1.A Case of Primary Pure Cholesterol Hepatolithiasis.
Chul Ho HYUNG ; Myung Hwan KIM ; Gi Deog KIM ; Sung Hee PYO ; Sung Hoon MOON ; Hyeong Su KIM ; Young Ju JUNG ; Moon Hee SONG ; Sang Soo LEE ; Dong Wan SEO ; Sung Koo LEE ; Young Il MIN
Korean Journal of Gastrointestinal Endoscopy 2003;26(6):448-453
In the past, most hepatolithiasis had been brown pigment stones in Korea. However, stones with high cholesterol content are found with increasing frequency. Abdominal ultrasonography is superior to CT for detection of cholesterol hepatolithiasis. The characteristic gross morphology of pure cholesterol hepatolithiasis shown by cholangioscopy is diagnostic. An effective medical management consists of stone removal by percutaneous transhepatic cholangioscopy and ursodeoxycholic acid for the prevention of recurrence. We here report a case of primary pure cholesterol hepatolithiasis with a review of the literature. A 29-year-old woman presented with right upper quadrant pain. Abdominal ultrasonography showed right intrahepatic duct stones. A cholangioscopy revealed typical cholesterol stones, mucosal hyperemia, and mild narrowing in stone-bearing intrahepatic duct. Cholangioscopic stone removal via the percutaneous transhepatic route was successfully performed. To prevent recurrence, ursodeoxycholic acid was administered.
Adult
;
Cholesterol*
;
Female
;
Humans
;
Hyperemia
;
Korea
;
Recurrence
;
Ultrasonography
;
Ursodeoxycholic Acid
4.Management of Gallstone.
The Korean Journal of Gastroenterology 2018;71(5):253-259
Gallstones are one of the most common diseases worldwide. Recently, the incidence of gallstones has increased and the pattern of gallstones has changed in Korea. Laparoscopic cholecystectomy is the standard treatment for symptomatic gallstones. Expectant management is considered the most appropriate choice in patients with asymptomatic gallstones. The dissolution of cholesterol gallstones by oral bile acid, such as ursodeoxycholic acid, can be considered in selected patients with gallstones. Although the advent of laparoscopic cholecystectomy has moved interest away from the pharmacologic treatment of gallstones, several promising agents related to various mechanisms are under investigation.
Bile
;
Cholecystectomy, Laparoscopic
;
Cholesterol
;
Gallstones*
;
Humans
;
Incidence
;
Korea
;
Ursodeoxycholic Acid
5.Chemical constituents and pharmacological action of bile acids from animal:a review.
Xing-Ling CHEN ; Shu-Lan SU ; Rui LIU ; Da-Wei QIAN ; Li-Ling CHEN ; Li-Ping QIU ; Jin-Ao DUAN
China Journal of Chinese Materia Medica 2021;46(19):4898-4906
Bile of animal(mainly chicken, pig, snake, cow, and bear) has long been used as medicine. As the major active components of bile, bile acids mainly include cholic acid, deoxycholic acid, chenodeoxycholic acid, ursodeoxycholic acid, and taurochenodeoxycholic acid. They interact with intestinal microorganisms in enterohepatic circulation, thereby playing an important part in nutrient absorption and allocation, metabolism regulation, and dynamic balance. Bile acids have pharmacological effects such as protecting liver, kidney, heart, brain, and nerves, promoting bile secretion, dissolving gallstones, anti-cancer, relieving cough and dyspnea, dispelling phlegm, treating eye diseases, and regulating intestinal function and blood glucose, which are widely used in clinical practice. This study summarized and analyzed the research on the chemical constituents and pharmacological effects of bile acids from medicinal animals, in a bid to provide scientific basis and reference for the further development and utilization of bile acids.
Animals
;
Bile Acids and Salts
;
Cattle
;
Chenodeoxycholic Acid
;
Cholic Acids
;
Deoxycholic Acid
;
Female
;
Swine
;
Ursodeoxycholic Acid
6.Synthetic Bile Acid Derivative HS-1200-induced Apoptosis of Human Osteosarcoma Cells.
Gyoo Cheon KIM ; Young Soo HER ; Jae Hyun PARK ; Yong Suk MOON ; Young Hyun YOO ; Sang Hun SHIN ; Bong Soo PARK
Korean Journal of Anatomy 2004;37(5):449-457
Bile acids and synthetic its derivatives induced apoptosis in various kinds of cancer cells and had anticancer effects. However, it wasn`t discovered those materials have apoptosis induced effects on osteosarcoma cells. The present study was done to examine the synthetic bile acid derivatives induced apoptosis on osteosarcoma cells and such these apoptosis events. The synthetic bile acid derivatives, chenodeoxycholic acid (CDCA) induced the cell death on human osteosarcoma (HOS) cells contrary to ursodeoxycholic acid (UDCA). HS-1200, a synthetic derivative of CDCAs, was chosen to experiment apoptosis events in HOS cells. HOS cells treated with HS-1200 showed nucleus condensation, cytochrom c release, Bax/Bcl-xL alteration, activation of caspase-3 and caspase-activated deoxyribonuclease (CAD), and degradation of poly (ADP-ribose) polymerase (PARP). Though this study needs more investigations, these in vitro data suggest that treatment of the synthetic bile acid derivatives can give medical therapy on HOS cells.
