Optic disc neovascularization is known to occur in occlusive vascular diseases or chronic posterior inflammatory conditions. It has been recently reported to occur in chronic anterior uveitis. The authors treated a patient with optic disc neovascularization associated with chronic anterior uveitis with topical and systemic steroid administration. The authors present our experience of optic disc neovascularization in chronic anterior uveitis with a brief review of the literatures related to this disease.
Humans ; Uveitis ; Uveitis, Anterior* ; Vascular Diseases

PURPOSE: We investigated the suppressive effect of cyclosporine A (CsA) on the recurrence of experimental autoimmune anterior uveitis that mimics human endogenous uveitis in clinical appearance. METHODS: Lewis rats were immunized with melanin-associated antigen and treated with intraperitoneal CsA for one week and then received the second immunization with the same antigen at 8 weeks after primary immunization. The treatment of CsA started either from the day of primary immunization (early treatment group) or from 14 days after the immunization (delayed treatment group). The clinical and histologic grading of the uveitis was assessed in comparison with the control group. RESULTS: In early treatment group, intraocular inflammation developed later than in control group. However the inflammation continued for a longer period. In delayed treatment group, the total period of intraocular inflammation was also increased even though CsA suppressed intraocular inflammation during the treatment period. The recurrence rate of experimental autoimmune anterior uveitis was similar in all groups. CONCLUSIONS: CsA suppressed intraocular inflammation significantly during the treatment period, howerever it did not seem to suppress the recurrence of the experimental uveitis.
Animals ; Cyclosporine* ; Humans ; Immunization ; Inflammation ; Rats ; Recurrence* ; Uveitis ; Uveitis, Anterior*

OBJECTIVE: Acute anterior uveitis (AAU) is the most common extra-articular manifestation in patients with axial spondyloarthritis (axSpA). However, the relationship between AAU and radiographic progression in axSpA remains unclear. Hence, we investigated whether the presence of AAU is associated with radiographic structural damage in patients with axSpA. METHODS: Clinical and radiographic data were obtained from 253 patients with axSpA. Radiographic progression over 2 years was assessed using the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS). Progression was defined as mSASSS worsening by ≥two units. Using propensity score (PS) matching, differences between patients with and without AAU were analyzed. RESULTS: The proportion of progressors among patients with AAU was lower than that of patients without AAU (13.6% vs. 29.5%, p=0.058). The rate of increase in mSASSS and number of syndesmophytes were lower in patients with AAU than patients without AAU (0.57±1.37 vs. 1.02±1.79, p=0.085 and 0.46±1.45 vs. 0.83±1.62, p=0.158). In multivariate regression analysis, presence of AAU was independently associated with slowed radiographic progression (odds ratio [95% confidence interval] 0.21 [0.07, 0.67], p=0.004). CONCLUSION: PS-matched axSpA patients with AAU showed significantly less radiographic progression than those without AAU.
Humans ; Propensity Score ; Spine ; Spondylitis, Ankylosing ; Uveitis ; Uveitis, Anterior

No abstract available.
Breast Neoplasms* ; Breast* ; Infusions, Intravenous* ; Uveitis, Anterior*

PURPOSE: The aim of this study is to determine the soluble Fas (sFas) levels in both sera and aqueous humor in patients with uveitis and compare them to the uveitis severity. METHODS: We measured the sFas levels in both sera and aqueous humor (AH) of patients (n=40) with uveitis and non-uveitis controls (n=27). The patients with uveitis comprised 24 Behcet's disease, 6 panuveitis, 5 anterior uveitis, 2 lens induced uveitis, 1 Vogt-Koyanagi-Harada-disease, 1 sarcoidosis, and 1 retinal vasculitis. The severity of uveitis was determined by the Hogan's grading method (0~4 grade) at the time of sampling. RESULTS:The concentration of aqueous sFas in uveitis patients was significantly higher than that in nonuveitis controls, while there was no difference in the serum concentration of sFas between the two groups. In the paired samples of serum and AH, obtained simultaneously, the aqueous sFas levels were higher than serum Fas levels in patients with uveitis, whereas the non-uveitis controls displayed significantly lower sFas levels in AH than in the serum. The sFas levels in AH or serum were not different between Behcet's uveitis and non-Behcet's uveitis. However, in patients with Behcet's uveitis, circulating sFas strongly correlated with aqueous sFas, which was not so in those with non-Behcet's uveitis. Patients (n=29) with more active (grade> or =2) uveitis had significantly higher levels of aqueous sFas than those (n=11) with less active (grade<2) uveitis. After treatment with steroid and/or immunosuppressive agents, aqueous sFas levels were decreased in parallel with a reduction in the number of inflammatory cells in the anterior chamber. CONCLUSIONS: The levels of sFas were elevated in patients with uveitis and correlated well with uveitis severity.
Anterior Chamber ; Aqueous Humor ; Humans ; Immunosuppressive Agents ; Panuveitis ; Retinal Vasculitis ; Sarcoidosis ; Uveitis* ; Uveitis, Anterior

