"Symptom set" was changed into "combined set of syndrome factors" by exploring the mapping relationship be-tween symptom and syndrome factors,among which the ones meeting the definition of pathogenesis were chosen to further form the"pathogenesis set" under the ISOR combination principle,so as to build a new syndrome factor system of"symptom collection-syndrome factor collection-pathogenesis collection",which is not only beneficial to perfect the syndrome factor sys-tem,but also a new thought for applying mathematics and computer science to Chinese medicinal research.