1.Flow velocity waveforms in the maternal uteroplacental and fetal umbilical arteries-normal values from fourteen to forty-two weeks.
Korean Journal of Obstetrics and Gynecology 1991;34(9):1209-1212
No abstract available.
2.Comparison study of interferon-a combined chemotherapy versus chemotherapy only in patients with invasive uterine cervical cancer.
Hyun KIM ; Dong Hwi KIM ; Un Dong PARK
Korean Journal of Gynecologic Oncology and Colposcopy 1997;8(2):141-150
This study is to evaluate therapeutic effects between interferon-a combined chemotherapy and chemotherapy(5-fluorouracil, cisplatin) only in invasive uterine cervical cancer. The study included 35 cases of interferon-a combined chemotherapy group and 50 cases of chemotherapy(5-FU, cisplatin) only group. Then we analyzed the therapeutic effects with respect to size of tumor, number of lymphocyte subsets and NK activity, and SCC Ag(squamous cell carcinoma antigen) level in peripheral blood. (continue)
Drug Therapy*
;
Humans
;
Lymphocyte Subsets
;
Uterine Cervical Neoplasms*
3.A clinical pathological study on ovarian malignant germ cell tumors.
Chan Hwa MOON ; Ji Wook PARK ; Un Dong PARK
Korean Journal of Obstetrics and Gynecology 1993;36(9):3485-3491
No abstract available.
Germ Cells*
;
Neoplasms, Germ Cell and Embryonal*
4.Invasive Cervical Cancer in Women Aged 35 or Less.
Eun Hee CHYU ; Won Gue KIM ; Un Dong PARK
Korean Journal of Gynecologic Oncology and Colposcopy 1995;6(1):13-22
The incidence in women less than 35 years of age is increasing despite an overall decrease in newly diagnosed invasive cervieal cancer among all age groups. However the influence of young age on prognosis remains controversial. So 163 patients of invasive cervical cancer in women aged 35 or less treated from Jan. 1, 1984 to Dec. 31. 1993 at the Department of Obstetrics and Gynecology, Kosin Medical College, Pusan, Korea, were studied retrospectively. We obtained the following results; The 5-year survival rates by clinical stage were 88.7Y% in stage I b, 71.5% in stage IIa, 31.2% in stage IIb and O% in stage III or above. The lymph node metastasis rates by stage in RAH group, were 21.3% in stage I b and 31.8% in stage IIa. The lymph nodc metastasis rates by lesion size in RAH group, were 19.2% in 2cm below, 20.7% in 2-4cm and 40.0% in 4cm above. The 5-year survival rates in RAH group were 74,9% in lymph node positive group and 89.0% in lymph node negative group. The recurrenee rates by clinieal stage were 0% in stage Ia, 20.6% in stage I b, 22.2% in stage IIa, 50.0% in stage Ilb and 90.9% in stage III or above.
Busan
;
Female
;
Gynecology
;
Humans
;
Incidence
;
Korea
;
Lymph Nodes
;
Neoplasm Metastasis
;
Obstetrics
;
Prognosis
;
Retrospective Studies
;
Survival Rate
;
Uterine Cervical Neoplasms*
5.Detection of chlamydia antibody by indirect immunofluorescence technique in pelivic inflammatory disease.
Ju Hwa JIN ; Heung Yeol KIM ; Un Dong PARK
Korean Journal of Obstetrics and Gynecology 1993;36(11):3768-3773
No abstract available.
Chlamydia*
;
Fluorescent Antibody Technique, Indirect*
6.Clinical Evaluation of 103 Cases of Adenocarcinoma of the Uterine Cervix.
Seung Hak YANG ; Won Gue KIM ; Un Dong PARK
Korean Journal of Gynecologic Oncology and Colposcopy 1994;5(4):15-23
OBJECTIVE: The purpose of this study was to investigate clinical charactoristics of adenocarcinoma of the uterine cervix. STUDY METHODS: This study is a retrospective analysis of 103 patients with adenocarcinoma of cervix treated at the Kosin Medical center forom 1984 to 1993. RESULTS: The distribution by stage of disease included FIGO stage I, 51(49.6%); stage II, 32(31%); Stage III, 17(16.5%);Stage IV, 3(2.9%). The 2-year survival results for patients with stage I was 93.5%; stage II was 72.4%;stage III was 46.2% and stage IV was none survived. And 4 year survival results,'83.3/o, 591% and 33.3/o in stage I, II and III, reqxetively. The 4-year survivel rate varied significantly according to tumor size and lymph nade metastasis status-below 2cm 84.2%, 2cm~4cm 75%, above 4cm 0%: (stage I);negative node 91.3%, positive node 40% (stage I). The results of resurrent rate according to clinical stage was 11.8%, 25.8%, 84.6% and 100 % in stage I, ll, III and lV, respectively. CONCLUSION: Treatment strategies should be based on the stage of disease, tumor size, lymph node metastasis status and recurrent.
Adenocarcinoma*
;
Cervix Uteri*
;
Female
;
Humans
;
Lymph Nodes
;
Neoplasm Metastasis
;
Retrospective Studies
7.Expression of bcl-2 and p53 Protein in Invasive Cervical Cancer.
