1.A Case of Uterine Cervical Cancer Presenting with Granulocytosis.
Heui June AHN ; Yeon Hee PARK ; Yoon Hwan CHANG ; Sun Hoo PARK ; Min Suk KIM ; Baek Yeol RYOO ; Sung Hyun YANG
The Korean Journal of Internal Medicine 2005;20(3):247-250
Granulocytosis occurs in 40% of patients with lung and gastrointestinal cancers, 20% of patients with breast cancer, 30% of patients with brain tumor and ovarian cancer and 10% of patients with renal cell carcinoma. Granulocytosis occurs because of production of G-CSF, GM-CSF and IL-6. Uterine cervical carcinoma with granulocytosis as a paraneoplastic syndrome, however, has been rarely reported. We recently witnessed a case of invasive squamous cell carcinoma of the uterine cervix with granulocytosis. Leukocytosis developed up to 69, 000/micro L, and then normalized after chemo-radiotherapy. There was no evidence of infection, tumor necrosis, glucocorticoid administration, or myeloproliferative disease by examination of a bone marrow aspirate when granulocytosis appeared. This phenomenon was probably associated with the secretion of hematopoietic growth factors such as G-CSF, GM-CSF and IL-6 by the tumor. We suggest that, like some other solid tumors, cervical cancer can present with granulocytosis as a paraneoplastic syndrome.
Uterine Neoplasms/complications/*diagnosis
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Uterine Cervical Neoplasms/complications/*diagnosis/physiopathology
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Paraneoplastic Syndromes/*etiology
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Middle Aged
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Leukocytosis/*etiology
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Humans
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Granulocytes/*pathology
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Female