In this paper I report the two cases of Dannheim's anterior chamber lens operation in the monocular aphakic patient for the first time in Korea. The first case(19 years old male patient with traumatic cataract in his left eye) had been {)perated on July 10, 1960. After operation his corrected visual acuity was 0.8 wearing glass (Sph. +12.00D.). On Aug. 2S, 1960 he had taken another operation for the insertion of Dannheim's anterior chamber lens (power; +12.50D., size; 12.5mm.). On Oct. 8. 1960 the visual acuity was 0.9 with adding Sph. -5.50D. glass in front of his left eye. Through the slit lamp examination the loop of the anterior chamber lens was well fixed into the chamber angle and remained in situ. He has carried a very comfortable life without any remarkable trouble for 16 years untill nowadays. The second case (50 years old male patient with senile cataract complicated by secondary glaucoma in his left eye) had been operated intracapsullary on Jan. 15, 1960. After cataract operation he had used corneal contact lens and his corrected visual acuity for distant was 1.5 (Sph. +14.50D. Rad. 7.8) and I.O.P. was within normal limit. 9 years after cataract operation he refused to wear contact lens due to discomfortness and therefore he had reoperated to insert Dannheim's anterior chamber lens (same as case 1.) on Sept. 10. 1969. After operation his visual acuity was 0.8 for distant vision, but slight movement of the anterior chamber lens was noticed by slit lamp examination. On Jan. 12. 1970. he had had moderate iritis and slightly elevated I.O.P. (20.6mmHg.). Those symptoms had subsided after 7 day's treatment by local instillation of 2% T-pilocarpine sol. and oral acetazolamide and corticosteroid medication. On March 7, 1973. he revisited my clinic due to a severe ocular pain in his left eye. At that time the I.O.P. was 30mmHg. and the visual acuity was reduced to 0.04 due to severe anterior uveitis. And so I removed the anterior chamber lens on March 8. 1973. The Fixation of anterior chamber lens into the filtration angle is very important factor for the determination of the prognosis of operation. The continuous experiment and development of the method to fix the loop of the anterior chamber lens into the filtration angle is required for the sake of successful operation.
Acetazolamide ; Anterior Chamber* ; Cataract ; Filtration ; Glass ; Glaucoma ; Humans ; Iritis ; Korea ; Male ; Prognosis ; Uveitis, Anterior ; Visual Acuity

PURPOSE: To report a case of intraocular cilium revealed by diagnostic vitrectomy in a case of stubborn uveitis that was unresponsive to steroid therapy. CASE SUMMARY: A 39-year-old man was referred to our hospital due to decreased vision in his right eye that started two months prior to presentation. He had previously been treated for a diagnosis of iridocyclitis. The patient's history revealed a blunt trauma to the right eye while wearing glasses after which he developed a microhyphema and was treated for traumatic iritis at another clinic 3 months ago. He was treated with topical and oral steroids after being diagnosed with iridocyclitis and had recently been prescribed additional oral cyclosporine because his condition had not improved. Ocular examination revealed inflammatory cells in the anterior chamber and vitreous cavity with hand motion vision. Ultrasonography revealed a hazy vitreous cavity but the retina was flat. Diagnostic vitrectomy with intravitreal antibiotic injection was performed and an intraocular foreign body presumed as a cilium was detected without an entrance wound on the exterior or interior surface of the eye. After removal of the foreign body, the patient's vision was completely recovered. CONCLUSIONS: In cases of chronic uveitis that do not respond to immunosuppressive treatment without a clearly definable cause, diagnostic vitrectomy should be considered, keeping in mind the possibility of intraocular foreign body.
Adult ; Anterior Chamber ; Cilia ; Cyclosporine ; Endophthalmitis ; Eye ; Eyeglasses ; Foreign Bodies ; Glass ; Hand ; Humans ; Iridocyclitis ; Iritis ; Retina ; Steroids ; Uveitis ; Vision, Ocular ; Vitrectomy

Behcet syndrom is a chronic systemic disease developing recurrent oral and genital ulceration, ocular inflammation, arthritis and neurological manifestations. Anterior uveitis and occlusive retinal vasculitis are the most commom ocular manifestation of Behcet syndrome. A 29 years old Korean male with abducens palsy (6th cranial nerve palsy) was found to have oral aphthae, genital ulcer, skin lesion and other neurological manifestations (weakness and sensory loss of lower extremeties, ataxic gait, speech disturbance and urinary difficulty), but he had neither ocular manifestation such as uveitis nor retinal vasculitis.
Adult ; Arthritis ; Behcet Syndrome ; Cranial Nerves ; Gait ; Humans ; Inflammation ; Male ; Neurologic Manifestations ; Paralysis* ; Retinal Vasculitis ; Skin Ulcer ; Stomatitis, Aphthous ; Ulcer ; Uveitis ; Uveitis, Anterior

