1.Investigation on secondary metabolites of endophytic fungus Talaromyces purpurogenus hosted in Tylophora ovate.
Jing-Yi ZHAO ; Zhen LIU ; Sen-Feng SUN ; Yun-Bao LIU
China Journal of Chinese Materia Medica 2020;45(6):1368-1373
Eight compounds,(R)-2-[5-(methoxycarbonyl)-4-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl]acetic acid(1),(3S,4R)-3,4-dihydro-3,4-epoxy-5-hydroxynaphthalen-1(2H)-one(2),(-)-mitorubrinol(3),(-)-mitorubrin(4),(±)-asperlone A(5), terreusinone(6), verrucisidinol(7) and cerebroside C(8) were isolated from the endophytic fungus Talaromyces purpurogenus by using various column chromatographic techniques. Their structures were identified by NMR, MS, CD and optical rotation. Compounds 1 and 2 were new compounds. Their anti-diabetic activities in vitro were evaluated, and compound 1 showed moderate inhibitory activity toward XOD at 10 μmol·L~(-1) with the inhibition rate of 69.9%.
Endophytes/chemistry*
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Hypoglycemic Agents/chemistry*
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Secondary Metabolism
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Talaromyces/chemistry*
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Tylophora/microbiology*
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Xanthine Oxidase/antagonists & inhibitors*