1.Clinical review of Crohn's disease.
Hee Won CHUNG ; Jae Gahb PARK ; Kuhn Uk LEE ; Kuk Jin CHOE ; Jin Pok KIM
Journal of the Korean Society of Coloproctology 1992;8(2):143-150
No abstract available.
Crohn Disease*
2.An Experience in Fiberopticbronchoscopy in the Diagnosis of Pulmonary Diseases.
Hee Young SOHN ; Uk Yong LEE ; Won Young LEE ; Kiho KIM
Yonsei Medical Journal 1982;23(1):84-88
We analysed the results of the 521 bronchofiberscopies which was carried out at the Severance Hospital during 1977-1980. The purpose of the bronchofiberscopic procedures were diagnostic in 488 cases (93.8%), therapeutic in 18 cases (3.4%) and follow up observation in 15 cases (2.8%). It's major role is in the diagnosis of lung cancer and the tuberculosis in our hospital. In 190 patients of lung cancer confirmed positive typing was possible in 72.9% by bronchial biopsy, 52.6% by washing cytology. In 48 patient with tuberculosis who was not diagnosed before bronchofiberscopy, tubercle bacilli were found in 20% by AFB smear, 51% by AFB culture and 68.4% by bronchoscopic biopsy. Complications were minimal(1.9%).
Adolescent
;
Adult
;
Aged
;
Bronchoscopy/methods
;
Female
;
Fiber Optics
;
Human
;
Lung Diseases/diagnosis*
;
Lung Neoplasms/diagnosis
;
Male
;
Middle Age
3.Radiotechnologists and Radiation Exposure from PET and PET/CT Systems.
Hoon Hee PARK ; Jeongbae RHIE ; Pilkyun JUNG ; Jong Doo LEE ; Jong Uk WON ; Jaehoon ROH
Korean Journal of Occupational and Environmental Medicine 2012;24(1):86-95
OBJECTIVES: In this study, radiotechnologists who work performing PET and PET/CT methodologies were analyzed in order to find the cause for the differences in radiation exposure as they applied to general characteristics, work characteristics, knowledge, and exposure recognition or conduct. METHODS: From April 15th, 2010 to May 14th, 2010, we conducted a retrospective analysis on 80 radiotechnologists using data garnered from their individual general characteristics, work characteristics, knowledge, and exposure recognition or conduct. Their average annual radiation exposure dosages were measured using a thermoluminescence dosimeter. A multiple regression analysis was performed as a statistical tool. RESULTS: Regarding the general PET and PET/CT characteristics, when the work experience was short, the exposure dose was higher. The factors of age, marriage, work experience in nuclear medicine, PET, PET/CT, and sex were found to have statistically significant effects. The knowledge, recognition, and conduct factors for the radiotechnologists were affected by unsecure radiation exposure at the moment of carrying, unsecure radiation exposure at the moment of injection, the application of protection at the moment of injection, and the use of auto distributor. It was found that, the use of an auto distributor, efforts in reducing the radiation exposure, unsecure exposure when with a patient, and the application of protective procedures at the moment of injection affected the overall factor of radiotechnologists radiation exposure dose. CONCLUSIONS: We believe that if radiotechnologists would reduce their radiation exposure by using auto distributors, make efforts to reduce the chance of exposure, and be conscious of radiation, they would be able to reduce the radiation exposure dose even during unavoidable circumstances.
Humans
;
Lifting
;
Marriage
;
Nuclear Medicine
;
Retrospective Studies
4.Effect of Amantadine on Weight Gain Induced by Olanzapine.
