Aged
;
Adult