We performed standard pars plana vitrectomies in 17 eyes with uveitis which were complicated with vitreous opacities. Postoperatively, visual acuity was improved in 11 eyes(64.7%),maintained in4 eyes(23.5%) and decreased in 2 eyes (11.8%). Four weeks after vitrectomy, inflammatory cells were rarely noticed in the anterior vitreous of all eyes. We suggest that early surgical approach is of value for visual improvement in the management of uvitis eyes with vitreous opacity.
Uveitis ; Uveitis, Intermediate* ; Visual Acuity ; Vitrectomy*

Since Ernst Fuchs had described the chronic cyclitis as cyclitis in 1892, there have been many reports about the chronic cyclitis with the development of the binocular indirect ophthalmoscope and the Schepens' scleral depressor and gonioscope. The chronic cyclitis comes incidious onset with minimal symptoms of hazy vision and vitreous opacity. The authors experienced a case of chronic cyclitis of the left eye of 33 year old male patient who has been treated with systemic corticosteroid and antihistamines. Here, we briefly report it referring the literature about the chronic cyclitis.
Adult ; Histamine Antagonists ; Humans ; Male ; Ophthalmoscopes ; Telescopes ; Uveitis, Intermediate*

PURPOSE: Despite ocular immune privilege, noninfectious chronic uveitis is relatively common. To investigate spontaneous turning on and off of noninfectious chronic uveitis, we examined the nature and apoptosis of infiltrating inflammatory cells from the anterior chamber of patients with chronic uveitis. METHODS: Aqueous humors were obtained with consent from patients with chronic recurrent uveitis at the time of active intraocular inflammation. Apoptosis of the infiltrating cells in aqueous humor was analyzed by flow cytometry, using fluorescence-labeled anti-CD95 antibody, anti-CD95L antibody, and Annexin V. RESULTS: Of total 35 patients recruited, 19 patients had anterior uveitis, 4 patients had intermediate uveitis, and 12 patients had panuveitis. The proportions of Fas+cell and FasL+ cell were over 90% independent of clinical characteristics of uveitis. Annexin V+ cells occupied 31.3% of all cells in aqueous humor. CONCLUSION: The high proportions of CD95+ cell, CD95L+ cell, Annexin+ cell suggest that there is an active apoptosis of inflammatory cells in anterior chamber of noninfectious chronic uveitis.
Annexin A5 ; Anterior Chamber* ; Apoptosis ; Aqueous Humor ; Flow Cytometry ; Humans ; Inflammation ; Panuveitis ; Uveitis* ; Uveitis, Anterior ; Uveitis, Intermediate

Sarcoidosis is a granulomatous disease which frequently involves eyes and adnexal tissues. Its prevalence of ocular involvement is reported as about 20%, although it varies widely according to authors, from 12% to 73%. Ocular sarcoidosis is present as various forms - uveitis, conjunctival involvement, optic nerve involvement, and orbital involvement. All the forms of uveitis - anterior uveitis, intermediate uveitis, posterior uveitis and panuveitis - can be shown in sarcoidosis. Because clinical manifestation, prognosis and treatment are determined by the location of uveitis, it is important to classify uveitis. Conjunctival involvement is not a sight-threatening condition in general, its diagnostic value may be of use. Optic nerve is the most commonly involved cranial nerve, which can impair vision. Subjects with visual impairment without any evidence of uveitis, optic nerve involvement should be suspected. Orbital involvement, especially lacrimal gland involvement is common, and it may cause mass-effect. Besides systemic administration of drugs, there are several localized treatments for ocular sarcoidosis - topical eye drops, intra/peri-ocular injection of agents.
Cranial Nerves ; Granuloma ; Lacrimal Apparatus ; Ophthalmic Solutions ; Optic Nerve ; Orbit ; Panuveitis ; Prevalence ; Prognosis ; Sarcoidosis* ; Uveitis ; Uveitis, Anterior ; Uveitis, Intermediate ; Uveitis, Posterior ; Vision Disorders

The chronic cyclitis was first described under the designation of cyclitis by Ernst Fuchs in 1892, having been described as peripheral uveitis and pars planitis. The etiopathogenic nature of chronic cyclitis has been in controversy but the role of allergy is suggested in this disease entity, The inflammatory process starts at ciliary body and peripheral chorioretina, extends to anterior chamber and vitreous. It is incidious, bilateral and recurrent, affects young individuals. This condition begins with minimal symptoms of hazy vision and vitreous opacity, may result in serious visual disturbances due to various complications including cataract, macular degeneration, retinal detachment, glaucoma and phthisis bulbi. A 50 year old man was found to have chronic cyclitis in his left eye that was treated with antituberculous agents and sub-Tenon's injection of corticosteroid agent.
Anterior Chamber ; Cataract ; Ciliary Body ; Glaucoma ; Humans ; Hypersensitivity ; Macular Degeneration ; Middle Aged ; Pars Planitis ; Retinal Detachment ; Uveitis* ; Uveitis, Intermediate*

