1.Results of the cause occasion and form of zygomatic fractures
Mongolian Medical Sciences 2012;160(2):32-34
Introduction: We decided to study the prevalence of zygomatic fracture among the population which presented one variation of facial fractures has been occurred more often from traffic accidents, sports trauma and other injures with high-impact. There were the quantity of patients with zygomatic fractures has been treated at in-patients and out-patients.In 1998,Gerhard S., Joseph A. (USA) reviewed 259 patients with zygomatic fractures and found that ZMC (zygomaticomaxillary complex) fractures occurred in 78.8% of patients, arch fractures occurred in 10.8% and 10.4 % of patients, respectively. Of note, displaced or comminuted fractures were found in 59.3% of patients with isolated zygomatic arch fractures.Goal: The main purposes of this study are to determine cause of zygomatic fractures, the occasion and form of fractural lines.Specific objectives:1. To reveal the occurance of zygomatic fracture2. To identify etiology of zygomatic fracture3. To classify the configuration of zygomatic fractureMaterials and Methods: The study of the science discussion be provide necessity which faced on medical science. Therefore: In-patients with zygomatic fracture treated in State of central hospital. The data of this study composed 13314 in-patients records who treated 480 patients at maxillofacial department of State hospital between 1996-2011. Objectives representative expecting is 8-10%.Result: There were 3.61% 480 patients with zygomatic fractures of total patients 13314 treated in Maxilla facial-oral surgery clinic from 1996-2011. The zygomatic fractures have been occurred mostly in the everyday life injures and traffic accidents 61.25% have resulted from beginning fight. There were arch fractures 17,53%, zygomatic fractures 18.31%. There were the main fractures 64.16% in the zygomatic have occurred in the maxillary sinusitis.
2. HEALTH STATUS SCORES OF ULAANBAATAR CITY POPULATION (18-25YEARS) OF MONGOLIA
Munkhjavkhaa T ; Zevgee T ; Tuul M ; Lhagva L
Mongolian Pharmacy and Pharmacology 2013;2(1):32-
background: Our country’s aging for men of 30-39, 40-49 ages it was accelerated aging process and very accelerated aging process. Aging for men of 50-59, 60- 69 ages it was normal aging and slowed aging process. Aging for women 30-39, 40-49 ages it was normal end slowed aging process. Aging for women 50-59, 60-69 ages it was slowed and significantly slowed aging process. Otherwise, aging for young groups was accelerated and very accelerated aging process, aging for old groups was normal, slowed and significantly slowed aging process. The aging process of men was more quickly than women in our country [1].Aim of the stady: To define biological aging, aging indexes and adaptation potential in population of 18- 25 years old of Ulaanbaatar city.Materials and methods: In total 537 person of 18- 25 years from Ulaanbaatar city were chosen for the research study which was conducted in 2012. Biological age levels were assessed on the basis of following standards. True biological age was determined with clinical-physiologycal indexes and biological age with chronological age. Adaptation potential have been studied with the help of special indexes and analysis were made with the use of regression method. Quantative data of the study has been processed with the use of statistical data processing software SPSS- 19.Results and discussions: Body mass index of 18-25 aged men of Ulaanbaatar city was 22.2146, cachexia 7.82%, normal weight 79.32%, more weight 10.24%, obesity 2.6%, Aging for men of 18-25 ages it was significantly slowed aging process of men was observed 0.37%, slowed aging process 0.55%, normal aging 0.93%, accelerated aging process 12.47%, and very accelerated aging process was 85.66%. The portion of men with normal adaptation potential was 55.67%, adaptation functional tension was 43.76%, unsatisfactory adaptation was 0.55%.Conciusions:1. The portion of cachexia 7.82%, more weight 10.24%, obesity 2.6% of 18-25 aged men of Ulaanbaatar city.2. Health status was abnormal 98.13% of 18-25 aged men of Ulaanbaatar city.3. The portion of 18-25 aged men of Ulaanbaatar city adaptation functional tension 43.76%, unsatisfactory adaptation was 0.55%.References:1. 1 .Tuul M., Lhagva L., Sukhbaatar Ts., AmgalanbaatarD. “Aging biology of Mongolians” III book. “Admon” puplisher. Ulaanbaatar. 2009.2. Open society forum. “Policy of young” abstract. UB. 2010.3. Leonid Kalichman, Ida Malkin, Gregory Livshigts, Oleg Pavlovsky, Valery Bathvich. Variation of Skeletal Biomarkers of biological Aging in a Chuvashian Population: A Longitudinal Stady. American journal of human biology 19:74-81. 2007.4. Apanacenco G.L, Popava L.A, “Medical Valeology”. Kiev. 2000.