Won Myong BAHK ; Kyoung Uk LEE ; Jeong Ho CHAE ; Won Hee LEE ; Taeyoun JUN ; Kwang Soo KIM
Korean Journal of Psychopharmacology 2003;14(1):23-27
OBJECTIVE: Weight gain is a commonly encountered problem associated with atypical antipsychotics, especially olanzapine. To investigate the weight reducing effect of amantadine, we conducted an prospective open label study. METHODS: We started amantadine treatment in outpatients who had gained weight during olanzapine treatment (mean dose of 11.94 mg/day, mean weight gain of 6.33 kg). Data were collected at St. Mary's Hospital, College of Medicine, The Catholic University of Korea. The add-on treatment of amantadine was given at a mean dose of 161.9 mg/day with mean duration of administration for 110.2 day. Brief Psychiatric Rating Scale (BPRS), Extrapyramidal Symptom Scale were checked to evaluate the tolerability of amantadine. RESULTS: Before administration of amantadine, the mean dose of olanzapine was 11.94+/-4.58 mg and mean duration of administration was 123.1+/-174.6 days. Body weight and BMI during this period was significantly increased mean 6.33+/-4.45 kg (Z=-3.839, p<0.001), 4.94+/-0.75 (Z=-3.724, p<0.001) respectively. Amantadine was administered mean dose of 161.90+/-58.96 mg for mean 110.2+/-78.7 days. Body weight and BMI was decreased mean 0.96+/-3.44 kg, 0.71+/-2.7, respectively. There was no deterioration in psychiatric symptoms, as shown in BPRS score decrement and no adverse effects were reported. CONCLUSION: The present data suggests that amantadine does not significantly decrease weight gain experienced by some patients during olanzapine treatment and does not worse psychotic symptoms. Randomized placebo-controlled trial should be needed to confirm these findings.
Amantadine*
;
Antipsychotic Agents
;
Body Weight
;
Brief Psychiatric Rating Scale
;
Humans
;
Korea
;
Outpatients
;
Prospective Studies
;
Weight Gain*
5.Development and Its Preliminary Standardization of Pictures of Facial Expressions for Affective Neurosciences.
Won Hee LEE ; Jeong Ho CHAE ; Won Myong BAHK ; Kyoung Uk LEE
Journal of Korean Neuropsychiatric Association 2004;43(5):552-558
OBJECTIVES: In recent years there has been a discernible increase of interest in facial expressions as a tool for affective neurosciences research which investigates the neural circuit for emotional perception and control. Though substantial researches have documented the universality of several emotional expressions, researches have shown evidences for cross-cultural differences of facial emotion recognition. Therefore the need for facial expressions of Koreans is gathering strength. Thus we developed the images of facial expressions of Korean people as a research tool for affective neurosciences and standardized them. METHODS: Three professional actors and three actresses were participated in this study (two in their twenties, two in their forties, two in their sixties). They were asked to pose each of the following facial expressions in turn: happiness, sadness, fear, anger, disgust and surprise. And facial emotion identification test was done for one hundred common person to get percent of judgment of each emotion and intensity ratings for each photographs. RESULTS: Six facial expressions in each subject were obtained. Among six emotions, subjects performed better on the recognition of happiness and worse on the recognition of fear and disgust. Also, each emotion term was presented with a 9-point (0-8) scale on which subjects rated. All emotion terms displayed 4.7-7.0 point scale. CONCLUSION: We could obtain facial expressions of Koreans for happiness, sadness, fear, anger, disgust, surprise and neutral, and then standardized them. As a tool for affective neurosciences, it can be used for the investigation of neural circuit for emotion recognition and control.
Anger
;
Facial Expression*
;
Happiness
;
Humans
;
Judgment
;
Neurosciences*
6.Development and Its Preliminary Standardization of Pictures of Facial Expressions for Affective Neurosciences.
Won Hee LEE ; Jeong Ho CHAE ; Won Myong BAHK ; Kyoung Uk LEE
Journal of Korean Neuropsychiatric Association 2004;43(5):552-558
OBJECTIVES: In recent years there has been a discernible increase of interest in facial expressions as a tool for affective neurosciences research which investigates the neural circuit for emotional perception and control. Though substantial researches have documented the universality of several emotional expressions, researches have shown evidences for cross-cultural differences of facial emotion recognition. Therefore the need for facial expressions of Koreans is gathering strength. Thus we developed the images of facial expressions of Korean people as a research tool for affective neurosciences and standardized them. METHODS: Three professional actors and three actresses were participated in this study (two in their twenties, two in their forties, two in their sixties). They were asked to pose each of the following facial expressions in turn: happiness, sadness, fear, anger, disgust and surprise. And facial emotion identification test was done for one hundred common person to get percent of judgment of each emotion and intensity ratings for each photographs. RESULTS: Six facial expressions in each subject were obtained. Among six emotions, subjects performed better on the recognition of happiness and worse on the recognition of fear and disgust. Also, each emotion term was presented with a 9-point (0-8) scale on which subjects rated. All emotion terms displayed 4.7-7.0 point scale. CONCLUSION: We could obtain facial expressions of Koreans for happiness, sadness, fear, anger, disgust, surprise and neutral, and then standardized them. As a tool for affective neurosciences, it can be used for the investigation of neural circuit for emotion recognition and control.
