3.The surveillance analysis of the adverse events following immunization of the domestic 13-valent pneumococcal polysaccharide conjugate vaccine in Zhejiang Province.
Yu HU ; Zhen HUANG ; Ying WANG ; Hui LIANG ; Xue Jioa PAN ; Ya Ping CHEN ; Lin YUAN ; Shu Yuan YANG ; Jing Jing CHEN ; Yuan Yuan CHEN ; Xue Mei YAN ; Qian TAO ; Xi QIN ; Hua Kun LYU
Chinese Journal of Preventive Medicine 2022;56(11):1625-1629
To evaluate the safety of the domestic 13-valent pneumococcal polysaccharide conjugate vaccine-tetanus toxoid protein (PCV13-TT) after its licensure. The adverse event following immunization (AEFI) and the vaccination data of PCV13-TT in Zhejiang province from July 2020 to October 2021 were collected from national adverse event following immunization surveillance system and Zhejiang provincial immunization information system. Descriptive epidemiological method was used for this analysis. From July 2020 to October 2021, 302 317 doses of PCV13-TT were administered in children under 6 years old in Zhejiang Province and 636 AEFI case reports were received, with a reporting rate of 21.04 per 10 000 doses. Of these AEFI cases, 97.17% were mild vaccine product-related reaction (20.54 per 10 000 doses) and 95.44% occurred in the 0-1 d after vaccination (20.08 per 10 000 doses). The most common clinical diagnoses of AEFI included fever (224 cases), redness (204 cases), and induration (190 cases), while allergic rash (11 cases) was the most common diagnosis among the abnormal reactions. In conclusion,the present results bolstered that the domestic PCV13-TT was generally well tolerated in children under 6 years old in Zhejiang Province.
Child
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Humans
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Child, Preschool
;
Vaccines, Conjugate/adverse effects*
;
Pneumococcal Vaccines/adverse effects*
;
Vaccination
;
Immunization
;
Polysaccharides
4.The Adverse Effect of the 2-1-1 Regimen for Rabies PEP in Preschool Children.
Shu Qing LIU ; Xiao Yan TAO ; Peng Cheng YU ; Chun Qiu JIN ; Hong Jie YU ; Mei Shun CHEN ; Wu Yang ZHU
Biomedical and Environmental Sciences 2017;30(5):373-375
Post-exposure prophylaxis (PEP) has proved to be the most important measure for rabies prevention and control. There is little information regarding adverse reactions to the Essen and 2-1-1 regimens in preschool children (aged 0-6). We reexamined the outcomes of 1,109 preschool children who were vaccinated using SPEEDA under the Essen regimen between January 2011 and December 2012 and 1,267 preschool children under the 2-1-1 regimen between January 2013 and December 2014. We find that, in preschool children, the febrile reaction after the first 2-dose injection in the 2-1-1 regimen was significantly higher than that induced by the first 1-dose in the Essen procedure. Thus, we recommend that the Essen regimen should still be used for rabies PEP in preschool children.
Child
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Child, Preschool
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Germany
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Humans
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Infant
;
Post-Exposure Prophylaxis
;
standards
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Rabies
;
prevention & control
;
Rabies Vaccines
;
adverse effects
;
Vaccination
;
adverse effects
6.A case of vitiligo after COVID-19 vaccination: a possible role of thymic dysfunction.
Denis KUZNETSOV ; Oleg KALYUZHIN ; Andrey MIRONOV ; Valery NESCHISLIAEV ; Anastasiia KUZNETSOVA
Journal of Zhejiang University. Science. B 2023;24(12):1141-1150
During the coronavirus disease 2019 (COVID-19) pandemic, vaccines help control the spread of infection. To date, 47 vaccines have been approved, with another 227 candidates in various stages of development. In the short period of time since the beginning of their use, evidence has begun to emerge of complications following vaccination in the form of the development or exacerbation of a number of pathological conditions (Block et al., 2022; Haseeb et al., 2022). For example, a population-based study in France identified 1612 cases of myocarditis and 1613 cases of pericarditis requiring hospital treatment within five months of vaccination (le Vu et al., 2022).