3.Using a Liver Biopsy for Clinical Practice
Davaadorj D ; Ulziisaikhan T ; Tuul B ; Batchuluun P ; Erdenebileg B
Mongolian Medical Sciences 2009;148(2):52-54
Within the spectrum of diagnostic procedures in hepatology, the procurement of a liver specimen plays an important role. The method has been diversifi ed to encompass not only different needle types for cutting and aspiration but also different routes proceeding transvenously or transcutaneously. Over the subsequent 50 years the technique of obtaining liver biopsy samples has been modifi ed regarding the approach, the needle type, and the combination with diagnostic imaging techniques such as ultrasound, computed tomography, angiography and laparoscopy. Histological analyses are capable of establishing the etiology of a chronic or acute liver disease, are determined the inflammatory activity (Grading), degree of fi brosis/cirrhosis (Staging), are relevant for the prognosis of the patient and for indication for cost-intensive as well as potentially side are effect-prone therapies. In general, the accepted mortality rate from liver biopsy is between 0,1% and 0,01%. Among the most feared complications of liver biopsies are hemorrhage, seeding of cancer cells, infections, and injury to the viscera. The increasing number of liver transplant patients within the hepatological spectrum requires regular, safe, and high quality biopsies and their appropriate.
4.Result of stereometric research study of cardiomyocytes in cardiovascular diseases
Tuul G ; Odgerel TS ; Gerelee KH ; Batbayr KH ; Lhkaga L ; Zevgee T
Mongolian Medical Sciences 2011;172(2):27-32
In 2006, by the news of National Center of Health Development, morbidity of cardiovascular disease was 501.84 per 10000 people. It’s increased by 2 times than over 10 years.Goal: To study and to determine stereometric research, mathematic modeling and histologicalcharacteristic on cardiomyocyte of arterial hypertension (AH), acute myocardial infarction (AMI) and chronic rheumatoid fever (CRF).Materials and Methods: It was prepared sections for histometric materials from muscular of left ventricle. Linear measurement and number of cardiomyocyte per area of materials were carried out by computermicroscope “Leica” with program Diskus 3.2 version from German. On linear measurement of AH, AMI and CRF were processed by mathematic modeling. On ratio of cytoplasm and nucleus and histological characteristics were analyzed by chi-square testResults: Results of stereometric research on cardiomyocyte On AH volume of cardiomyocyte was 5788.22±40.99mkm3, volume of the nucleus - 806.47±12.86mkm3, ratio cytoplasm and nucleus 1:7 and number of cells per area was 10.On AMI volume of cardiomyocyte was 3240.94±48.96mkm3, volume of the nucleus - 693.85±12.76mkm3, ratio cytoplasm and nucleus 1:5 and number of cells per area was 16. On CRF volume of cardiomyocyte was 5341.06±63.4mkm3, volume of the nucleus - 801.5±15.96mkm3, ratio cytoplasm and nucleus 1:7 and number of cells per area was 11. In comparatively healthy condition at 20 to 30 years old population of Mongolia the volume of cardiomyocyte was determined 1063.17mkm3, volume of nucleus 406.69mkm3, ratio cytoplasm and nucleus 2.6 and number of cells per area was 31. Result of histological research of myocardial muscle. By the research of the difference between histological characteristic was confirmed that all of this characteristics have real main difference. Conclusions: It was confirmed difference with statistical probability by that determined volume of the cardiomyocyte 5788.22±40.99mkm3 in AH, 3240.94±48.96mkm3 in AMI and 5341.06±63.4mkm3 in CRF. Quantity of cells per area was in AH - 10, in AMI – 16 and in CRF 11, but in comparatively healthy condition it was 31.
