1.Spontaneous Dissolution of Isolated Superior Mesenteric Vein Thrombosis in Acute Pancreatitis.
Byung Soo NA ; Byung Min JOHN ; Ki Bum KIM ; Je Soo LEE ; Hyun Woo JO ; Chang Hyeon SEOCK ; Dong Hui KIM ; Ki Sung LEE
The Korean Journal of Gastroenterology 2011;57(1):38-41
Acute pancreatitis can result in many vascular complications in both artery and vein. Venous complication usually occurs as a form of splenic or portal vein thrombosis, and also can simultaneously occur in superior mesenteric vein as well. Rarely, isolated superior mesenteric vein thrombosis occurs as a venous complication. Although it is uncommon, mesenteric vein thrombosis is an important clinical entity because of the possibility of mesenteric ischemia and infarction of small bowel. The treatments of mesenteric venous thrombosis include anticoagulation therapy, transcatheter therapy and surgical intervention. We report a case of 45-year-old man who had acute pancreatitis with isolated superior mesenteric vein thrombosis, which was spontaneously dissolved with the resolution of underlying inflammation without anticoagulation or surgical intervention.
Acute Disease
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Humans
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Male
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*Mesenteric Veins
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Middle Aged
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Pancreatitis/complications/*diagnosis
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Tomography, X-Ray Computed
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Venous Thrombosis/*diagnosis/etiology/radiography
2.Clinics in diagnostic imaging (146). Polycythaemia vera (PV).
Singapore medical journal 2013;54(5):289-quiz 292
A 42-year-old Chinese man presented with left-sided chest pain and splenomegaly. Full blood count revealed erythrocytosis, while plain radiograph and computed tomography of the abdomen and pelvis revealed hepatosplenomegaly with splenic infarction. Further workup confirmed the diagnosis of polycythaemia vera. Clinical and imaging features of polycythaemia vera, as well as the potential pitfalls in image interpretation, are discussed in this article.
Adult
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Brain
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pathology
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Cerebral Infarction
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complications
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diagnosis
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Diagnostic Imaging
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methods
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Humans
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Liver
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pathology
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Male
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Middle Aged
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Polycythemia Vera
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diagnosis
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diagnostic imaging
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Radiography, Abdominal
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methods
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Seizures
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diagnosis
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Splenomegaly
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diagnosis
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Tomography, X-Ray Computed
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methods
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Venous Thrombosis
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diagnosis
3.A Case of Renal Vein Thrombosis in a Patient with Ulcerative Colitis.
Dong Jin YANG ; Young Sook PARK ; Yeon Hwa YU ; Yun Ju JO ; Seong Hwan KIM ; Yoon Young JUNG ; Young Hwan HWANG ; Dae Won JUN
The Korean Journal of Gastroenterology 2009;54(4):248-251
Venous thrombosis and thromboembolism appear to occur more often in patient with inflammatory bowel disease (IBD). The cause of thrombotic complications in IBD is generally considered to be associated with hypercoagulable conditions. Its prevalence rate ranges from 1% to 8% in clinical studies and rises to 39% in autopsy, but the renal vein thrombosis is very rare complication in ulcerative colitis patient. A 24-year-old man presented with intermittent abdominal pain and hematochezia for 6 months and recently developed pitting edema for few weeks. He was diagnosed as severe ulcerative colitis involving whole colon combined with thrombosis in both renal veins by colonoscopy and computed tomography scan of abdomen. We used steroid for the treatment of ulcerative colitis and both intravenous lower molecular weight heparin and warfarin for renal vein thrombosis. His symptoms were improved after treatment and maintained with mesalazine and warfarin. Follow-up abdominal CT scan showed complete resolution of both renal vein thrombosis. Currently he has been followed up for 2 years with oral mesalazine.
Anticoagulants/therapeutic use
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Colitis, Ulcerative/complications/*diagnosis/pathology
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Colonoscopy
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Heparin/therapeutic use
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Humans
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Male
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Protein S/metabolism
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*Renal Veins
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Tomography, X-Ray Computed
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Venous Thrombosis/complications/*diagnosis/radiography
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Warfarin/therapeutic use
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Young Adult
4.Portal-Splenic-Mesenteric Venous Thrombosis in a Patients with Protein S Deficiency due to Novel PROS1 Gene Mutation.
Eui Tae HWANG ; Won Sik KANG ; Jin Woo PARK ; Ji Hyun LEE ; Hyun Jeong HAN ; Sang Yong SHIN ; Hee Jin KIM ; Ja Sung CHOI
The Korean Journal of Gastroenterology 2014;64(2):110-114
Protein S (PS), a vitamin K-dependent glycoprotein, performs an important role in the anticoagulation cascade as a cofactor of protein C. Because of the presence of a pseudogene and two different forms of PS in the plasma, protein S deficiency (PSD) is one of the most difficult thrombophilias to study and a rare blood disorder associated with an increased risk of thrombosis. We describe a unusual case of previously healthy 37-year-old man diagnosed with portal-splenic-mesenteric vein thrombosis secondary to PSD. The patient was admitted to the hospital due to continuous nonspecific abdominal pain and nausea. Abdominal computed tomography revealed acute venous thrombosis from inferior mesenteric vein to left portal vein via splenic vein, and laboratory test revealed decreased PS antigen level and PS functional activity. Conventional polymerase chain reaction and direct DNA sequencing analysis of the PROS1 gene demonstrated duplication of the 166th base in exon 2 resulting in frame-shift mutation (p.Arg56Lysfs*10) which is the first description of the new PROS1 gene mutation to our knowledge. Results from other studies suggest that the inherited PSD due to a PROS1 gene mutation may cause venous thrombosis in a healthy young man without any known predisposing factor.
Adult
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Anticoagulants/therapeutic use
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Base Sequence
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Blood Proteins/*genetics
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Codon, Terminator
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Exons
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Humans
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Male
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Mesenteric Veins/radiography
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Polymorphism, Restriction Fragment Length
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Portal Vein/radiography
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Protein S Deficiency/complications/*diagnosis
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Sequence Analysis, DNA
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Splenic Vein/radiography
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Tomography, X-Ray Computed
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Venous Thrombosis/*diagnosis/drug therapy/etiology