Among 666 premature infants or low birthweight infants who were admitted in NICU of St. Francisco General Hospital from January 1990 to Jun 1992, 96 infants were diagnosed as retinopathy of prematurity by indirect ophthalmoscope. The result were follows: 1) Among 666 patients, retinopathy of prematurity developed in 96 patients(14.1%) 2) The high incidence was observed in low birthweight and small gestational age. 3) Mean age of first diagnosing time was 42.0( 12 day of life and mean gestational age was 31.8 2.5 weeks and mean birthweight was 1646.5 (350.7gm. 4) In gestational age, birthweight and duration of oxygen therapy, there was statistically difference between cryotherapy group and spontaneous regression group. Other possible risk factors-hyaline membrane disease, apnea, anemia-were showed higher incidence in cryotherapy group. 5) Among the 20 infants who were treated with cryotherapy, 16 infants (80%) showed regression of neovascularization.
Apnea ; Cryotherapy ; Gestational Age ; Hospitals, General ; Humans ; Incidence ; Infant ; Infant, Newborn ; Infant, Premature ; Membranes ; Ophthalmoscopes ; Oxygen ; Retinopathy of Prematurity*

Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder with a low platelet count characterized by premature platelet destruction and suppression of platelet production mediated by autoantibodies, which may predispose to bleeding. Although the prevalence of coronary artery disease (CAD) in ITP seems to be rare, their co-occurrence is not unusual. Patients with ITP have increased risks for thrombosis and atherosclerosis associated with hemostatic factors, endothelial damage, and the negative effects of steroid and immunoglobulin therapies. Thus, the coexistence of ITP and CAD presents complex problems requiring a balance between hemorrhagic risk and prevention of thrombosis. Here, the authors present two patients with ITP, who were revascularized in different ways for CAD. Although the optimal management of thrombocytopenic patients with CAD is uncertain, individualized treatment modalities can be useful in patients with ITP and CAD.
Atherosclerosis ; Autoantibodies ; Blood Platelets ; Coronary Artery Disease* ; Hemorrhage ; Humans ; Immunization, Passive ; Myocardial Revascularization ; Platelet Count ; Prevalence ; Purpura, Thrombocytopenic, Idiopathic* ; Thrombosis

BACKGROUND: The maximal removal rate of indocyanine green (ICG Rmax), which has been used as a useful indicator of quantitative assessment of the hepatic function, has some disadvantages such as high cost, requirement of multiple sampling, and long turn-around time. This study was designed to clarify that the measurement of the lidocaine metabolite, monoethylglycinekylidide (MEGX) test, can replace the ICG Rmax. And in healthy adults, MEGX forma pion was measured and compared according to methods of measurement and serf. METHOD: In 18 patients to whom ICG Rmax test was requested, ICG Rmax test was carried out at two doses of 0.5 mg/kg and 5 mg/kg and MEGX formation after 15 minute of 1 mg/kg lidocaine Injection was measured by fluorescence polarization immunoassay (FPIA) method. The correlation between them was analyzed, To 25 healthy volunteers included in this study as normal control, lidocaine was given intravenously at, a dose of 1 mg/kg and MEGX forma pion was measured IS and 30 minute later (MEGX15, MEGX30) using both high performance liquid chromatography (HPLC) and FPIA methods. RESULT: Patient group resealed significant correlation between ICG Rmax and MEGX15 (r=0.7674, p<0.001) and also between ICG Rl5 and MEGX15 (r=0.5612, p=0.008). There was significant difference between MEGX15 of 9 patients with chronic liver diseases and those of normal controls (22.24+/- 13.18 and 35.40+/- 14.43 ng/mL, respectively) (p=0.01). In normal controls, the correlation between methods was significant (p=0.001) and the values measured by FPIA method was significantly higher than that by HPLG (p(0.001). Of the normal controls, male group had higher MEGX15 values than female group in both methods (in HPLC method 33.89+/-15.95 and 22.53+/- 8.36, and in FPIA method 41.48+/-16.61 and 28.81+/-7.88 ng/mL, respectively), and in female group MEGX30 values was significantly elevated compared to MEGX15 (p<0.001). CONCLUSION: Inferred from the fact that the correlation between ICG Rmax and MEGX was good, MEGX test can be considered a replacement for ICG Rmax. In healthy adults, it is considered that there is serf-related difference In the rate of lidocaine metabolism so we should pay attention to it in interpreting the MEGX results.
Adult ; Chromatography, High Pressure Liquid ; Chromatography, Liquid ; Female ; Fluorescence Polarization Immunoassay ; Healthy Volunteers ; Humans ; Indocyanine Green* ; Lidocaine ; Liver Diseases ; Male ; Mesons ; Metabolism