5.The study of androgen receptor gene cag and ggn polymorphism in relation with androgen status
Munkhtogtokh J ; Buyankhuu T ; Tuul B ; Oyun-Erdene R ; Munkhtsetseg J
Mongolian Medical Sciences 2013;166(4):6-8
Background: Discrepancies in the sensitivity to biological effects of the androgens, exerted through the binding of the hormone to the androgen receptor (AR), may also be involved in the inter-individual variation of T as well as in age related decline. The human androgen receptor (AR), located on chromosome Xq11-12, is a transcription factor regulating the development of male reproductive organs in the fetus and secondary sex characteristics at puberty in response to testosterone (T) and 5a-dihydrotestosterone (DHT). The AR contains two polymorphic regions, the (CAG)nCAA repeat encoding polyglutamine, and the (GGT)3GGG(GGT)2(GGC)n repeat encoding polyglycine, commonly referred to as the CAG and GGN repeats respectively. The aim of this study is to investigate the effect of the human androgen receptor genes CAG and GGN repeat polymorphisms in relation with androgen level.Materials and Methods: Sample collection: 180 male, the medical data of these volunteers were obtained and determined some androgen hormones at first phase of study in 2010-2011 (total testosterone (TT), free testosterone (FT) and bioavailable testosterone (BAT)). To determine CAG/GGN repeats length in exon of androgen receptor gene, using frozen serum as a source of deoxyribonucleic acid (DNA). DNA was extracted from blood samples (200 ml) using High PurePCR Template Preparation Kits.Results: The 180 men whose age is at least 40 were involved in our research and their average age was 55.1±10.3. The 46.7% (84) of the participants presents CAG gene, the 6.1% (11) of the participants presents GGN gene while the 25.5% (46) of the participants presents both CAG and GGN genes. However, the 21.7% of 39 men not presents CAG and GGN genes.Conclusion: The free testosterone level was significantly decreasing with aging. However, the appearance of CAG gene polymorphism was significantly higher in more aged people. Decline of free testosterone level in participants with CAG and [CAG+GGN] combined form was stronger than in people with GGN gene polymorphism and CAG, GGN both undetected people. But the level of bioavailable testosterone was decreasing with aging and the appearance of CAG gene polymorphism (r=-0.425, p=0.01) and [CAG+GGN] combined form (r=-0.491, p=0.028) was also increasing.
6.To the problem of colorectal cancer and its pathological diagnose
Adilzaya D ; Galtsog L ; Hosbayar T ; Battulga A ; Tuul B ; Bayarmaa E
Mongolian Medical Sciences 2010;153(3):42-47
BackgroundColorectal cancer takes the second place in the highly developed countries morbidity increases, for females it takes place after breast cancer, for males after lung cancer colorectal cancer occupies about 3-5% from the cancer of digestive tract. In the western Europe, united states of America it occuries 12.6% on males and 14% on females, for Pathological structure it occurs mostly in the proximal part and adenocarcinoma is diagnosed 95%. Colorectal carcinoma occurs more at the age of 20-40 but people aged 40-50 are mostly affected and males are affected more. Lately it has tendency of increasing amond the population 40-120 case on 100000 in a year approximately 5-10 people are affected newly. For our country by health statistical information colon cancer was 94 from it 49 occur on females, cancer of rectal and anus canal was 237, from it 99 occur on females, 37 case of colorectal cancer are registered newly in a year approximately, 19 