Objective:To observe the effects of hemoperfusion combined with hemodialysis (HP+HD)and hemodiafiltration (HDF)on the macro-molecules and quality of life and nutritional status of maintenance hemodialysis (MHD) patients.Methods:Sixty patients undergoing MHD were selected and randomly divided into HDF group and (HP+HD) group,with 30 cases in each group.The Leptin,interleukin-6 (IL-6 ),tumor necrosis factor-α(TNF-α)and CRP level were detected.The reduction rates of each molecule were calculated,the nutritional status and quality of life of patients were evaluated,and the differences between two groups were compared.Results:The clearance rates of Leptin,IL-6,and TNF-αin (HP+HD)group were higher than which in HDF group.After 6 months of treatment,the inflammatory markers of IL-6 , TNF-αand CRP in (HP+HD)group were significantly lower than which in HDF group,and the nutritional status and quality of life were better than HDF group as well.Conclusions:HP+HD can effectively reduce the level of macro-molecules, alleviate inflammatory status,improve nutritional status and quality of life.