Objective To learn the depression levels of coronary restenosis patients after stent placement, so as to provide corresponding nursing strategies for them.Methods A total of 71 coronary restenosis cases after stent placement hospitalized in cardiovascular surgery department of our hospital were selected from 2004 to 2007.They were investigated by self-rating depression scale (SDS) .Among all cases,59 cases had different degrees of depression and were divided into test and control group randomly.29 cases in control group were given routine nursing care.Another 30 cases in test group were provided comprehensive nursing intervention.Rescoring with SDS of both group cases were compared with each other 10 days (preoperation) after nursing intervention.Results After 10 days (pre-operation) intervention, the scorings of test group were remarkably lower than those of either control group or before nursing intervention.There were statistical significant differences between them(P＜0.05).Clinical symptoms relieved in test group cases, which was better than that of control group.Conclusions Coronary restenosis cases after stent placement have higher incidence of depression feeling.We should pay attention to them and take corresponding comprehensive nursing intervention to relieve their depression, which is good for the preparation of their operation.