occurs on females cancer of rectal and anus canal was 45 from them 16 are registered newly on females the number of patients with colorectal cancer has tendency of increasing. Among Mongolian population morbidity of colorectal cancer is increasing nowadays but any research has not been done to reveal pathology early and to diagnose. This became base of our research work.GoalAim of our study is to define peculiarity of colorectal cancer and its early pathology and to study some factor of aetiology connectea with cancer forming.Objectives:1. To define peculiarity of pathology of colorectal cancer.2. To diagnose early pathology of colorectal cancer by pathological method.3. To diagnose colorectal carcinoma by international histological classification and determine cell secretion degree.4. To define some genetic peculiarity of factors which affects to colorectal carcinoma.Novelty of research workNovelty of research work is to study colorectal carcinoma and its early pathology in combination with the method of endoscopy and molecular biology.Materials and MethodsIn the research 315 biopsy material of 142 patients with colorectal carcinoma of 2004-2008, 56 biopsy material of colorectal endoscopy of 2007-2008 are involved.1. Histological basic painting method.2. Method of molecular biology. We revealed affect of human papilloma virus infection in 39 surgical and endoscopyic material by using general GP5, GP6, MY11 primer in PSR.ResultsIn our study totally 198 people were involved from them (average age 45.8+ - 0.4), 46.0%(n=91)-male, 54% (n=107) female. If we see people involved in the study by age classification, 8 (5.9%) at the age of 20-29, 21 (10.3%) at the age of 30-39, 39 (19.3%) at the age of 40-49,45 (22.4%) at the age of 50-59, 56 (27.7%) at the age of 60-69, over 70-79 (14.3%). If we see colorectal carcinoma by anatomical location most location was in 45 (22.7%) in sigma, 52 (26.2%) in rectus. Seeing from endoscopic biopsy analyse pathology which involved whole colorectus occupied 10 (35.6%). By international histological classification of cancer which was adopted from WHO. In our study polyp occupies 21 (10.6%), adenoma 24(12.1%), adenocarcinoma 137 (69.2%), metastatic carcinoma 6 (3%), chronic inflammation or with change dysplasia 10 (5.1%). If we see endoscopic biopsy analyse it is 56 (28.3%) of people involved in the research. Hyper plastic polyp 21 (36.1%), adenoma 6 (25%), adenomatous polyp 8 (33.3%) occupces, Tubular adenoma polyp 7 (29.2%), villous adenoma 3 (12.5%) from carcinoma adenomatous carcinoma occupces 98 (71.5%), mucous carcinoma 7 (5.1%), carcinoma with flat cell 8 (5.8%), carcinoma with ring cell 5 (5.1%), carcinoma witout secretion 13 (9.5%), carcinoma with metastases 6 (4.3%), one of factors of etiology which affects to colorectal carcinoma is human papilloma virus. In the biopsy material of surgery and endoscope involved in the research it reveals negative in sensitive primer which reveals all the type of papilloma virus.Conclusions:1. Colorectal carcinoma occurs 19.3% at the age of 40-49, 22.4% at the age of 50-59, 27.7% at the age of 60-69, it has tendency of increasing rohen age becomes older. It occurs 14% over 70.2. By location of anatomy colorectal carcinoma it occupies 50-60% in sigma and rectus.3. Noncarcinomous polyp of colorectal carcinoma is situated in many parts of intestine carcinoma with many polyp occupies 35.6%of total carcinoma.4. By histological classification mostly carcinomous and noncarcinomous carcinoma of epithel and adenomous cell originated occupy.5. Papilloma virus hasn’t been releaved in the sample endoscopic sample.