Humans
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COVID-19/prevention & control*
;
COVID-19 Vaccines/adverse effects*
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Vaccination/adverse effects*
;
Vitiligo/etiology*
;
Thymus Gland/physiopathology*
7.Efficacy of sweet solutions in relieving pain caused by vaccination in infants aged 1 to 12 months: a systematic review.
Shao-Lin CHEN ; Harrison DENISE ; Rui-Rui HUANG ; Qing ZHANG ; Ri-Hua XIE ; Shi-Wu WEN
Chinese Journal of Contemporary Pediatrics 2016;18(6):534-540
OBJECTIVETo investigate the efficacy of oral sweet solutions in relieving pain caused by vaccination in infants aged 1 to 12 months.
METHODSRelated databases were searched to find related randomized control trails (RCTs). The quality of these RCTs was evaluated. The Meta analysis was performed using RevMan 5.3.
RESULTSA total of 20 RCTs involving 2 376 infants were included, and quality assessment showed that 6 RCTs had grade A quality and 14 had grade B quality. The Meta analysis showed that compared with sterile water, 25%-75% oral sweet solution significantly reduced crying time (WMD=-21.16, 95%CI -39.66 to -2.77, P<0.05) and the proportion of crying time (the duration of crying /3-minute periods after the injection) (WMD=-13.83, 95%CI -20.88 to -6.78, P<0.01), while the crying time showed no significant difference between the group treated with oral administration of 12% sucrose solution and non-intervention group. Co
ONCLUSIONSOral sweet solution (25%-75%; 2 mL) given 2 minutes before vaccination can effectively relieve the pain caused by vaccination in infants aged 1-12 months.
Crying ; Humans ; Infant ; Pain ; prevention & control ; Solutions ; Sucrose ; administration & dosage ; Vaccination ; adverse effects
8.Management of children after renal transplantation: highlights for general pediatricians.
Keith K LAU ; Lucy GIGLIA ; Howard CHAN ; Anthony K CHAN
Chinese Journal of Contemporary Pediatrics 2012;14(2):81-88
The number of children undergoing successful renal transplantations has been increasing steadily and as a result, general pediatricians are now more likely to encounter children with a kidney allograft in their practice. Although the medical care immediately after transplantation is mostly provided by transplant teams, more and more outpatient care will eventually be performed at the patient's local community. Medical care from general pediatricians is particularly important, especially for children who are residing far from transplant centers. As these children require prolong immunosuppressive therapies and are susceptible to various specific clinical problems, it is imperative for their primary care providers and pediatricians to be knowledgeable about their specific needs and be competent in providing care. This article highlights the roles and common practice related issues that pertain to general pediatricians in the care of pediatric renal allograft recipients.
Child
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Humans
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Immunosuppressive Agents
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therapeutic use
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Kidney Transplantation
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adverse effects
;
psychology
;
Pediatrics
;
Vaccination
9.Immune control strategies for vaccinia virus-related laboratory-acquired infections.
Qiang WEI ; Meng Nan JIANG ; Jun HAN ; Zi Jun WANG
Biomedical and Environmental Sciences 2014;27(2):142-146
While presenting biological characteristics of vaccinia virus and laboratory-acquired infections during related research processes, this paper focuses on benefits and risks of vaccinia virus immunization in relation to laboratory-acquired infections, describes characteristics and the adaptation of vaccinia virus vaccine, analyses the role vaccinia virus immunization plays in the prevention and control of laboratory-acquired infections, and finally proposes solutions and countermeasures to further promote and implement immune control strategies. The problem related to immune strategy and laboratory- acquired infections which is being raised, analyzed and explored plays an active and instructive role in vaccinia virus related researches and laboratory- acquired infections, and also helps to recommend and develop relevant immune strategy for future vaccine control of such infections.
Contraindications
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Humans
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Smallpox Vaccine
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adverse effects
;
Vaccination
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standards
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Vaccinia
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immunology
;
prevention & control
;
Vaccinia virus
;
immunology