Apoptosis*
;
Bile Acids and Salts
;
Bile*
;
Caspase 3
;
Cell Death
;
Chenodeoxycholic Acid
;
Humans*
;
Osteosarcoma*
;
Ursodeoxycholic Acid
7.Clinical analysis of intrahepatic cholestasis of pregnancy.
Lei LI ; Xin-Yan ZHAO ; Xiao-Juan OU ; Ji-Dong JIA
Chinese Journal of Hepatology 2013;21(4):295-298
OBJECTIVETo generate a comprehensive clinical profile of intrahepatic cholestasis of pregnancy (ICP) by systematically reviewing ICP cases managed in our hospital.
METHODSThe recorded clinical data, including diagnosis, complications, management, and maternal and infant outcomes, of nine ICP cases were collected retrospectively and reviewed systematically.
RESULTSSeven of the nine total ICP patients presented with pruritus. All nine of the ICP patients showed bile acid level beyond the normal range. ICP complications included gestational hypertension (n = 3), diabetes mellitus (DM, n = 1) and impaired glucose tolerance (IGT, n = 1), and pre-eclampsia (n = 1). The infant of one patient with severe ICP showed meconium-stained liquor. All nine of the ICP patients underwent surgical delivery, of which three were delivered preterm (between the 35th and 36th week of gestation). All mothers' total bile acids declined to normal levels after delivery, and all infants survived without complication.
CONCLUSIONICP does not increase the puerpera mortality rate and does not represent a poor prognosis for infants. Bile acid levels in the ICP patients, however, may be related to the extent of premature delivery time. While the standard drug treatment of ursodeoxycholic acid is suitable for most ICP cases, those with insufficient gestational age may benefit from adjuvant corticosteroid therapy to promote fetal lung maturation prior to preterm delivery. Severe ICP cases should be managed by inducing artificial labor or performing Caesarean section.
Bile Acids and Salts ; Female ; Humans ; Pregnancy ; Pregnancy Outcome ; Pruritus ; Retrospective Studies ; Ursodeoxycholic Acid ; therapeutic use
9.Effects of ursodeoxycholic acid on intrahepatic cholestasis in rats.
Lanjuan LI ; Xiaowei XU ; Fangfang LU ; Nianfeng ZHAO
Chinese Medical Journal 2003;116(7):1099-1103
OBJECTIVETo investigate the effects of treatment with ursodeoxycholic acid (UDCA) on intrahepatic cholestasis in rats, and to explore its mechanism.
METHODRats suffering from intrahepatic cholestasis were treated with UDCA. Their serum alanine transaminase (ALT), alkaline phosphatase (ALP), total bilirubin (TBIL), direct bilirubin (DBIL), gamma-glutamyl transpeptidase (gamma-GT), total cholesterol (TCH), bile flow, total bile acid excretion, total Na(+) and TCH of bile were measured before and after treatment. In addition, the changes of liver tissue under microscrope were observed and recorded.
RESULTSCompared with the control group, serum ALT, ALP, TBIL, DBIL, gamma-GT and TCH of rats in the treatment group decreased, while bile flow, total bile acid excretion, total Na(+) and TCH decreased significantly. Degeneration of hepatocytes, infiltration of inflamed cells and proliferation of small bile ducts in the treatment group were improved under microscope.
CONCLUSIONUDCA may have therapeutic effects on cholestatic hepatitis. The mechanism may involve in its hydrophilicity, choleretic effect and immune modulation.
Animals ; Cholestasis, Intrahepatic ; drug therapy ; Male ; Rats ; Rats, Sprague-Dawley ; Ursodeoxycholic Acid ; therapeutic use
10.Presentation of Progressive Familial Intrahepatic Cholestasis Type 3 Mimicking Wilson Disease: Molecular Genetic Diagnosis and Response to Treatment.
Salih BOGA ; Dhanpat JAIN ; Michael L SCHILSKY
Pediatric Gastroenterology, Hepatology & Nutrition 2015;18(3):202-208
Progressive familial intrahepatic cholestasis type 3 (PFIC3) is an autosomal recessive disorder of cholestasis of hepatocellular origin, typically seen in infancy or childhood caused by a defect in the ABCB4 located on chromosome 7. Here we report on an older patient, aged 15, who presented with biochemical testing that led to an initial consideration of a diagnosis of Wilson disease (WD) resulting in a delayed diagnosis of PFIC3. Diagnosis of PFIC3 was later confirmed by molecular studies that identified novel mutations in the ABCB4 gene. Cholestasis due to PFIC3 can cause elevated hepatic copper and increased urine copper excretion that overlap with current diagnostic criteria for WD. Molecular diagnostics are very useful for establishing the diagnosis of PFIC3. Ursodeoxycholic acid ameliorates cholestasis in PFIC3, and may help mediate a reduction in hepatic copper content in response to treatment.
Cholestasis
;
Cholestasis, Intrahepatic*
;
Chromosomes, Human, Pair 7
;
Copper
;
Delayed Diagnosis
;
Diagnosis*
;
Hepatolenticular Degeneration*
;
Humans
;
Molecular Biology*
;
Pathology, Molecular
;
Ursodeoxycholic Acid