Nephrogenic adenoma is a rare benign metaplastic proliferation of urothelium, which is associated with chronic irritation, infection or trauma. We report nephrogenic adenoma in the urinary bladder containing stone.
Adenoma* ; Urinary Bladder ; Urothelium

The recurrence of renal cell carcinoma (RCC) in the remnant urothelium is rare, and in this paper we report a case in which the condition recurred in the remnant ureter five years after radical nephrectomy. The recurrent mass was seen on retrograde ureterograms as polypoid filling defect, and on CT images as soft tissue mass-like density. In view of the radiologic and pathologic findings, we believe that in this case, the mechanism of intraureteral recurrence was direct implantation.
Carcinoma, Renal Cell* ; Nephrectomy* ; Recurrence* ; Ureter ; Ureteral Neoplasms ; Urothelium

Nephrogenic adenoma is a rare proliferative response of urothelium to chronic irritation or infection. It has been reported in the bladder, ureter, renal pelvis and urethra, but to date there have been only 15 reports, of its occurrence in the ureter. We present a further case of this lesion in this unusual location.
Adenoma* ; Kidney Pelvis ; Ureter* ; Urethra ; Urinary Bladder ; Urothelium

PURPOSE: CD10, a membrane-bound zinc-dependent metallopeptidase, is normally expressed in many tissues. Accordingly, the derangement of CD10 expression may be related to development or progression in a variety of tumors. The aim of this study is to examine any association between CD10 expression and clinicopathological parameters in bladder transitional cell carcinomas (TCCs) and the relationship between expression of E-cadherin and CD10. MATERIALS AND METHODS: Immunohistochemical staining was performed for CD10 and E-cadherin in tissues of 94 TCCs and 10 non-neoplastic bladder mucosa. RESULTS: Positive immunoreactivity for CD10 was observed in non-neoplastic urothelium at a proportion of 80% and TCCs were observed at a rate of 23%. A positive rate of CD10 expression was observed in 10% of total cases of a low grade tumor and in 35% of those of a high grade tumor. It was also observed in 15% of pTa tumors, 13% of pT1 tumors, and 48% of pT2 tumors. In addition, CD10 expression showed reciprocal correlation with expression of membranous E-cadherin in tumors. CONCLUSION: CD10 is again expressed at a certain stage during the neoplastic process of TCCs and could play some roles intheir carcinogenesis.
Cadherins ; Carcinoma, Transitional Cell ; Neprilysin ; Urinary Bladder ; Urothelium

Twenty seven consecutive male and female patients with trigonal cystitis are divided into 2 groups on the basis of the presence or absence of the pseudomembrane(nest of squamous epithelium). One group consists of 15 patients with squamous epithelium and the other of 12 patients with no squamous epithilium on the cystoscopic biopsies from the vesical trigone. The clinical symptoms, physicochemical study and bacteriologic culture of urine, cystoscopic changes and histologic findings are compared between the two groups. 1. Both squamous and non-squamous epithelial groups show no significant differences in the clinical and cystoscopic findings. 2. Pathologic changes of the urothelium and lamina propria of the trigonal mucosa are identical with one to the other group. 3. Trigonal cystits with squamous epithelium occurs most frequently in sexually active premenopausal women and less frequently in the female of post-menopause and even rarely in the male. No age and sex predilection are found in the patients with trigonal cystitis without squamous epithelium.
Biopsy ; Cystitis* ; Epithelium ; Female ; Humans ; Male ; Mucous Membrane ; Postmenopause ; Urothelium

Inverted papilloma of the urothelium is a rare, benign polypoid lesion which has typical histologic findings. Microscopically, a nonpapillary urothelium covers the surface from which cords of same epithelium invert and extend deep into the core in an anastomosing pattern, always maintaining its benign histological characteristic. Recently, we experienced a case of inverted papilloma of the bladder in 23-year-old male.
Epithelium ; Humans ; Male ; Papilloma, Inverted* ; Urinary Bladder* ; Urothelium ; Young Adult

Inverted papilloma of the urothelium is a rare, benign polypoid lesion which has typical histologic findings. Microscopically, a nonpapillary urothelium covers the surface from which cords of same epithelium invert and extend deep into the core in an anastomosing pattern, always maintaining its benign histological characteristic. Recently, we experienced a case of inverted papilloma of the bladder in 23-year-old male.
Epithelium ; Humans ; Male ; Papilloma, Inverted* ; Urinary Bladder* ; Urothelium ; Young Adult

Xanthogranulomatous cystitis is a rare benign chronic inflammatory disease. To the best of our knowledge, only 16 cases have been reported in the literature. The etiology of xanthogranulomatous cystitis may include immunological disorders, abnormal lipid metabolism, a reduction of chemotactic activities, and metaplasia of the urothelium due to a chronic infection. Only one case has been reported in the Korean literature. Here we describe two cases of xanthogranulomatous cystitis with a review of the previous reports.
Cystitis* ; Inflammation ; Lipid Metabolism ; Metaplasia ; Urinary Bladder ; Urothelium

Using specific monoclonal antibodies to the ras and HER-2/neu oncoprotein, a total of 8 normal urothelium and 58 transitional cell carcinoma(TCC) of the urinary bladder were stained immunohistochemically to investigate the possible roles of the oncogenes in the development of bladder TCC and their implications. Of the 52 bladder TCC specimens which contained the outer layer in the sections, 51 tumors showed the expression of the ras p21 in the outer layer. 56 of 58 bladder TCC specimens showed the expression of ras p21 in the intermediate and basal layers. The staining intensity in whole layers was relatively higher than that of the normal urothelium. The staining intensity in outer layer was not correlated with the tumor grade and invasiveness, while in intermediate and basal layers significantly correlated. HER-2/neu expression occurred in 22 (38%) of 58 TCC, whereas no normal urothelial cells were reactive for HER-2/neu. HER-2/neu expression rate was significantly correlated with the tumor grade and invasiveness. These findings suggest that ras and HER-2/neu oncogenes may play a crucial role in the development of bladder TCC and that immunohistochemical characteristics of these oncoproteins may give a additional prognostic information in the patients with bladder TCC.
Antibodies, Monoclonal ; Carcinoma, Transitional Cell* ; Humans ; Oncogene Proteins* ; Oncogenes ; Urinary Bladder* ; Urothelium

Mucinous cystadenocarcinoma (MC) of the kidney is a rare epithelial tumor originating from the renal pelvic urothelium and few study cases have been reported. Because of the rarity of these tumors and their unknown histogenesis, its diagnosis is difficult until surgical exploration. We report here on a 55-year-old man referred to the urology department from the hepatology department because of a cystic renal mass measuring approximately 5 cm in size, which was detected incidentally under ultrasonography during the routine examination of liver. The renal mass was finally diagnosed as MC originating from kidney after partial nephrectomy and the patient still showed no evidence of recurrence until 12 months postoperatively. This is the first report on a case of renal MC in a patient who underwent partial nephrectomy. The aim of this report is to present our unusual case of MC and also review the previous literature on the pathological and radiological aspects of MC of kidney.
Cystadenocarcinoma, Mucinous* ; Diagnosis ; Gastroenterology ; Humans ; Kidney* ; Liver ; Middle Aged ; Mucins* ; Nephrectomy* ; Recurrence ; Ultrasonography ; Urology ; Urothelium