Anger
;
Facial Expression*
;
Happiness
;
Humans
;
Judgment
;
Neurosciences*
7.The Effect of Pleurodesis with Doxycycline in the Rabbit.
Kyoung Sook WON ; Keon Uk PARK ; Won Ho JEON ; Jae Jung BAIK ; Yeon Tae JEONG ; Jung Il SUH ; Jin Hee SON
Tuberculosis and Respiratory Diseases 1994;41(5):531-536
BACKGROUND: The intrapleural instillation of tetracycline for pleural sclerosis had been most commonly used in patients with symptomatic malignant pleural effusion or recurrent pneumothorax for a long time. Unfortunately, at a time of expanding use of this agent, the production of injectable tetracycline hydrochloride used for pleurodesis was discontinued by its sole manufacturer in mid-1991 because the manufacturer was unable to meet US Food and Drug Administration purity standards. So we performed a preliminary study of doxycycline, as a alternative pleural sclerosant on rabbit pleura and compared its efficacy with that of tetracycline. METHOD: Eighteen New Zealand white rabbits weighing 2 to 3kg(mean 2.6kg) were divided into three groups. In each groups, one tetracycline(20 mg/ml/kg) and two doxycycline solutions(7 mg/ml/kg and 20 mg/ml/kg) instillated into the right pleural space through an 18-gauge angiocath with care to prevent pneumothorax. All rabbits were sacrificed after 28 days. RESULTS: 1) In the group of tetracycline 20 mg/ml/kg(six rabbits), five rabbits showed partial pleural symphysis with several fibrous bands, and one rabbit died on 22th day. 2) In the group of doxycycline 7 mg/ml/kg(six rabbits), three rabbits showed partial pleural symphysis and the other three rabbits showed complete pleural symphysis without necrosis of underlying parenchymal lung tissue. 3) In the group of doxycycline 20 mg/ml/kg(six rabbits), two rabbits showed complete pleural symphysis without lung necrosis, another two rabbits showed complete pleural symphysis with lung necrosis, and the other two rabbits died on 4th and 13th day, respectively. CONCLUSION: We concluded that doxycycline is a highly effective sclerosing agent having stronger pleurodesis effect with that of tetracycline by dose base and its optimal dosage was considered as 7 mg/ml/kg with minimal complications.
Doxycycline*
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Humans
;
Lung
;
Necrosis
;
Pleura
;
Pleural Effusion, Malignant
;
Pleurodesis*
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Pneumothorax
;
Rabbits
;
Sclerosis
;
Tetracycline
;
United States Food and Drug Administration
8.Evaluation of Temporal Trends of Lead Exposure in Korean Workers Using Workplace Monitoring Data
Dong-Hee KOH ; Sangjun CHOI ; Ju-Hyun PARK ; Sang-Gil LEE ; Hwan-Cheol KIM ; Inah KIM ; Jong-Uk WON ; Dae Sung LIM ; Hoekyeong SEO ; Dong-Uk PARK
Journal of Korean Medical Science 2023;38(34):e271-
Background:
Lead, which is widely used in various industrial settings, is a major health hazard for manufacturing workers. Therefore, control of lead exposure has been implemented in an effort to prevent lead-related health problems. In this study, our aim was to evaluate temporal trends in occupational lead exposure in Korean lead workers using data from monitoring of workplace exposure.
Methods:
A nationwide work environment monitoring database, data from a work environment monitoring institution, and data extracted from a review paper were utilized. Different versions of standard industrial classification codes were aligned with the 10th Korean Standard Industrial Classification, which is generally consistent with the 4th revision of the International Standard Industrial Classification. The multiple data sources were combined and temporal trends over the period from 1994–2021 were estimated. In addition, separate estimation of temporal trends in the storage battery manufacturing industry over the period from 1987–2021 was also performed.
