Introduction: According to the World Health Organization, 251 vaccines against coronavirus infection are under development. Although vaccination has been introduced nationwide to prevent coronavirus infection, vaccine activity varies (50-95%), and the risk of infection and complications may vary depending on the individual’s physical condition and immune activity. In addition, due to the prevalence of variant of concern, which reduces the activity of some vaccines and increases the risk of complications and mortality of COVID-19, each country and region needs to improve the knowledge and attitudes of citizens about the vaccine. there is a need to study. Goal: To study the knowledge and attitudes of people who have been vaccinated against COVID-19 among the target population of Uvs province. Materials and methods: The study was conducted using a descriptive method of observational research. Quantitative and qualitative methods were used to collect the survey data, and the data were collected in April 2021 through a questionnaire. A random sample of 4,212 people from 11 organizations involved in the Covid-19 vaccine was randomly selected from 24 organizations, and a total of 264 people were surveyed using 12 types of Covid-19 vaccine and analyzed using SPSS software. Result: According to the results of the survey, 4212 people from 11 organizations and 24 people from each organization were randomly selected from a total of 264 people. Mostly female participants (57.5%) have been included in this study. 67.4% of the respondents reported that they do not feel fear associated with vaccination and it means that most of the participants did not show any signs of panic. 91.2% participants did not have any symptoms after the vaccination. 30.4% from total participants was used anti-inflammatory or pain relief pills after vaccination at home. 45.8% of the respondents self reported that they have moderate knowledge about Covid-19 vaccine. Conclusion Overall knowledge of people from Uvs province was insufficient. However, attitude was good enough.