A weanling Thoroughbred foal was admitted to Equine Hospital, Korea Racing Association with signs of colic. On admission the foal was sweating profusely, appeared anxious and exhibiting signs suggestive of abdominal pain. Clinical examination revealed: tachycardia (90 beats/min), tachypnea (50 breaths/min) and congested and slightly cyanotic mucous membranes. No intestinal sounds were auscultated in all 4 abdominal quadrants. Rectal palpation identified concurrent cecum and large colon impactions. Treatment consisted of intravenous administration of a balanced electrolyte solution, nasogastric siphonage and administration of analgesics. Nasogastric reflux contained ascarids. This treatment failed to alleviate the signs of colic. The foal died 3 hours later following discharge because the owner didn't want laparatomy because of economic constraints. Prior to admission this foal had not received any prophylactic anthelmintic treatment. In necropsy, there were masses of ascarids accumulation in the stomach, small intestine and large intestine. The outcome of this report is to describe the first diagnosed case of gastrointestinal impaction by P. equorum in a Thoroughbred foal in South Korea and indicates the importance of regular anthelmintic treatment.
Animals ; Ascaridida Infections/diagnosis/parasitology/*veterinary ; Ascaridoidea/*isolation&purification ; Fatal Outcome ; Fecal Impaction/diagnosis/parasitology/*veterinary ; Horse Diseases/diagnosis/*parasitology ; Horses ; Intestinal Diseases, Parasitic/diagnosis/parasitology/*veterinary ; Korea

Changes in heart rate during reversal of neuromuscular block have been a subject of clinical investigation for manly years. A number of studios have compared the effect used anticholinergica and anticholineaterase. In most studies, the druga were administered separately or simultaneously. Furthermore these studios have ignored any possible affects that the general inhalation aneathetics used during surgery might have had during reversal of neuromusclar Block. Recently, the volatile anesthetics which mar hove a significant role in heart rate during administration of atropine and neostigmine were reported. This study was undertaken to investigate those effects of halothane and enflurane on heart rate chances during reversal of neuromuscular b1ock with glycopyrrolate (0.7 ug/kg) and pyridoatigmine (0.2 mg/kg) which was given either separately or simultaneously have been used on 40 cartes at Depatment of Anesthesiology, Hanyang University Hospital from October 1985 to June 1786. The results were as follows : 1) There were not a significant differences on age, height and weight in compare with subgroups. 2) The changes of systolic and diastolic blood pressure were not a significant statistica-llr in compare with subgroups. 3) The changes of heart rate were showed that Initial increasing and decreasing of base-line level at 10 minutes were statistically significant in compare with subgroups. (p<0.0001) 4) Tachycardia were observed as following sequence; E : G --> P>E:G +P>H : G+P > H : G --> P and bradycardia were as following sequence; H : G --> P>H : G+P>E : G --> P=E : G+P.
Anesthesiology ; Anesthetics ; Atropine ; Blood Pressure ; Bradycardia ; Enflurane* ; Glycopyrrolate* ; Halothane* ; Heart Rate* ; Heart* ; Inhalation ; Neostigmine ; Neuromuscular Blockade* ; Pyridostigmine Bromide* ; Tachycardia

Total of 311 cases who were admitted to pediatric departmenr of Kyung Hee University Hospital from October, 1971 to December, 1975 were studied clinically about the cases in various age group. The results are as follows. 1) Convulsion was most frequent in children between 6months and 3years (38%), but it was least frequent in children from 10years to 15 years (7%). 2) The most common cause of convulsions in children was febrile convulsion(30.5%). 3) Tetanus (50.9%) was most frequent cause of convulsion in the neonatal period. 4) Febtile convulsion was most common in infants from one month to six months. 5) The most common cause of conculsions in infants from six months to three years was febrile convulsion (47.8%). 6) In children more than three years of age, idiopathic epilepsy was most frequent cause of convulsion (3 to 10 years and 10 years to 15years , 36%, 72.7% respectively).
Child* ; Epilepsy ; Humans ; Infant ; Seizures* ; Seizures, Febrile ; Tetanus