Behcet's disease is a chronic, relapsing, inflammatory multisystem disorder characterized by recurrent oral and genital ulcerations along with eye lesions (anterior uveitis, posterior uveitis, cells in vitreous on slit lamp examination, retinal vasculitis observed by ophthalmologist), skin lesions (erythema nodosum, pseudofolliculitis, papulopustular lesions, acneiform nodules), arthralgia, central nervous system and vascular involvement, and gastrointestinal manifestations. The etiology of Behcet's disease remains unknown. We report a case of a 48-year-old male with a 25-year-history of blindness, recurrent ulcers on mucosal surfaces, and papulopustular lesions on the trunk. Dapsone is an easily available, cheap and relatively safe drug, useful particularly in the management of the mucocutaneous symptoms of Behcet's disease. Dapsone 100 mg was given daily for one month which resulted in improvement of skin and mucosal lesions. Early diagnosis and treatment of this condition is important to prevent irreversible organ damage and mandatory to reduce mortality and morbidity.

Human ; Male ; Middle Aged ; Arthralgia ; Behcet Syndrome ; Blindness ; Dapsone ; Early Diagnosis ; Erythema Nodosum ; Ophthalmologists ; Retinal Vasculitis ; Skin ; Slit Lamp Microscopy ; Ulcer ; Uveitis, Anterior ; Uveitis, Posterior

Optic disc neovascularization is known to occur in occlusive vascular diseases or chronic posterior inflammatory conditions. It has been recently reported to occur in chronic anterior uveitis. The authors treated a patient with optic disc neovascularization associated with chronic anterior uveitis with topical and systemic steroid administration. The authors present our experience of optic disc neovascularization in chronic anterior uveitis with a brief review of the literatures related to this disease.
Humans ; Uveitis ; Uveitis, Anterior* ; Vascular Diseases

We conducted a retrospective analysis of 394 patients with uveitis seen at Kyung Hee University Medical Center from January 1982 to June 1987 to determine the frequency of occurence and to study the clinical characteristiscs of various form of uveitis. The results were as follows; 1. In classification of uveitis by location, 309 patients(78.4%) were anterior uveitis, 41 patients(10.4%) were posterior uveitis, 31 cases(7.9%) occurred as panuveitis. Pars planitis accounted for 13 cases(3.3%). Anterior uveitis was the most common causes of uveitis. 2. In cases of anterior uveitis, 127 cases(32.7%) were idiopathic iridocyclitis, 121 cases(30.7%) were traumatic iridocyclitis. In cases of posterior uveitis, Tuberculous uveitis was seen in 11 cases(2.8%), and Toxoplasmic chorioretinitis occured 10 cases(2.5%). In case of panuveitis, Behcet's disease was observed 10 patients(2.5%), and was the most common cause of panuveitis, pars planitis accounted for 13 cases(13.3%). 3. In aspect of age of uveitis, the peak age was 16~45 yrs.(60.6%). In case of anterior uveitis and pars planitis, peak age group was 16~45 yrs. In case of posterior uveitis and panuveitis, peak age group was 31~60 yrs. 4. In clinical characteristics of uveitis by location, anterior uveitis occurred at mostly younger age than did any uveitis(27.8 yrs.) in average age of diagnosis. In sex ratio, male patient of pars planitis predominated with over 3 times number of female patient. In the average duration of illness from the date of first symptom to date of first recorded quiescence, anterior uveitis was mostly shorter duration than did any uveitis(1.1 Mon.). 5. In the evaluation of laterality, all cases showed binocular equal distribution except pars planitis. 6. The largest number of complication was showed in panuveitis. 7. The most common symptom of uveitis was visual disturbance.
Academic Medical Centers ; Chorioretinitis ; Classification* ; Diagnosis ; Female ; Humans ; Iridocyclitis ; Male ; Panuveitis ; Pars Planitis ; Retrospective Studies ; Sex Ratio ; Telescopes ; Uveitis* ; Uveitis, Anterior ; Uveitis, Posterior

PURPOSE: We report a case of spontaneous recovery of an iris cyst with only tuberculosis medication and conservative eye drops when uveitis and angle closure occurred because of a cyst in a patient with peritoneal tuberculosis. CASE SUMMARY: A 49-year-old female who was diagnosed with iritis and treated with steroid eye drops visited our clinic because of decreased visual acuity 1 month prior. There were anterior chamber inflammation cells and an iris cyst completely obstructing the anterior chamber at 12 o'clock. At the time, the patient had been diagnosed with peritoneal tuberculosis in the Department of Internal Medicine and Gynecology and had been treated with surgery and medication. The patient had no past history of glaucoma, but when the iris cyst developed, the intraocular pressure increased to 29 mmHg and anterior inflammatory cells were seen in the range of +1 to +2. The primary lesion of tuberculosis improved and the iris cyst disappeared with treatments involving medication for tuberculosis, steroid eye drops, and glaucoma eye drops, without invasive treatments such as alcohol curettage, laser treatment, or cyst resection. CONCLUSIONS: If an iris cyst is a new lesion of the eye, it is necessary to identify the pattern and cause of the iris cyst first, and if a secondary benign iris cyst is suspected, the primary treatment of the causative disease is necessary rather than prompt invasive treatment.
Anterior Chamber ; Curettage ; Female ; Glaucoma ; Gynecology ; Humans ; Inflammation ; Internal Medicine ; Intraocular Pressure ; Iris ; Iritis ; Middle Aged ; Ophthalmic Solutions ; Peritonitis, Tuberculous ; Tuberculosis ; Uveitis ; Visual Acuity

