BACKGROUND: Blood cultures (BC ) are commonly ordered during the initial assessment of patients with community-acquired pneumonia (CAP), yet their yield remains low. Selective use of BC would allow the opportunity to save healthcare resources and avoid patient discomfort. The study was to determine what demographic and clinical factors predict a greater likelihood of a positive blood culture result in patients diagnosed with CAP. METHODS: A structured retrospective systematic chart audit was performed to compare relevant demographic and clinical details of patients admitted with CAP, in whom blood culture results were positive, with those of age, sex, and date-matched control patients in whom blood culture results were negative. RESULTS: On univariate analysis, eight variables were associated with a positive BC result. After logistic regression analysis, however, the only variables statistically significantly associated with a positive BC were WBC less than 4.5 x 109/L [likelihood ratio (LR): 7.75, 95％ CI=2.89-30.39], creatinine >106 μmol/L (LR: 3.15, 95％CI=1.71-5.80), serum glucose<6.1 mmol/L (LR: 2.46, 95％CI=1.14-5.32), and temperature > 38 °C (LR: 2.25, 95％ CI =1.21-4.20). A patient with all of these variables had a LR of having a positive BC of 135.53 (95％ CI=25.28-726.8) compared to patients with none of these variables. CONCLUSIONS: Certain clinical variables in patients with CAP admitted to hospitals do appear to be associated with a higher probability of a positive yield of BC, with combinations of these variables increasing this likelihood. We have identified a subgroup of CAP patients in whom blood cultures are more likely to be useful.