1.Exercise induced delayed bronchoconstriction in children with asthma.
Eun Jin CHOI ; Hyo Kung SHIN ; Un Ki YOON ; Ji Sub OH
Journal of the Korean Pediatric Society 1992;35(6):769-775
No abstract available.
Asthma*
;
Asthma, Exercise-Induced
;
Bronchoconstriction*
;
Child*
;
Humans
2.A clinical study of Henich-Schonlein purpura in childhood.
Jong Won JEONG ; Sun Hee JEONG ; Un Ki YOON ; Ji Sub OH
Journal of Asthma, Allergy and Clinical Immunology 1998;18(4):672-680
BACKGROUND AND OBJECTIVE: The clinical manifestation of Henoch-Schonlein purpura and existance of renal involvement may influence on its course and prognosis. To verify prevention with early administration of steroid, we studied the efficacy of corticosteroid treatment. MATERIAL AND METHOD: We analysed 65 children under 15 years of age with Henoch-Scho nlein purpura according to their age, sex, and seasonal incidence. Forty children showed typical skin lesions, arthralgia and abdominal pain. We have divided them two groups. Group A consisted of 20 children who received 1 mg/kg of prednisolone/perday for 2 weeks and group B did not. We carried out their physical examination and urinalysis monthly for a year. RESULT: The main clinical manifestations were skin rash(100% ), abdominal symptoms(41.5 %), joint symptoms (49.2%), and renal involvement(34%). As for gastrointestinal symptoms, abdominal pain(66.7% ) was most commonly observed one and others were nausea or vomiting (44.7%) and melena(25.9%). The joint involvement was observed mostly in knee(56.3%) and ankle joint(31.3% ), Hematuria was observed in all cases with renal involvement and proteinuria, in 28% of them. The improvement of renal manifestations were noted in 84.2% of them within 4 months. Mild elevation of IgA was more frequently observed in renal involvement group than non-involved group (p< 0.01). There were no significant differences in immonologic parameters such as IgG, IgM, IgE, duration of the acute phase and severity of cutaneous symptoms between two growps. None of steroid treated growp showed progression of nephropathy. Of the 20 non-steroid treated growp, 2(10%) developed nephropathy. Conclusion We may suggest that existance of renal involvement in Henoch-Schonlein purpura influences its course and prognosis.
Abdominal Pain
;
Ankle
;
Arthralgia
;
Child
;
Hematuria
;
Humans
;
Immunoglobulin A
;
Immunoglobulin E
;
Immunoglobulin G
;
Immunoglobulin M
;
Incidence
;
Joints
;
Nausea
;
Physical Examination
;
Prognosis
;
Proteinuria
;
Purpura*
;
Purpura, Schoenlein-Henoch
;
Seasons
;
Skin
;
Urinalysis
;
Vomiting
3.Two cases of pseudohypoparathyroidism in sibling.
Sun Whan KWON ; Hye Jin LEE ; Seon Young CHOI ; Un Ki YOON
Journal of the Korean Pediatric Society 1993;36(6):882-887
Pseudohypoparathyroidism is a medical disorder characterized by a complex disorder of renal resistance to parathyroid hormone and the mechanism underlying the disease is still unclear. The authors described two cases of pseudohypoparathyroidism in sibling,who had metabolic anomalies(hypocalcemia and hyperphosphatemia, high circulatin immunoreactive PTH)and basal ganglia calcification. Bilateral basal ganglia calcifications, which was not visible on plain skull film, was detected by CT scan of brain MRI. We report these cases with a review of related literatures.
Basal Ganglia
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Brain
;
Humans
;
Hyperphosphatemia
;
Magnetic Resonance Imaging
;
Parathyroid Hormone
;
Pseudohypoparathyroidism*
;
Siblings*
;
Skull
;
Tomography, X-Ray Computed
4.A Case of Congenital Giant Hydronephrosis.
Un Ki YOON ; Young Ok SEO ; Hong Bae KIM ; Ji Sub OH ; Ok Ji PAIK
Journal of the Korean Pediatric Society 1986;29(11):91-96
No abstract available.
Hydronephrosis*
5.A Case Report of McCune Albright Syndrome.
Kei Hag SON ; Un Ki YOON ; Soon Ok BYUN ; Ji Sub OH
Journal of the Korean Pediatric Society 1986;29(12):82-87
No abstract available.
Fibrous Dysplasia, Polyostotic*
6.A Case Report of McCune Albright Syndrome.
Kei Hag SON ; Un Ki YOON ; Soon Ok BYUN ; Ji Sub OH
Journal of the Korean Pediatric Society 1986;29(12):82-87
No abstract available.
Fibrous Dysplasia, Polyostotic*
7.A Clinical Study on Acute Appendicitis in Children.