Recently ankylosing spondylitis have been found to be the most common one among the joint diseases which is associated with anterior uveitis. About 10 to 60% of patients with Marie-Strumpells' ankylosing spondylitis have anterior uveitis. Ankylosing spondylitis is mostly found in young male and characterized by makedly elevated sedimentation and radiological changes; earliest finding in sacro-iliac joints are subchondral sclerosis or demineralization of the bone near the sacro-iliac joints. The joint margins gradually become less distinct until ankylosis develope. The vertebral bodies show "squaring" and the longitudinal ligaments show calcification and ossification on x-ray film (Bamboo spine). The uveitis associated with ankylosing spondylitis is a mild to severe non-granulomatous type (sometimes granulomatous) involving the anterior segment exclusively. Usually it affects one eye at a time. Recurrent attacks may lead to permanent damage depending on the severity and frequency of the attacks and the adequacy of treatment. The main treatment is the administration of steroids. A 35 year old man was seen in our clinic and found to have recurrent anterior uveitis with: hypopyon in his right eye and ankylosing spondylitis while was confirmed by char;acteristic radiological findings. Pathients with acute recurrent non-granulomatous iridocyclitis without apparent cause should have an x-ray of the lumbosacral spine and sacro-iliac joints.
Adult ; Ankylosis ; Humans ; Iridocyclitis ; Joint Diseases ; Joints ; Longitudinal Ligaments ; Male ; Sclerosis ; Spine ; Spondylitis, Ankylosing* ; Steroids ; Uveitis ; Uveitis, Anterior* ; X-Ray Film

PURPOSE: We investigated the suppressive effect of cyclosporine A (CsA) on the recurrence of experimental autoimmune anterior uveitis that mimics human endogenous uveitis in clinical appearance. METHODS: Lewis rats were immunized with melanin-associated antigen and treated with intraperitoneal CsA for one week and then received the second immunization with the same antigen at 8 weeks after primary immunization. The treatment of CsA started either from the day of primary immunization (early treatment group) or from 14 days after the immunization (delayed treatment group). The clinical and histologic grading of the uveitis was assessed in comparison with the control group. RESULTS: In early treatment group, intraocular inflammation developed later than in control group. However the inflammation continued for a longer period. In delayed treatment group, the total period of intraocular inflammation was also increased even though CsA suppressed intraocular inflammation during the treatment period. The recurrence rate of experimental autoimmune anterior uveitis was similar in all groups. CONCLUSIONS: CsA suppressed intraocular inflammation significantly during the treatment period, howerever it did not seem to suppress the recurrence of the experimental uveitis.
Animals ; Cyclosporine* ; Humans ; Immunization ; Inflammation ; Rats ; Recurrence* ; Uveitis ; Uveitis, Anterior*

OBJECTIVE: Acute anterior uveitis (AAU) is the most common extra-articular manifestation in patients with axial spondyloarthritis (axSpA). However, the relationship between AAU and radiographic progression in axSpA remains unclear. Hence, we investigated whether the presence of AAU is associated with radiographic structural damage in patients with axSpA. METHODS: Clinical and radiographic data were obtained from 253 patients with axSpA. Radiographic progression over 2 years was assessed using the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS). Progression was defined as mSASSS worsening by ≥two units. Using propensity score (PS) matching, differences between patients with and without AAU were analyzed. RESULTS: The proportion of progressors among patients with AAU was lower than that of patients without AAU (13.6% vs. 29.5%, p=0.058). The rate of increase in mSASSS and number of syndesmophytes were lower in patients with AAU than patients without AAU (0.57±1.37 vs. 1.02±1.79, p=0.085 and 0.46±1.45 vs. 0.83±1.62, p=0.158). In multivariate regression analysis, presence of AAU was independently associated with slowed radiographic progression (odds ratio [95% confidence interval] 0.21 [0.07, 0.67], p=0.004). CONCLUSION: PS-matched axSpA patients with AAU showed significantly less radiographic progression than those without AAU.
Humans ; Propensity Score ; Spine ; Spondylitis, Ankylosing ; Uveitis ; Uveitis, Anterior