In order to investigate the efficiency of various laboratory studies of uveitis, we performed a series of studies including complete boold count, immunologic tests and radiolgic examination for 70 patients with uveitis and same number of controls who had visited at St. Mary's Hospital, Catholic University Medical College from October 1992 to May 1993. The series of uveitis consists of 24 patients(34.3%) of anterior uveitis, 20 patients(28.6%) of posterior uneitis and 17 patients(24.3%) of intermediate uveitis. Only 7 cases presented positive results for the specific laboratory studies. Two patients of uveitis were positive for cytomegalovirus IgM, one for toxoplasma IgG and one for VDRL. One patient showed evidence of sacroilitis on sacroiliac joint X-ray. Skin test for Clonorchis sinensis was positive in one patient of uveitis. One case in the control group was positive for toxoplasma IgG. From the above results, we suggest that the selective laboratory studies should be carried out on the basis of the patient's histories and ocular findings for the more specific and etiological diagnosis of uveitis.
Clonorchis sinensis ; Cytomegalovirus ; Diagnosis ; Humans ; Immunoglobulin G ; Immunoglobulin M ; Immunologic Tests ; Sacroiliac Joint ; Skin Tests ; Toxoplasma ; Uveitis* ; Uveitis, Anterior ; Uveitis, Intermediate

In order to evaluate association of particular HLA typing with certain uveitis in Korean population, HLA antigens were analyzed in 114 uneitis patients(acute anterior uveitis: 32 cases, Behcet`s disease: 25 cases, intermediate uveitis: 19 cases, Vogt-Koyanagi-Harada (V-K-H) syndrome: 10 cases, retinal vasculitis: 12 cases, Eale`s disease: 3 cases, posterior uveitis: 9 cases, pan.uveitis: 4 cases). The stronger association between acute anterior uveitis and HLA-B27 was statistically significant, and this result was similar to reports in other ethnic groups. Also, the association between V-K-H syndrome and HLA-DR4 showed same results. But the high frequency of HLA-DR7 in the patients with V-K-H syndrome was unque in patients of Korean popjlation and statistically significant. The association between HLA-A2 and posterior uveitis was high in patients of Korean population and statistically significant. Behcet`s disease was stronger association with HLA-B51 but not statistically significant and much weaker association than reports in Japanese group. Although many similarities of associations between particular uveitis and HLA typing were detected as compared with other ethnic groups, distinctive HLA associations were demonstrated in Korean population. Additional cases and long-term follow-up are required to confirm the association with HLA typing and the relationship with prognosis including clinical and laboratory variabilities.
Asian Continental Ancestry Group ; Ethnic Groups ; Follow-Up Studies ; Histocompatibility Testing ; HLA Antigens ; HLA-A2 Antigen ; HLA-B27 Antigen ; HLA-B51 Antigen ; HLA-DR4 Antigen ; HLA-DR7 Antigen ; Humans ; Prognosis ; Retinal Vasculitis ; Uveitis* ; Uveitis, Anterior ; Uveitis, Intermediate ; Uveitis, Posterior

Nd-YAG laser is known as a safe and effective treatment for posterior capsular opacity after cataract surgery. We studied the ocular complications after Nd-YAG laser treatment in uveitis patients. From January 1991 to December 1996, we retrospectively investigated the complications of uveitis in 22 persons(25 eyes) after Nd-YAG laser posterior capsulotomy, and also investigated that of nonuveitis in 563 persons(635 eyes) as a control group. The uveitis cases consisted of six anterior uveitis, eight intermediate uveitis, seven Behcet`s syndromes, three panuveitis, and one posterior uveitis. In the uveitis group, the complications(18 eyes) consisted of three retinal detachments, one giant retinal tear, three glaucoma, two aggravations of uveitis, two vitreous opacities, one retinal emorrhage, one proliferative vitreoretinopathy, one hyphema, and four transient high intraocular pressures(IOP), and in the control group, it consisted of two subluxations of intraocular lens(IOL), three glaucomas, one retinal tear, three transient high IOPs, two vitreous opacities, two retinal hemorrhages, three macular holes, two retinal detachments, and five cystoid macular edemas. From our experience, the incidence of complications after Nd-YAG laser posterior capsulotomy in uveitis was higher than that in nonuveitis. It was also noted that it is necessary to follow up thoroughly the complications after Nd-YAG laser posterior capsulotomy in uveitis patients.
Cataract ; Follow-Up Studies ; Glaucoma ; Humans ; Hyphema ; Incidence ; Lasers, Solid-State* ; Macular Edema ; Panuveitis ; Posterior Capsulotomy* ; Retinal Detachment ; Retinal Hemorrhage ; Retinal Perforations ; Retinaldehyde ; Retrospective Studies ; Uveitis* ; Uveitis, Anterior ; Uveitis, Intermediate ; Uveitis, Posterior ; Vitreoretinopathy, Proliferative

