Animals ; Heart ; drug effects ; Hippophae ; Liver ; drug effects ; metabolism ; Male ; Myocardium ; metabolism ; Oxidative Stress ; Plant Oils ; pharmacology ; Rats ; Rats, Sprague-Dawley

Objective To compare the predictive value of glomerular filtration rate (GFR)estimated by the Cockcroft-Gault formula or the modification of diet in renal disease (MDRD) equation and serum creatinine for in-hospital and long-term mortality post coronary artery bypass graft surgery (CABG).Methods Clinical data of 5559 consecutive patients undergoing isolated CABG were retrospectively analyzed. The main outcomes were in-hospital mortality and long-term mortality. Estimated GFR was calculated by the Cockcroft-Gault formula and MDRD equation respectively.Receiver-operating characteristic curves and Cox's analysis were used for the comparison.Results Follow-up was complete in 5485 patients (97.6%).Analysis of receiver-operating characteristic curves showed that GFR estimated by the Cockcroft-Gault formula had a maximal accuracy for predicting in-hospital mortality (area under the curve:0.755,P＜0.01).Multivariate logistic analysis and the Cox's analysis results indicated estimated GFR＜60 ml ·min~(-1)·1.73 m~(-2) base on the Cockcroft-Gault formula was an independent risk factor for in-hospital and long-term mortality(hazard ratio 4.51 for in-hospital mortality,P＜0.01 ;hazard ratio 1.54 for long-term mortality,P＜0.01),both Cockcroft-Gault formula and MDRD equation were superior to serum creatinine for predicting in-hospital and long-term mortality post CABG.Conclusion GFR estimated by the Cockcroft-Gault formula was superior to GFR estimated by the MDRD equation for predicting in-hospital mortality,and estimated GFR was superior to serum creatinine for predicting in-hospital and long-term mortality.