1.Systemic Inflammation in Older Adults With Asthma-COPD Overlap Syndrome.
Juan Juan FU ; Vanessa M MCDONALD ; Peter G GIBSON ; Jodie L SIMPSON
Allergy, Asthma & Immunology Research 2014;6(4):316-324
PURPOSE: The role of systemic inflammation on asthma-COPD overlap syndrome is unknown. This study aimed to examine systemic inflammation in asthma-COPD overlap syndrome, and to identify associations between clinical characteristics and inflammatory mediators in asthma-COPD overlap syndrome. METHODS: In 108 adults older than 55 years comprising healthy controls (n=29), asthma (n=16), COPD (n=21) and asthma-COPD overlap syndrome (n=42), serum high sensitivity C-reactive protein and Interleukin 6 (IL-6) were assayed. Spirometry, induced sputum, quality of life, comorbidities and medications were assessed, and their associations with asthma-COPD overlap syndrome were analyzed using logistic regression. Associations between systemic inflammatory mediators and clinical characteristics were tested in multivariate linear regression models. RESULTS: Patients with asthma-COPD overlap syndrome had significantly elevated IL-6 levels compared with healthy controls and asthmatics. Age, comorbidity index and IL-6 level were independently associated with asthma-COPD overlap syndrome. FEV1% predicted was inversely associated with IL-6 level, and cardiovascular disease was associated with an increased IL-6 level. Systemic markers were not associated with airway inflammation. CONCLUSIONS: Systemic inflammation is commonly present in asthma-COPD overlap syndrome, and asthma-COPD overlap syndrome resembled COPD in terms of systemic inflammation. IL-6 is a pivotal inflammatory mediator that may be involved in airflow obstruction and cardiovascular disease and may be an independent treatment target.
Adult*
;
Asthma
;
C-Reactive Protein
;
Cardiovascular Diseases
;
Comorbidity
;
Humans
;
Inflammation*
;
Interleukin-6
;
Linear Models
;
Logistic Models
;
Pulmonary Disease, Chronic Obstructive
;
Quality of Life
;
Spirometry
;
Sputum
2.Systemic Inflammation in Older Adults With Asthma-COPD Overlap Syndrome.
Juan Juan FU ; Vanessa M MCDONALD ; Peter G GIBSON ; Jodie L SIMPSON
Allergy, Asthma & Immunology Research 2014;6(4):316-324
PURPOSE: The role of systemic inflammation on asthma-COPD overlap syndrome is unknown. This study aimed to examine systemic inflammation in asthma-COPD overlap syndrome, and to identify associations between clinical characteristics and inflammatory mediators in asthma-COPD overlap syndrome. METHODS: In 108 adults older than 55 years comprising healthy controls (n=29), asthma (n=16), COPD (n=21) and asthma-COPD overlap syndrome (n=42), serum high sensitivity C-reactive protein and Interleukin 6 (IL-6) were assayed. Spirometry, induced sputum, quality of life, comorbidities and medications were assessed, and their associations with asthma-COPD overlap syndrome were analyzed using logistic regression. Associations between systemic inflammatory mediators and clinical characteristics were tested in multivariate linear regression models. RESULTS: Patients with asthma-COPD overlap syndrome had significantly elevated IL-6 levels compared with healthy controls and asthmatics. Age, comorbidity index and IL-6 level were independently associated with asthma-COPD overlap syndrome. FEV1% predicted was inversely associated with IL-6 level, and cardiovascular disease was associated with an increased IL-6 level. Systemic markers were not associated with airway inflammation. CONCLUSIONS: Systemic inflammation is commonly present in asthma-COPD overlap syndrome, and asthma-COPD overlap syndrome resembled COPD in terms of systemic inflammation. IL-6 is a pivotal inflammatory mediator that may be involved in airflow obstruction and cardiovascular disease and may be an independent treatment target.
Adult*
;
Asthma
;
C-Reactive Protein
;
Cardiovascular Diseases
;
Comorbidity
;
Humans
;
Inflammation*
;
Interleukin-6
;
Linear Models
;
Logistic Models
;
Pulmonary Disease, Chronic Obstructive
;
Quality of Life
;
Spirometry
;
Sputum