C4 glomerulopathy is a recently introduced entity that presents with bright C4d staining and minimal or absent immunoglobulin and C3 staining. We report a case of a 62-year-old man with C4 glomerulonephritis (GN) and uveitis. He presented to the nephrology department with proteinuria and hematuria. The patient also had intermediate uveitis along with proteinuria and hematuria. A kidney biopsy that was performed in light of continuing proteinuria and hematuria showed a focal proliferative, focal sclerotic glomerulopathy pattern on light microscopy, absent staining for immunoglobulin or C3 by immunofluorescence microscopy, with bright staining for C4d on immunohistochemistry, and electron-dense deposits on electron microscopy. Consequently, C4 GN was suggested as the pathologic diagnosis. Although laser microdissection and mass spectrometry for glomerular deposit and pathologic evaluation of the retinal tissue were not performed, this is the first report of C4 GN in Korea and the first case of coexisting C4 GN and uveitis in the English literature.
Biopsy ; Diagnosis ; Glomerulonephritis* ; Hematuria ; Humans ; Immunoglobulins ; Immunohistochemistry ; Kidney ; Korea ; Mass Spectrometry ; Microdissection ; Microscopy ; Microscopy, Electron ; Microscopy, Fluorescence ; Middle Aged ; Nephrology ; Proteinuria ; Retinaldehyde ; Uveitis ; Uveitis, Intermediate*

PURPOSE: To describe the clinical manifestations and treatment outcomes of ocular syphilis in patients without human immunodeficiency virus (HIV) infection. METHODS: A total of 45 eyes from 39 patients with ocular syphilis confirmed by serologic tests were reviewed retrospectively. The included cases were all non-HIV-infected patients presenting with intraocular inflammation from 2002 to 2014 at Kyung Hee University Hospital. Medical records of 45 eyes were analyzed and included best-corrected visual acuity and ophthalmologic examination findings of the anterior and posterior segments to determine the focus of inflammation. Optical coherence tomography and fluorescein angiography findings as well as both medical and surgical management were also analyzed. RESULTS: The mean patient age was 61.0 years (range, 37 to 89 years). Bilateral ocular involvement occurred in 6 patients (15.4%), and diagnoses at presentation were most frequently related to posterior uveitis (38%), followed by panuveitis (29%) and optic neuritis (11%). Isolated interstitial keratitis and intermediate uveitis were uncommon (4%, both). Twenty-eight eyes (62.2%) were treated with penicillin, and 11 eyes (24.4%) underwent surgical treatment. The mean baseline best corrected visual acuity was 0.79 ± 0.59 (mean ± standard deviation, logarithm of the minimum angle of resolution) and significantly improved to 0.60 ± 0.63 at the final follow-up after treatment (p = 0.019). Mean visual improvement was significantly greater in the penicillin-treated group (p = 0.001). Visual impairment at the final visit occurred in 11 eyes (24.4%). Among the visual impairment group, 10 eyes (90.1%) had posterior segment-involving uveitis. CONCLUSIONS: Visual outcomes of treated, non-HIV-related ocular syphilis were favorable regardless of time to presentation. Posterior segment-involving uveitis at presentation was associated with poor visual outcome.
Diagnosis ; Fluorescein Angiography ; Follow-Up Studies ; HIV ; Humans ; Inflammation ; Keratitis ; Medical Records ; Optic Neuritis ; Panuveitis ; Penicillins ; Retrospective Studies ; Serologic Tests ; Syphilis* ; Tomography, Optical Coherence ; Uveitis ; Uveitis, Intermediate ; Uveitis, Posterior ; Vision Disorders ; Visual Acuity