Results:
A total of 444,296 personal airborne lead measurements were used for the estimation process. The temporal trends in occupational exposure to lead declined by −6% annually over the study period. In particular, levels of lead exposure in the storage battery manufacturing industry showed a steeper decline of −12% annually.
Conclusions
Findings of our study showed that occupational exposure to lead declined over the period from 1994 to 2021 in Korea. However, adverse effects of exposure to lead on health should be regarded with caution. The results will be useful in conduct of epidemiological studies examining lead-related effects on health.
9.Early Motor Balance and Coordination Training Increased Synaptophysin in Subcortical Regions of the Ischemic Rat Brain.
Han Gil SEO ; Dae Yul KIM ; Hee Won PARK ; Shi Uk LEE ; Sung Hye PARK
Journal of Korean Medical Science 2010;25(11):1638-1645
The aim of this study was to evaluate the effect of early motor balance and coordination training on functional recovery and brain plasticity in an ischemic rat stroke model, compared with simple locomotor exercise. Adult male Sprague-Dawley rats with cortical infarcts were trained under one of four conditions: nontrained control, treadmill training, motor training on the Rota-rod, or both Rota-rod and treadmill training. All types of training were performed from post-operation day 1 to 14. Neurological and behavioral performance was evaluated by Menzies' scale, the prehensile test, and the limb placement test, at post-operation day 1, 7, and 14. Both Rota-rod and treadmill training increased the expression of synaptophysin in subcortical regions of the ischemic hemisphere including the hippocampus, dentate gyrus, and thalamus, but did not affect levels of brain-derived neurotrophic factor or tyrosin kinase receptor B. The Rota-rod training also improved Menzies' scale and limb placement test scores, whereas the simple treadmill training did neither. The control group showed significant change only in Menzies' scale score. This study suggests that early motor balance and coordination training may induce plastic changes in subcortical regions of the ischemic hemisphere after stroke accompanied with the recovery of sensorimotor performance.
Animals
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Brain Ischemia/metabolism/physiopathology
;
Brain-Derived Neurotrophic Factor/metabolism
;
Dentate Gyrus/metabolism
;
Disease Models, Animal
;
Hippocampus/metabolism
;
Immunohistochemistry
;
Male
;
Motor Activity
;
Neuronal Plasticity/physiology
;
Physical Conditioning, Animal
;
Physical Therapy Modalities
;
Rats
;
Rats, Sprague-Dawley
;
Receptor, trkB/metabolism
;
Stroke/*metabolism/physiopathology
;
Synaptophysin/*metabolism
;
Thalamus/metabolism
;
Time Factors
10.Psychometric Properties of Korean Version of Drug Attitude Inventory(KDAI-10).
Bo Hyun YOON ; Won Myong BAHK ; Kyung Uk LEE ; Chang Hee HONG ; Ja Kyung AHN ; Myung Kyu KIM
Korean Journal of Psychopharmacology 2005;16(6):480-487
OBJECTIVE: The aim of this study was to test the psychometric properties of Korean version of 10 items of Drug Attitude Inventory (KDAI-10). METHODS: A total of 157 stabilized schizophrenic patients were entered into the study after completion of screening tests. They completed the KDAI-10. And then they were interviewed with various scales such as Subjective Response Scale (SRS), Positive and Negative Syndrome Scale (PANSS), Extrapyramidal Side Effects Rating Scale (ESRS), and Global Assessment of Functioning (GAF). Correlations of KDAI-10 with these scales were tested. RESULTS: The Cronbach's alpha used to measure the internal consistency of the scale, was high (0.83). Principal component analysis with varimax rotation produced 2 factors, which explained 50.37% of the total variances. The First factor including 6 items was the positive subjective feelings and the second factor including 4 items was the negative subjective feelings, which were identical to the original authors'. Individual item correlations with total scores were all statistically significant (r=0.48-0.72, p<.001). And correlations of KDAI-10 with SRS, PANSS, ESRS and GAF showed that they were significantly correlated. CONCLUSION: Although the results were not quite satisfactory, KDAI-10 was demonstrated to have good reliability and construct validity.
Humans
;
Mass Screening
;
Principal Component Analysis
;
Psychometrics*
;
Schizophrenia
;
Weights and Measures