Ocular inflammation from various causes may have similar clinical presentation thus careful clinical evaluations are mandatory particularly when the disease appear to be resistant to treatment. This paper reports a case of ocular lymphoma which was initially treated as Vogt Koyanagi Harada disease at a different centre. A 65-year-old Sudanese man complained of gradual worsening left eye vision. Careful ocular and slit lamp examination revealed a conjunctival lesion with choroidal infiltration as well as exudative retinal detachment. Computed tomography scan (CT scan) showed left eye axial proptosis, and a homogenous enhancing mass at the posterior coat of the globe. Tissue biopsy of the conjunctival lesion revealed marginal Zone B cell (MALT type), low grade, non-Hodgkin’s lymphoma. AS the ocular signs and symptoms progressed, chemotherapy was initiated. The proptosis, exudative retinal detachment, disc hyperemia and swelling improved after chemotherapy. The post treatment CT scan showed reduction of the posterior ocular coat mass. The possibility of malignant lymphoma should be considered in patients with resistant uveitis despite administration of corticosteroid. Ocular lymphoma is an indolent tumour with good prognosis. Careful ocular examination, adequate imaging studies followed by early surgical biopsy will contribute to early diagnosis.
Uveomeningoencephalitic Syndrome

No abstract available.
Hearing Loss* ; Hearing* ; Uveomeningoencephalitic Syndrome*

No abstract available.
Adalimumab ; Adult ; Female ; Humans ; Uveomeningoencephalitic Syndrome

PURPOSE: We analyzed the clinical features of patients with recurrent Vogt-Koyanagi-Harada(VKH) syndrome. METHODS: A retrospective chart review of 21 patients diagnosed with VKH syndrome between 1994 and 2004 was performed. We grouped the patients into two groups according to the duration of ocular inflammation. Group A included patients with recurrent ocular inflammation lasting 24 months or longer and Group B included those with a duration of less than 24 months. We compared the clinical manifestations, responses to treatment and complications. RESULTS: Group A had 7 patients and Group B had 14 patients. There were significant differences in initial visual acuity, the interval between ocular symptoms and treatment, total steroid dose, and complications. The average final visual acuity of Group A was 0.572 (0.2-1.0), which was relatively favorable. CONCLUSIONS: The initial visual acuity and the interval between ocular symptoms and treatment seemed to be important predictors. We conclude that aggressive treatment is necessary in recurrent VKH syndrome, as visual prognosis was relatively favorable despite the cost of the problems associated with high dose steroids and ocular complications.
Humans ; Inflammation ; Prognosis ; Retrospective Studies ; Steroids ; Uveomeningoencephalitic Syndrome* ; Visual Acuity

We have experienced a case of Vogt-Koyanagi-Harada Syndrome in 35 years-old male. The Voght-Koyanagi-Harada Syndrome is characterized by severe chronic bilateral Ilveitis associated with alopecia, poliosis, vitiligo and signs of meningeal irritation. In presented case, there was extensive posteriar synechia, numerous mutton fat K.P. in addition to cataract, poliosis, vitiligo, headache and dysacousia. Steroid was administered over period of 6 monthes in gradual decreasing dosage, but there was no appearent effect on the course of the disease.
Adult ; Alopecia ; Cataract ; Headache ; Humans ; Male ; Uveomeningoencephalitic Syndrome* ; Vitiligo

VKH syndrome is a symptom complex having prodromal systemic manifestations, bilateral uveites and exudative retinal detachment. It has not been known clearly whether it is relelated to DM or not. We experienced a 43-year old man complaining of acutely decreased visual acuity in both eyes with bilateral choroidal detachment. He has been diabetic for 5 years in uncontrolled state. He was diagnosed to have VKH syndrome and was treated with local steroid injection with visual improvement. So we present this case with review of literatures.
Adult ; Choroid* ; Humans ; Retinal Detachment ; Uveomeningoencephalitic Syndrome ; Visual Acuity

Besides meningism, dizziness has also been frequently reported as a neurologic manifestation of Vogt- Koyanagi-Harada(VKH) syndrome. These neurotologic symptoms usually develop just before or after ocular involvement. We report the patient with VKH syndrome who showed recurrent peripheral vertigo. The characteristic opthalmological symptoms developed later in this case.
Dizziness ; Humans ; Meningism ; Neurologic Manifestations ; Uveomeningoencephalitic Syndrome* ; Vertigo*

A case of Vogt-Koyanagi-Harada syndrome was presented with some clinical observation. Special feature was the presence of cyst-like elevated portions at the peripheral iris, in addition to secondary glaucoma, alopecia, poliosis and vitiligo. Of the iris, the surface of elevated portion was thin and depigmented. A light red fundus reflex was observed through the surface of iris cyst as in case of the albino and neovascularization was seen in the peripheral iris. Neither hyperglycemia in blood nor pleocytosis of spinal fluid was found in laboratory examination. In neurological examination including hearing disturbance, none of abnormality was found.
Alopecia ; Glaucoma ; Hearing ; Hyperglycemia ; Iris ; Leukocytosis ; Neurologic Examination ; Reflex ; Uveomeningoencephalitic Syndrome* ; Vitiligo

This 21 year old male visited our hospital on April 1972, with complaints of visual disturbance in both eyes, vitiligo, poliosis and alopecia. He was admitted to our department of ophthalmology for 7 days. He had uveitis in both his eyes and vitiligo on the face and hand, poliosis, alopecia were noted. Slight sensory hearing disturbance on audiography, pleocytosis of spinal fluid, and mild dysrhythmic abnormality on E.E.G. were found. Thus this case is presented as a complete form of Vogt-Koyanagi-Harada syndrome, which is characterized by ocular, meningeal, vestibular, cochlear and dermal changes.
Alopecia ; Hand ; Hearing ; Humans ; Leukocytosis ; Male ; Ophthalmology ; Uveitis ; Uveomeningoencephalitic Syndrome* ; Vitiligo ; Young Adult

Vogt-Koyanagi-Harada (VKH) syndrome is an idiopathic autoimmune disease involving melanocytes. The characteristic features are uveitis, meningismus, tinnitus, alopecia, vitiligo and poliosis, dependent upon the site of melanocyte location. Among the skin manifestations, alopecia usually appears as discrete, alopecic patches around the head. We report a case of fifty-year-old woman who presented with typical features of VKH syndrome, plus alopecia universalis and nail dystrophy.
Alopecia* ; Autoimmune Diseases ; Female ; Head ; Humans ; Melanocytes ; Meningism ; Skin Manifestations ; Tinnitus ; Uveitis ; Uveomeningoencephalitic Syndrome* ; Vitiligo