Cheon Jun LEE ; Eun Mo AHN ; Tae Hong YEO ; Dong Hwi KIM ; Un Dong PARK
Korean Journal of Gynecologic Oncology and Colposcopy 1999;10(3):272-279
Recently, the bcl-2 and p53 protein have been recognized as important factors that is contributed to programmed cell death. The objective of this study was to evaluate the prognostic significance of bcl-2 and p53 protein expression in uterine cervical carcinoma. The expression of bcl-2 and p53 in 59 cases of uterine cervical carcinoma (stage IB to IIB) were surgically treated from January 1993 to June 1994. The expression of bcl-2 and p53 was examined by immunohistochemical method using formalin fixed paraffin embedded tissue specimens. The 48 cases were squamous cell carcinoma and 11 cases were adenocarcinoma. The results were as follows: 1. The expression rate of bcl-2 protein was 28.8%(17/59) and there was no significant correlaltion between the expression of bcl-2 protein and the clinicopathologic parameters (histologic type, grade, FIGO stage, cervical invasion depth, lymph node metastasis, parametrial invasion, tumor size, neoadjuvant chemotherapy response, recurrence, survival). 2. The expression rate of p53 protein was 32.2%(19/59) and there was no significant correlation between expression of p53 protein and the clinicopathologic parameters. 3. There was significant correlation between and expression of bcl-2 and p53 protein (P 0.05). In conclusion, bcl-2 and p53 protein are thought to be possible factors in the carcinogenesis of uterine cervical carcinoma and correlate with progression of it. But further study will be required to clarify the role of bcl-2 and p53 in carcinogenesis of the uterine cervix.
Adenocarcinoma
;
Carcinogenesis
;
Carcinoma, Squamous Cell
;
Cell Death
;
Cervix Uteri
;
Drug Therapy
;
Female
;
Formaldehyde
;
Lymph Nodes
;
Neoplasm Metastasis
;
Paraffin
;
Recurrence
;
Uterine Cervical Neoplasms*
8.Diagnostic Conization of the Cerivx.
Gun Sang YOO ; Dong Hwi KIM ; Eun Hee CHYU ; Un Dong PARK
Korean Journal of Gynecologic Oncology and Colposcopy 1996;7(2):77-83
To evaluate the effectiveness of conization in the diagnosis of cervical cancer, the histopathologic finding of 464 consecutive cases were analized with respect to the cytology, punch biopsy and hysterectomy. Cold knife conization was performed under direct visualization(naked eye conization) from January, 1987 to Octorber 1994 at department of Obstetrics and Gynecology, Kosin Medical Center. The results were summerized as follows : 1. The rate of agreement and underdiagnosis of between pap smear and naked eye conization were 43.7% and 47%. 2. The rate of agreement and underdiagnosis of between punch biopsy and naked eye conization were 64.5% and 21.8% 3. Subsequent hysterectomy was done on the 382 case and their incidence of residual disease rate was 44.2%(169 cases). Their incidence of residual lesion was increased with severity of the carcinomatous change. 4. The rate of complication undergoing conization was 8.4%(39 cases).
Biopsy
;
Conization*
;
Diagnosis
;
Gynecology
;
Hysterectomy
;
Incidence
;
Obstetrics
;
Uterine Cervical Neoplasms
9.Expression of CD44 Splice Variants(v4/5 and v6), alpha-Smooth Muscle Actin, and nm23 Proteins in IB-IIB Uterine Cervical Cancer.
Hee Kyung CHANG ; Man Ha HUH ; Dong Hee KIM ; Un Dong PARK
Korean Journal of Pathology 1997;31(6):546-556
We examined the expressions of CD44 splice variants (v4/5, v6), alpha-smooth muscle actin, nm23 to evaluate their roles as prognostic factors in 70 cases of uterine cervical carcinoma (stage IB to IIB) who were surgically treated from January 1989 to June 1990 with a clinical follow-up of a minimum of 5 years. The expression was examined by an immunohistochemical method using archival formalin fixed paraffin embedded tissue. In the 70 cases, 61 cases were squamous cell carcinoma and 9 cases were adenocarcinoma. CD44v4/5, CD44v6, alpha-smooth muscle actin, and nm23 were detected in 41.4%, 70%, 100%, and 74.3% of tumor samples, respectively. CD44 splice variants and nm23 showed membrane and cytoplasmic staining of tumor cells, respectively. The expression of alpha-smooth muscle actin showed cytoplasmic staining confined to stromal cells and was classified into three grades by the extent in stromal cells: with less than 10% of stromal cells; 32.9%, 10-50% of stromal cells; 40.0%, more than 50%; 27.1%. These expressions were not correlated with histologic types, lymph node involvement, recurrence, and grades of tumor infiltrating lymphocyte (TIL). But CD44v4/5 had significantly inverse correlation with TIL (p=0.049). The expression of CD44v4/5 was significantly correlated with that of CD44v6 (p=0.05), and that of alpha-smooth muscle actin was inversely correlated with that of nm23 (p=0.049). In conclusion, in FIGO IB-IIB uterine cervical carcinoma CD44 variants, nm23, and SMA show high prevalence, however, with little prognostic significance assessed by recurrence and lymph node metastasis.
Actins*
;
Adenocarcinoma
;
Carcinoma, Squamous Cell
;
Cytoplasm
;
Follow-Up Studies
;
Formaldehyde
;
Lymph Nodes
;
Lymphocytes
;
Membranes
;
Neoplasm Metastasis
;
Paraffin
;
Prevalence
;
Recurrence
;
Stromal Cells
;
Uterine Cervical Neoplasms*
10.A case of broad ligament pregnancy associated with intraperitoneal hemorrhage.
Geun Jae YOO ; Heung Yeol KIM ; Dong Hwy KIM ; Un Dong PARK
Korean Journal of Obstetrics and Gynecology 1993;36(7):2823-2826
No abstract available.
Broad Ligament*
;
Female
;
Hemorrhage*
;
Pregnancy*