PURPOSE: Despite ocular immune privilege, noninfectious chronic uveitis is relatively common. To investigate spontaneous turning on and off of noninfectious chronic uveitis, we examined the nature and apoptosis of infiltrating inflammatory cells from the anterior chamber of patients with chronic uveitis. METHODS: Aqueous humors were obtained with consent from patients with chronic recurrent uveitis at the time of active intraocular inflammation. Apoptosis of the infiltrating cells in aqueous humor was analyzed by flow cytometry, using fluorescence-labeled anti-CD95 antibody, anti-CD95L antibody, and Annexin V. RESULTS: Of total 35 patients recruited, 19 patients had anterior uveitis, 4 patients had intermediate uveitis, and 12 patients had panuveitis. The proportions of Fas+cell and FasL+ cell were over 90% independent of clinical characteristics of uveitis. Annexin V+ cells occupied 31.3% of all cells in aqueous humor. CONCLUSION: The high proportions of CD95+ cell, CD95L+ cell, Annexin+ cell suggest that there is an active apoptosis of inflammatory cells in anterior chamber of noninfectious chronic uveitis.
Annexin A5 ; Anterior Chamber* ; Apoptosis ; Aqueous Humor ; Flow Cytometry ; Humans ; Inflammation ; Panuveitis ; Uveitis* ; Uveitis, Anterior ; Uveitis, Intermediate

PURPOSE: Retisert(TM) (fluocinolone acetonide implant) has recently been approved for clinical use in patients with noninfectious posterior uveitis. We report a patient with intractable chronic Behcet's panuveitis who underwent Retisert(TM) implantation and showed a favorable outcome. METHODS: A 30-year-old male affected with intractable Behcet's uveitis of both eyes for over one year which did not respond to oral steroids and immunosuppressants; subcutaneous interferon injection caused undesirable side effects such as impotency and pyrexia. Initial visual acuities were 20/1000 in the right eye and 20/100 in the left eye, and both eyes showed severe panuveitis with posterior subcapsular cataract, especially in the right eye. The subtenon triamcinolone injection was performed in the right eye, which was only effective to anterior uveitis, and Retisert(TM) was implanted in the right eye after the cataract operation. Two months later the visual acuity increased to 20/25, and the inflammation was totally controlled. There were no ocular or systemic adverse events. CONCLUSIONS: Retiserttrade mark is a fast, effective, and safe treatment for chronic, non.infectious posterior uveitis.
Adult ; Cataract ; Eye ; Fever ; Fluocinolone Acetonide ; Humans ; Inflammation ; Interferons ; Male ; Panuveitis ; Steroids ; Triamcinolone ; Uveitis ; Uveitis, Anterior ; Uveitis, Posterior ; Visual Acuity

Uveitis is a comprehensive term that indicates the inflammation of not only the uvea but also its adjacent tissues, and its etiology, clinical feature and prognosis are various. Uveitis can be classified in a variety of ways and this fact makes it difficult to compare each result. So we classified uveitis by the location with the method of Henderly, D.E.(1986): ant-, post-, intermediate- and panuveitis. We determined the frequency of occurrence, etiology and clinical characteristics of various forms of uveitis in Korea. We conducted a retrospective analysis of 683 patIents with uveitis seen at Seoul National University Hospital from January 1978 to December 1987 and the results were as follows. 1. 192 cases(29.1%) occurred as anterior uveitis, 218 cases(31.9%) as posterior uveitis, 166 cases(24.3%) as panuveitis and 107 cases(15.7%) as pars planitis: Posterior uveitis was the most common form of uveitis. 2. In cases of anterior uveitis, 142 cases(70.4%) were idiopathic, traumatic uveitis was seen in 18 cases(9.4%). In posterior uveatis, III cases(50.9%) were idiopathic, retinal vasculitis including Eales' disease in 60 cases(27.5%) and toxo-plasmosis in 23 cases(10.6%). In cases of panuveitis, idiopathic form occurred in 80 cases(48.2%), Behcet's disease in 41 cases(24.7%): Idiopathic form was the most common entity in all locations of uveitis.
Classification ; Humans ; Incidence ; Inflammation ; Korea* ; Panuveitis ; Pars Planitis ; Prognosis ; Retinal Vasculitis ; Retrospective Studies ; Seoul ; Uvea ; Uveitis* ; Uveitis, Anterior ; Uveitis, Posterior

To evaluate effects of the topical administration of non-steroidal antiinflammatory drug on anterior uveitis, suprofen eye drop was instilled into the left eye of 10 pigmented rabbits and then experimental anterior uveitis was induced by injecting 750 mocro gram/kg endotoxin of Shigella flexneri serotype 1A into their peritoneal cavities. The pupillary diameters were measured, and cell and flare gradings were recorded in 20 eyes of 10 rabbits for one week at an interval of 12 hours for the first day and then daily. Differences between the treatment and control groups were investigated. All the above parameters showed greatest changes at 12 or 24 hours after the injection of endotoxin and became normal by one week. The treatment and the control groups demonstrated statistically significant difference at 12 hours, day 1, and day 2 as for pupillary diameter and at day 1 and day 2 as for cell and at 12 hours and day 1 as for flare. Thus, it is concluded that prostaglandin plays a role in miosis and the appearance of inflammatory cells and flare in anterior uveitis and the topical administration of non-steroidal anti-inflammatory drug can alleviate signs of anterior uveitis. The specific relationship between leucotriene B4 and polymorphonuclear leucocytes influx was not demonstrated.
Administration, Topical ; Miosis ; Rabbits ; Shigella flexneri ; Suprofen ; Uveitis, Anterior*

Endogenous uveitis is characterized by frequent remissions and exacerbations which lead to visual loss, and treated with immunosuppresive agents. We evaluated the therapeutic effect and complicantions of 15 patients (25 eyes) with endogenous uveitis who were treated with cyclosporin (Implanta). The inflammatory activities of anterior chamber and vitreous were reduced significantly after 1, 3, and 8 month follow-up of cyclosporin therapy, and the visual acuity was improved or sustaind in 52% of all patients. If cyclosporin therapy is intolerable, combining the cyclosporin with low dose of a steroid should be considered.
Anterior Chamber ; Cyclosporine* ; Follow-Up Studies ; Humans ; Uveitis* ; Visual Acuity