Choong Hun KIM ; Un Ki YOON ; Soon Ok BYUN ; Ji Sub OH
Journal of the Korean Pediatric Society 1985;28(12):1207-1215
No abstract available.
Appendicitis*
;
Child*
;
Humans
8.A Case of Incontinetia Pigmenti Associated with Convulsions.
Young Ok SUH ; Gyun Woo LEE ; Un Ki YOON ; Ki Sub OH ; Kee Suck SUH ; Sang Tae KIM
Journal of the Korean Pediatric Society 1988;31(5):641-647
No abstract available.
Seizures*
9.Systemic Interferon-Gamma Therapy for Atopic Dermatitis.
Sun Hee JUNG ; Su Kyeong OH ; Un Ki YOON ; Ji Sub OH
Pediatric Allergy and Respiratory Disease 1999;9(2):200-209
PURPOSE: Atopic dermatitis is a chronic, inflammatory skin disease characterized by intense pruritus and an immunologic profile consistent with allergic disease. It is associated with increased eosinophil and IgE level and decreased INF-gamma production. We describe the result of a treatment with INF-gammaand assess the clinical, immunologic, and laboratory data of 12 patients with atopic dermatitis. METHODS: Twelve patients were treated for 12 weeks with 2x106 units/m2 INF-gamma by subcutaneous injection. General hematologic tests were done, and total eosinophil counts, eosinophil fractions, neutrophil fractions, and IgE levels were measured before the treatment, 2 weeks after the treatment, 12 weeks after the treatment serially. We also followed up the patients for 12 weeks after discontinuing INF-gammatherapy. RESULTS: All patients showed clinically significant improvement after 12 weeks of the systemic INF-gammatherapy. There was no clinical aggravation during the therapy period and the follow-up 4 weeks without the therapy. But the recurrence rate in the 12 weeks after discontinuing the therapy was about 40%. Eosinophil counts and eosinophil fractions were significantly decreased after the therapy. And, eosinophil counts and eosinophil fractions were increased in clinically aggravated patients during the 12 weeks of off-therapy. CONCLUSION: We conclude that INF-gammais an effective therapy in atopic dermatitis without significant side effects. The eosinophil counts and eosinophil fractions were decreased during the INF-gamma therapy, and increased in clinically aggravated patients after the off-therapy. There was no aggravation during the therapy. But 5 patients were clinically aggravated during the 12 weeks of off-therapy. Further studies for a long-term maintenance therapy and its side effect might be needed in chronic atopic dermatitis.
Dermatitis, Atopic*
;
Eosinophils
;
Follow-Up Studies
;
Hematologic Tests
;
Humans
;
Immunoglobulin E
;
Injections, Subcutaneous
;
Interferon-gamma*
;
Neutrophils
;
Pruritus
;
Recurrence
;
Skin Diseases
10.Clinical Observation in the Narrow Spinal Canal.
Joon Ki KANG ; Suck Hun YOON ; Choon Jang LEE ; Jin Un SONG
Journal of Korean Neurosurgical Society 1976;5(2):143-160
Authors analysed 25 cases of the narrow spinal canal in cervical and lumbar region, who admitted to the Catholic Medical Center, Seoul from Jan. 1970 to August 1976. Correlation between neurologic feature and radiologic finding was attempted and compared the measurements of narrow cervical and lumbar spinal canal with that of the healthy Korean. The mean anterioposterior diameter of the cervical canal in healthy Korean was 16.2mm at C4, 16.4mm. at C5, 16.6mm. at C6, and 16.4mm. at C7. The ratio of canal to vertebral body in the plain lumbar spine was 1 : 3.9 at L3, 1 : 3.8 at L4 and 1 : 3.8 at L5. The measurements of 25 cases of narrow spinal canal were significantly reduced comparing with the healthy one. The clinical symptoms were closely related to the severity of the narrow spinal canal while there was intermittent or insidious course of symptom in the group of mild narrow spinal canal. Symptom of root compression or neurogenic claudication is frequent manifestation in the severe narrow spinal canal. and the symptom is correlated to the severity of the narrowing. Urinary disturbance and pyramidal tract sign were evident in the cervical narrow canal. The characteristic myelographic feature was multiple constrictive defect at the level of the narrow canal. Common findings in laminectomy were the thickened laminae and hypertrophied ligamentum flavum in the narrow canal. Herniated disc was not found but in one case in the cervical narrow canal at surgery. The recovery of the symptom was better in the group of the narrow canal who had mild degree of narrowing or who had the symptom in short duration rather than prolonged course.
Intervertebral Disc Displacement
;
Laminectomy
;
Ligamentum Flavum
;
Lumbosacral Region
;
Pyramidal Tracts
;
Seoul
;
Spinal Canal*
;
Spine