The study had been conducted in 85 patients aged from 22-49, who were diagnosed as cervical erosion to find out the effect of cryosurgery method. Results: this method was effective in treating cervical erosion; 80% of the patients recovered after the 1st time treatment and 20% in the 2 nd times. The percentage of the recovery related to diameter injuries. This method did not cause any serious complications but some light complications such as disordered menstruation (17.6%), menorrhagia (11.8%), backache or lower backache (5.9%), appendage inflammation (4.7%). After the treatment, 8.2% of these cases are able to get pregnant and give birth as common
Uterine Cervical Erosion, Cryosurgery, Therapeutics

OBJECTIVETo investigate the effects of focused ultrasound (FUS) treatment on cervical microenvironment in infertility women with chronic cervicitis.

METHODSA total of 10 women treated in Infertility Clinic of Obstetrics and Gynecology Hospital of College of Medicine of Zhejiang University were assessed. The women aged from 25 to 34 with normal menstrual cycles had moderate or severe cervical erosion. Ultrasound showed they had normal ovulation. The sperms of their husbands had normal motility and number. The FUS they received had a focal depth range of 4 - 6 mm, a resonant frequency of 9 - 11 MHz, and an output power of 3.5 W. The follow-up time was three months. The changes of cervical mucus and the results of postcoital test were evaluated. The clinical effects on cervical erosion and complications were also evaluated.

RESULTIn 6 cases of severe cervical erosion, 2 were cured, 2 were improved significantly (more than 50 % reduction of erosion area) and 2 were improved (less than 50 % reduction of erosion area). In 4 cases of moderate cervical erosion, 2 were cured, 2 were improved significantly. After the treatment, the median of cervical mucus score during LH peak were increased from 11 to 13 (Wilcoxon test, P=0.014). Postcoital test showed that the median of highly motile sperm (grade III and grade II) of 5 high-power field were increased from 22 to 52 (Wilcoxon test, P=0.015). Mild side effects without medical intervention included vaginal fluid in all 10 women, vaginal spotting in 2 women. No serious side effects were observed.

CONCLUSIONThe focused ultrasound therapy can help to improve the cervical microenvironment for infertility women with moderate or severe cervical erosion without serious side effects.

Adult ; Chronic Disease ; Female ; Humans ; Infertility, Female ; therapy ; Male ; Treatment Outcome ; Ultrasonic Therapy ; methods ; Uterine Cervical Erosion ; therapy ; Uterine Cervicitis ; therapy

Administration, Intravaginal ; Adult ; Combined Modality Therapy ; Drugs, Chinese Herbal ; administration & dosage ; Female ; Humans ; Microwaves ; therapeutic use ; Middle Aged ; Phytotherapy ; Uterine Cervical Erosion ; therapy

OBJECTIVETo observe the effect of recombinant human epithelial growth factor (rhEGF) in promoting the healing of cervical erosion.

METHODSForty-eight patients with cervical erosion were treated with rhEGF and 30 with 500 kHz high-frequency electromagnetic wave, and the effects of the therapies were compared in terms of healing of the cervical wound, healing time, volume of vaginal discharge and bleeding and the lasting time.

RESULTSIn comparison with radiofrequency therapy, the healing of the lesion took significantly shorter time with rhEGF therapy, which also resulted in less vaginal discharge that lasted for shorter time without causing vaginal bleeding.

CONCLUSIONrhEGF can obviously accelerate the healing of cervical erosion.

Adult ; Electromagnetic Phenomena ; Epidermal Growth Factor ; genetics ; therapeutic use ; Female ; Humans ; Middle Aged ; Recombinant Proteins ; therapeutic use ; Treatment Outcome ; Uterine Cervical Erosion ; drug therapy ; pathology ; therapy ; Wound Healing ; drug effects

OBJECTIVETo study the clinicopathologic features and differential diagnosis of lymphoma-like lesions and lymphoma of uterine cervix.

METHODSClinical data and hematoxylin and eosin-stained slides of 10 cases of lymphoma-like lesion and 16 cases of lymphoma of uterine cervix were reviewed. Immunohistochemical study for B- and T-cell markers and light chains (kappa, lambda) were performed on paraffin sections. The rearrangement status of immunoglobulin heavy chain (IgH) gene was analyzed with semi-nested polymerase chain reaction in 4 cases lymphoma-like lesion and 4 cases of lymphoma of uterine cervix.

RESULTSThe age of patients with lymphoma-like lesion ranged from 24 to 54 years (medium = 43 years). The lesion generally presented with cervical erosion or polyp. Microscopically, it is characterized by focal or diffuse superficial infiltration of immunoblast-like large B cells intermingled with a polymorphic population of inflammatory cells, including plasma cells, eosinophils and neutrophils. Maturation of the transformed large B cells was also noticed. On the other hand, the age of the patients with lymphoma of uterine cervix varied from 28 to 78 years (medium = 58 years). Cervical mass or diffuse enlargement of cervix were the commonest clinical findings. The cases included 12 examples of diffuse large B-cell lymphoma and 4 examples of follicular lymphoma. The former was characterized by a diffuse monomorphic population of large atypical lymphoid cells, while neoplastic follicles were identified in the latter. Neither polymorphic inflammatory infiltrates nor maturation phenomenon was found. The immunostaining for kappa and lambda light chains was inconclusive. Molecular study showed clonal rearrangement of IgH gene in all cases of cervical lymphoma, as well as 2 cases of lymphoma-like lesion.

CONCLUSIONSThe distinction between lymphoma-like lesion and lymphoma of uterine cervix depends primarily on the clinical and histopathologic features. Assay for rearrangement of IgH gene may be helpful in differential diagnosis, though monoclonality can be detected in some benign lesions as well.

Adult ; Aged ; Antigens, CD20 ; metabolism ; CD79 Antigens ; metabolism ; Diagnosis, Differential ; Female ; Gene Rearrangement, B-Lymphocyte, Light Chain ; Humans ; Immunoglobulin G ; genetics ; Lymphoma, Follicular ; genetics ; metabolism ; pathology ; Lymphoma, Large B-Cell, Diffuse ; genetics ; metabolism ; pathology ; Middle Aged ; Polyps ; genetics ; metabolism ; pathology ; Uterine Cervical Erosion ; genetics ; metabolism ; pathology ; Uterine Cervical Neoplasms ; genetics ; metabolism ; pathology ; Young Adult