7.The attack rates of the pandemic influenza infection, Ulaanbaatar, November 2009
Amarzaya S ; Altanchimeg S ; Suvd B ; Oyun M ; Enkhjargal T ; Tuul TS ; Dolgorkhand A ; Surenkhand G ; Ambeselmaa A
Mongolian Medical Sciences 2010;152(2):47-52
BACKGROUND: In Ulaanbaatar, the first case of the pandemic influenza infection has been reported on 12 October 2010.By November 9, a total of 929 cases laboratory-confirmed had been reported to National Center for CommunicableDiseases (NCCD). Of these cases reported, 9 people died.METHODS: The objectives of the study were to describe patients who admitted and hospitalized at NCCD and to determineoverall attack rates among health workers, secondary attack rates among students of colleges and universities. Datawas analyzed using Epi-Info2000.RESULTS: Among 929 of laboratory-confirmed cases, 50.3% (95% CI 43.0-57.5) were males aged 23 (±14.9) in averagewith youngest – 7 months, oldest – 76 years old. Data analysis by districts among the hospitalized patients, showed32.8% (139) of total cases in Bayanzurkh district including the first case of the pandemic influenza infection. The majorityof patients who admitted and hospitalized to NCCD mostly experienced fever (288, 68.1%), dry cough (251, 59.3%),headache (203, 48.0%), sore throat (175, 41.6%). With 1020 physicians and health workers in total, 41.4% (422) ofthem work at NCCD, 35.4% (361) – at MCHRC. 11.1% of health workers out of total become ill with pandemic H1N12009 (overall attack rate 11.1%) with the most common symptom, 380C and higher fever (100.0%, 113), sore throat(83.2%, 94), cough (76.1%, 86) and runny nose (59.3%, 67). The higher attack rates of health workers by occupationwere doctor (18.0%) and auxiliary (13%). The secondary attack rates among university students for influenza-likeillness(ILI) were 12.9%. These secondary attack rates were higher among students of art’s college as compared withother universities (52.4%). For students, the main clinical symptoms were fever + sore throat (75.0%, 18), fever+ cough(70.8%, 17).DISCUSSION: In China, as of 27 September, 2009, from reported total 19981 cases infected with pandemic influenza,61.0% were males, mean age was 17, mainly affected with 83% school students that consistent with our study result.The similar results on clinical symptoms were obtained in Russia. Out of 130 patients, 28.6% had 380Ñ and higherfever, for 54.3% the body temperature reached 38.1-390Ñ where as 17.1% - higher 390Ñ and 96% had cough, 89%had muscle ache, 65% had headache, 14% had diarrhea.
8.The research of logistic regression model and correlations between blood plasma melatonin (MLT) and epidermal growth factor (EGF) with index of skin type of the body, cardiovascular system, biological age and adaptive capacity assessment of relatively healthy people in Uvs province
Buyan-Orshikh S ; Tuya N ; Tsanjidmolom A ; Odgerel TS ; Amgalanbaatar D ; Lkhagva L ; Zevgee T ; Tuul M
Mongolian Medical Sciences 2016;178(4):12-18
BackgroundIn Mongolia scientists have been doing research about skin disease and process of aging. Howeverthere has not enough study material about skin aging process which is the key indicator of aging andhow that affect to Mongolian people.GoalMain purpose is to study correlations between main index of skin type of the body, cardiovascularsystem, biological age, epidermal growth factor and blood plasma melatonin, within the people of Uvsprovincial center as they are relatively healthy people.Material and MethodsResearch works were done using cross sectional study model in years 2015-2016, within randomlychosen 400 citizens of Ulaangom city, counted to be relatively healthy people. Research model includes41 questionnaires, examination and blood plasma samples.Basic indexes of the body, cardiovascular system and respiratory functions were chosen by biomarkers,biological age is determined by V.P.Voytenko’s 4th version method and adaptive capacity assessment isdetermined by R.M.Baevskii’s multi-repeating regression method.Main skin type parameters such as porosity, wrinkles, pigmentation, elastics and aging is determined bythe “BOOMTECH skin diagnosis” digital equipment made in the Republic of Korea.The blood plasma MLT and EGF were measured by the method of ELISA analysis ELISA made in thelaboratory of the “AVITSENNA Science and Technology center”.The study material analysis carried out an analysis using logistic regression analysis and Pearson’scorrelation coefficient with SPSS 23.0 software.ResultThere’s an inverse weak correlation between blood plasma MLT and EGF with body wealth characteristicsof Uvs province citizens. It shows that when the blood plasma MLT and EGF decreases the body weight,body height and body weight index increase tendency.In women the decrease of blood plasma MLT and EGF also decreases the body height and body weightindex.Research on correlation between cardiovascular system and blood plasma MLT and EGF shows thatdecrease of blood plasma MLT causes in increased arterial pressures in both sexual groups, decreasedEGF in women causes decreased arterial pressure.Correlation