Background: Monitoring antimalarial drug quality should be conducted regularly in locals to enhance the effect of treatment for malaria \r\n', u'Objective: to study and analyze antimalarial drug quality\r\n', u'Subjects and methods: The study was carried out in 2007 for 5 provinces supported by the Global Fund: Ha Giang, Dien Bien, Thanh Hoa, Quang Tri and Gia Lai. Material were malaria drugs: artesunat, chloroquin, quinine, mefloquin, fansidar\u2026etc\r\n', u'Results and conclusion: The strict supervision on the anti-malarial drug quality by the National Malaria Control Program was very good and no substandard antimalarial drugs were detected. Evaluation of antimalarial drug quality and control was made for finding out the counterfeit drugs through sentinel sites in both private and public sectors. A total of 268 samples were collected, of which 13 samples were found substandard drugs (8 samples collected in private and 5 samples in public sectors). No counterfeit drugs were found. \r\n', u'
Antimalarial drug ; quality ; monitoring

A popular approach for the study of estrogen receptor α inhibition is to investigate the protein-protein interaction between the estrogen receptor (ER) and the coactivator surface. In our study, we investigated phytochemicals from Rubus coreanus that were able to disrupt ERα and coactivator interaction with an ERα antagonist. The E-screen assay and molecular docking analysis were performed to evaluate the effects of the estrogenic activity of R. coreanus extract and its constituents on the MCF-7 human breast cancer cell line. At 100 µg/mL, R. coreanus extract significantly stimulated cell proliferation (574.57 ± 8.56%). Sanguiin H6, which was isolated from R. coreanus, demonstrated the strongest affinity for the ERα coactivator-binding site in molecular docking analysis, with a binding energy of
Breast Neoplasms ; Cell Line ; Cell Proliferation ; Estrogens ; Humans ; Molecular Docking Simulation ; Phytochemicals ; Rubus