Primary neuroendocrine carcinoma of the breast is an extremely rare neoplasm that differs from other types of breast carcinoma according to the pathological features. We describe here a case of primary neuroendocrine carcinoma in a 72-year-old woman who complainted of a lump in her left breast. After examination and evaluation, the diagnosis was made by a core needle biopsy and the subsequent immunohistochemical examination of the specimen revealed more detailed information. We performed modified radical mastectomy, which showed no axillary node involvement. The patient was given neither radiation nor chemotherapy, however, but hormonotherapy was started postoperatively. Any recurrence has not been demonstrated at 12 months after the operation.
Aged ; Biopsy, Large-Core Needle ; Breast ; Breast Neoplasms ; Carcinoma, Neuroendocrine ; Female ; Humans ; Mastectomy, Modified Radical ; Recurrence

Primary neuroendocrine carcinoma of the breast is an extremely rare neoplasm that differs from other types of breast carcinoma according to the pathological features. We describe here a case of primary neuroendocrine carcinoma in a 72-year-old woman who complainted of a lump in her left breast. After examination and evaluation, the diagnosis was made by a core needle biopsy and the subsequent immunohistochemical examination of the specimen revealed more detailed information. We performed modified radical mastectomy, which showed no axillary node involvement. The patient was given neither radiation nor chemotherapy, however, but hormonotherapy was started postoperatively. Any recurrence has not been demonstrated at 12 months after the operation.
Aged ; Biopsy, Large-Core Needle ; Breast ; Breast Neoplasms ; Carcinoma, Neuroendocrine ; Female ; Humans ; Mastectomy, Modified Radical ; Recurrence

Purpose: The aim of this study is to examine the effectiveness of the neutrophil-lymphocyte ratio (NLR) and CRP/albumin ratio (CAR) in evaluating disease severity and predicting clinical outcomes in patients diagnosed with acute cholecystitis (AC). Methods: A total of 186 patients with AC were evaluated retrospectively. NLR, CAR, Mannheim Peritonitis Index (MPI), and P-POSSUM (Portsmouth Physiological and Operative Severity Score for the enUmeration of Mortality and Morbidity) scores were compared with AC severity grade. Results: The rates of the grade 1 patients (group 1) and the grade 2–3 patients (group 2) were 57.5% (n = 107) and 42.5% (n = 79) according to the disease severity according to Tokyo Guidelines criteria (TG) 18/TG13, respectively. The morbidity rates determined in groups 1 and 2 were 26.7% (n = 28) and 51.9% (n = 41), respectively. No mortality was found in group 1, whereas the mortality rate in group 2 was 6.3% (n = 5). According to multivariate analysis, CAR (odds ratio [OR], 1.234; P < 0.001) and MPI (OR, 1.175; P = 0.001) were found to be associated with moderate-severe disease while CAR (OR, 1.109; P = 0.035) and P-POSSUM morbidity (OR, 1.063; P = 0.007) variables were found to be associated with the presence of morbidity. Conclusion We have demonstrated that CAR can be used in predicting severity of AC and that CAR is an alternative simple parameter of P-POSSUM morbidity score in prediction of morbidity in these cases. In addition to other assessment methods, these scores can provide valuable and complementary information in assessment of disease severity and prognosis in AC.

This paper reports a presumptive severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) infection in a cat. A cat with respiratory disease living with three individuals with coronavirus disease 2019 showed bilateral ground-glass opacities in the lung on X-ray and computed tomography. The clinical swabs were negative for SARS-CoV-2 RNA, but the serum was positive for SARS-CoV-2 antibodies. Interstitial pneumonia and prominent type 2 pneumocyte hyperplasia were noted on histopathology. Respiratory tissues were negative for SARS-CoV-2 RNA or antigen, but the cat was positive for feline parvovirus DNA. In conclusion, the respiratory disease and associated pathology in this cat could have been due to exposure to SARS-CoV-2.