OBJECTIVES: Diminished suppression of the P50 response, a consistent finding in schizophrenia, has also been reported in patients with bipolar disorder. It is a promising endophenotype for schizophrenia, but its relationship to genetic liability in mood disorder is controversial. The present study investigated event-related brain potential (ERP) indices of auditory processing and sensory gating in mood disorder and subgroups of patients with bipolar disorder with or without a history of psychosis using the P50 dual-click procedure. METHODS: The P50 auditory evoked potential response to paired stimuli was measured in 77 subjects with mood disorder (58 with bipolar disorder and 19 with major depressive disorder) and 28 healthy controls. P50 parameters were compared between groups. RESULTS: P50 suppression in patients with mood disorder did not differ from that in the healthy subjects. Except for S1 latency, there were no significant differences in P50 parameters between the diagnosis groups. In patients with bipolar disorder, a history of psychosis made no difference to P50 parameters. CONCLUSION: P50 was not significantly impaired in patients with mood disorder. There has been much debate on the meaning of P50, and more studies including longitudinal within-subjects studies are warranted to clarify the meaning and mechanisms of P50.
Bipolar Disorder ; Brain ; Endophenotypes ; Evoked Potentials, Auditory ; Humans ; Mood Disorders ; Psychotic Disorders ; Schizophrenia ; Sensory Gating

Premature separation of the placenta(abruptio placentae), as a serious obstetric complication, has been recognized to be associated with disseminated intravascular coagulation(DIC) in the newborn period. However, pathologic evidence for DIC generally has been lacking or rarely reported. Recently we have experienced one case of DIC in an infant born after abruptio placentae. The infant had suffered from cyanosis, dyspnea and convulsion. The peripheral blood smear of this infant revealed severe thrombocytopenia, but there was no evidence of external bleeding. At autopsy widespread hyaline thrombi were observed in the small vessels and capillaries of the brain and liver. The brain showed diffuse cortical and subcortical white matter necrosis associated with hemorrhage. Bilateral symmetrical necrosis of the thalamus was also seen. Massive fresh hemorrhage was present in the endometrium and myometrium. We considered tha tthe above findings were consistent with DIC. Pertinent literatures on neonatal DIC are also reviewed briefly.
Abruptio Placentae* ; Animals ; Autopsy ; Brain ; Capillaries ; Cyanosis ; Dacarbazine ; Disseminated Intravascular Coagulation* ; Dyspnea ; Endometrium ; Female ; Hemorrhage ; Humans ; Hyalin ; Infant* ; Infant, Newborn ; Liver ; Mice ; Myometrium ; Necrosis ; Pregnancy ; Seizures ; Thalamus ; Thrombocytopenia

This article presents the results of the Implementation Study of the Seoul Cancer Registry, which started in July, 1991 as a population based cancer registry in Seoul, Korea. The completeness and validity of the registered data were evaluated using Mortality/Incidence ratio (M/I ratio), Histologically Verified Cases (HV%), Primary Site Uncertain (PSU%), and Age Unknown (Age UNK%). Owing to the additional active surveillance, the completeness of the data turned out to be fairly acceptable, except for the aged over 75(Mortality/Incidence ratio was over 100%). Eventhough the Seoul cancer registry(SCR) has further way to go in the completeness especially among elderly persons, the validity of SCR data was also acceptable in terms of HV%, PSU%, and Age UNK%. However, PSU% and Age UNK% might need to be further reduced to be comparable with other well established cancer registries. The age standardized incidence rates(ASR) of all cancers between July 1, 1991 and June 30, 1992 were 232.4/100,000 in males and 147.9/100,000 in females. The top five major sites of cancers in Seoul were the stomach, liver, lung, colo-rectum, and bladder in order in males, and the uterine cervix, stomach, breast, colo-rectum, and liver in females. Those 5 cancer sites comprised 68.9% and 64.7% of the total cancer incidence in males and females, respectively.
Adolescent ; Adult ; Age Factors ; Aged ; Child ; Child, Preschool ; Female ; Human ; Incidence ; Infant ; Korea/epidemiology ; Male ; Middle Age ; Neoplasms/*epidemiology/pathology ; *Registries ; Sex Factors ; Support, Non-U.S. Gov't