No abstract available.
Vasculitis, Leukocytoclastic, Cutaneous*

Glycine/analogs & derivatives* ; Humans ; Vasculitis, Leukocytoclastic, Cutaneous

No abstract available.
Hypersensitivity ; Influenza, Human ; Vaccination ; Vasculitis ; Vasculitis, Leukocytoclastic, Cutaneous

A 24-year old woman presented with hemorrhagic vesicles on her legs. She had taken sibutramine (Reductil(R), Abbott Labs., Seoul, South Korea) for 3 months and developed skin lesions the week before. A skin biopsy showed leukocytoclastic vasculitis with conspicuous eosinophilic infiltration of the tissue. These lesions showed improvement after discontinuation of sibutramine. However, 3 months later the skin lesions recurred on other sites on the lower extremities when the patient was rechallenged with the same drug for 2 weeks. Herein, we report the first case of necrotizing vasculitis induced by sibutramine.
Biopsy ; Cyclobutanes ; Eosinophils ; Female ; Humans ; Leg ; Lower Extremity ; Skin ; Vasculitis ; Vasculitis, Leukocytoclastic, Cutaneous

Acute hemorrhagic edema of infancy is a cutaneous leukocytoclastic vasculitis, which is clinically characterized by acute development of peripheral edema and targetoid purpuric lesions on the face and extremities. The clinical picture has a violent onset with a short benign course, followed by spontaneous complete recovery. We describe a 7-month-old girl with acute hemorrhagic edema, in whom the disease occurred with otitis media.
Edema ; Extremities ; Humans ; Infant ; Otitis ; Otitis Media ; Vasculitis ; Vasculitis, Leukocytoclastic, Cutaneous

The most clearly delineated condition with prominent cutaneous leukocytoclastic vasculitis which presents to a pediatrician is Henoch-Sch nlein purpura. There is general agreement that in Henoch-Sch nlein syndrome the skin manifestations have a very benign long-term course and that corticosteroids are of little value. Dapsone appears to be of special value in diseases characterized by an accumulation of polymorphonuclear neutrophils notably leukocytoclastic vasculitis. In the pediatric literature, however, no information is available on the use of this sulfone in Henoch-Sch nlein purpura. We report a case of Henoch-Sch nlein purpura in a 14-year-old female patient who presented with chronic recurrent skin manifestation and responded to dapsone for two years.
Adolescent ; Adrenal Cortex Hormones ; Dapsone* ; Female ; Humans ; Neutrophils ; Purpura* ; Skin Manifestations ; Vasculitis ; Vasculitis, Leukocytoclastic, Cutaneous

Acute hemorrhagic edema of childhood is an uncommon form of cutaneous leukocytoclastic vasculitis that occurs in children younger than 3 years. This is characterized by tender edema and rosette-shaped purpuric patches that generally resolve without intervention. We describe a 26-month-old boy with acute hemorrhagic edema of childhood, in whom the disease appeared after an acute respiratory illness. Skin lesions presented with acral edema, and rosette-shaped purpuric plaques on the face and limbs. Some authors consider the disease as a purely cutaneous form of Henoch-Schoenlein purpura, but it is more likely that acute hemorrhagic edema of childhood could be regarded as a distinct entity within leukocytoclastic vasculitis.
Child ; Child, Preschool ; Edema* ; Extremities ; Humans ; Male ; Purpura, Schoenlein-Henoch ; Skin ; Vasculitis ; Vasculitis, Leukocytoclastic, Cutaneous

Herein, we report a case of an 8-year-old girl with dapsone hypersensitivity syndrome (DHS) that occurred during the treatment of erythema elevatum diutinum. She had fever, gross hematuria, and malaise for three weeks after initiation of dapsone therapy. Five days after stopping dapsone treatment, she returned to the emergency clinic because of high fever, emesis, diarrhea, upper respiratory symptoms, and worsening of exanthematous eruptions. A diagnosis of DHS was made, and it improved with oral prednisone. We recommend that pediatric patients who are treated with dapsone need to be observed carefully for the development of DHS.
Child ; Dapsone ; Diarrhea ; Emergencies ; Erythema ; Fever ; Hematuria ; Humans ; Hypersensitivity ; Prednisone ; Vasculitis, Leukocytoclastic, Cutaneous ; Vomiting

Acute hemorrhagic edema of infancy (AHEI) is an uncommon form of cutaneous leukocytoclastic vasculitis that occurs in infants and children younger than 2 years. AHEI is characterized clinically by marked peripheral edema and fever as well as large palpable purpuric and ecchymotic skin lesions in a target-like pattern, mainly on the face, ears and extremities, similar to the skin findings of Henoch-Schonlein purpura (HSP). The skin lesions heal spontaneously within one to three weeks and internal organs are rarely affected. We report a case of AHEI occurring in a 23-month-old boy who was initially misdiagnosed as HSP, and was later diagnosed according to his clinical symptoms and histochemical characteristics.
Child ; Ear ; Edema* ; Extremities ; Fever ; Humans ; Infant* ; Male ; Purpura ; Purpura, Schoenlein-Henoch* ; Skin ; Vasculitis, Leukocytoclastic, Cutaneous

Segmental testicular infarction is an uncommon and usually idiopathic phenomenon. Some case reports have linked segmental infarction to sickle cell anemia, hypersensitivity angiitis, polycythemia, and an idiopathic cause. Magnetic resonance imaginge (MRI) might be of great diagnostic value as the ischemic lesions have a characteristic pattern. Nonetheless, as its clinical and radiological presentation may resemble testicular tumors, a definite diagnosis can only be established following surgery. We report a case of testicular infarction which presented as a malignancy even in the frozen biopsy.
Anemia, Sickle Cell ; Biopsy ; Diagnosis ; Infarction* ; Magnetic Resonance Imaging ; Polycythemia ; Testicular Neoplasms* ; Testis ; Vasculitis, Leukocytoclastic, Cutaneous