study between skin main characteristics and blood plasma MLT and EGF shows thatdecreased blood plasma EGF in men resulted in decreased skin wrinkles, porosity, elasticity and skin aging index, in women decreased skin pigmentation and elasticity, and increased skin wrinkles, porosity and aging index in women.Research study of correlation between biological age and adaptive capacity assessment with the blood plasma MLT and EGF shows that decreased MLT and EGF in men results in increased biological age characteristics. In other words, the early aging is caused.The logistical regression analyses made using blood plasma melatonin, skin porosity, biological age,body height and sex as the risk parameters of Pearson coefficient and chi-squared parameter. Above model resulted in skin porosity and blood plasma MLT’s are becoming independent variable assessing the skin aging.Conclusions:1. The decreased MLT and EGF’s are resulted in increased body weight, body height and body weight index in men and decreased body height, body weight index in women.2. Decreased blood plasma MLT resulted in increased arterial pressure in both sexual groups and decreased EGF resulted in decreased arterial pressure in women.3. The decreased blood plasma MLT and EGF results in decreased skin wrinkles, porosity, elasticityand skin aging parameter with the increased skin pigmentation in men, as it results in decreasedskin pigmentation, elasticity and skin porosity parameters with the increased skin aging degree in women.4. When epidermal growth factor and blood plasma melatonin is decreased in men it results in increased biological age, but depends directly to the adaptive capacity assessment.5. Skin porosity and blood plasma melatonin were becoming independent variable to assess skin aging.
9.Comparison study of number of bones in human body of traditional and modern medicine
Tudevdagva L ; Bold Sh ; Tuul Kh ; Ariunjargal T ; Bat-Ochir M ; Bazarragchaa S ; Enkhjin G ; Duutbayr Kh
Mongolian Pharmacy and Pharmacology 2021;18(1):11-16
Background:
During the historical development of traditional medicine, many books and manuscripts have been written in Mongolian medicine. The main textbook of traditional medicine states that: “The size of a bone consists of 23 bone species, 28 spinal joints, 24 ribs, 32 teeth, and 360 pieces of bone.”
However, modern medicine estimates that the human body has 206 bones. Therefore, this topic was chosen to study the source material of traditional medicine, including the structure of the human body, and the number of bones in the modern medical anatomy textbook.
Purpose:
Details of the number of bones in the human body in the “Four Medical Tantras”
(རྒྱུད་བཞི) of traditional medicine and its commentary, as well as compare with the number of bones in the basic textbook of anatomy of modern medicine.
Objectives:
In order to successfully implement the research objectives, the following objectives will be implemented. These include:
1. Sampling and analyzing number of bones from traditional medicine;
2. Sampling and analyzing bone numbers from modern medical textbooks;
3. Compare the names and numbers of bones in traditional medicine and modern medicine
Results:
The number, classification and features of human bones were analyzed from the main scriptures of traditional medicine such as “Explanatory Tantra”, of the “Four Medical Tantras” and the “Legs bshad gser gyi thur ma” by Blo-bzang-chos-grags. In addition, the number of bones in the human body was sampled from modern medical textbooks and prepared for comparison. The number and characteristics of bones in the human body were compared by traditional medicine and modern medicine and made a conclusion.
This study reveals that the foundations for the integrated development of traditional medicine were laid long ago in Mongolian medicine. In addition, to highlight the book “Four Medical Tantras”, which is the basis of the textbook on the structure of the human body and the research work of scientists and scholars, which is considered in Mongolian mamba datsan’s contribution to the science of human anatomy. The importance of this research is to change the extremes of Western medicine and traditional medicine and increase opportunities to use its introduction and development into training and clinical practice.
Conclusion
1. The main creature of body structure in traditional medicine is the “Four Medical Tantras” which generally assumes that the numbers of bones are 360 but does not specify it in detail. During the research, we identified 357 bone names to identify each bone. The names and locations of the three bones were not clearly marked in the medical sources.
2. The numbers of bones are 206 in modern medical textbooks. We recalculated 151 bones based on traditional medical sources without duplication of that.
3. Compared to traditional medicine and modern medicine, the number of bones and are higher than 154 bone names in traditional medicine because we included the number of teeth, small bones in the ears and small bones in the fingers and toes. Some cartilage was also counted as bones.