1.Measurements of esophageal diseases and distribution
Gerelee G ; Tuul M ; Baikov V.V
Mongolian Medical Sciences 2011;172(2):8-16
Incidence rate of esophageal cancer is not similar in each country, for example higher incidence in Central Asia, North America and northern Africa. An esophageal cancer in Mongolia is 4th most common cancer after liver, stomach and lung cancers. At first to determine the structure and functional tendency we need to formulate mathematic analysis, processing and reference values of measurements. Formulation consists of 2 main parts that are quantitative and qualitative methods.Goal: By this research study we have aimed to determine pathological types and morphometric indices in esophageal cancer.Materials and Methods: Materials and samples for research study were chosen from biopsies, which were taken for diagnosis of esophageal disease in national center of cancer, Ulaanbaatar city among 1998-2002. These materials were diagnosed by international classification, 2006 of WHO. Totally 286 samples were prepared, here 184 (64.5%) samples were squamous cell carcinoma (well differentiated- 55, moderate differentiated-103, poorly differentiated-26), adenocarcinoma 20 (7%), undifferentiated carcinoma 7 (2.4%), intraepithelial neoplasia 74 (25.9%), low grade neoplasia 9 (3.1%) and high grade neoplasia was 65 (22.8%). Measurement was done by Video test 5.0 of Russia and software SPSS 17.0 was used for statistical analysis.Results: From the result of the study concluded the average indices are increased by 1.5 times in neoplasia cases of squamous epithelium, 2.1 times in well differentiated squamous cell carcinoma cases, 3.2 times in moderate differentiated squamous cell carcinoma cases, 2 times poorly differentiated squamous cell carcinoma cases, 2.1 times in adenocarcinoma cases and 1.7 times in the undifferentiated carcinoma cases in compare with relatively healthy average volume indices. But in the performed study was not observed a real difference between average volume indices of variable cancer cases. The most high rate of cell volume indices and square indices of nucleus were observed in moderate differentiated squamous cell carcinoma cases while in undifferentiated carcinoma and poorly differentiated squamous cell carcinoma cases were lowest rate of cell volume indices were observed.Conclusions: There are considerable signification on caryometrical and stereometrical research of differentiation between esophageal cancer and precancerous diseases.
2.A kinematic comparison of overground and treadmill walking
Batlkham D ; Munkh-Erdene B ; Tuul G
Mongolian Medical Sciences 2011;157(3):10-12
Introduction: Gait evaluation and training using treadmill will be increasingly used in near future. However it is con¬troversial whether the treadmill replicates the overground environment. Goal: Aim of this study was to compare overground and treadmill ambulation for possible differences in gait tempo¬ral variables and leg joint kinematics. Materials and Methods: A total of 10 participants walked on overground and treadmill. Participants walked at their preferred velocity on overground. The treadmill velocity was adjusted average velocity obtained in overground walking. Walking in two conditions was captured by high speed camera and analyzed by motion analyses software. Results: The maximum hip flexion angle (P=0.046), maximum hip extension (P=0.0001), maximum knee extension (P=0.0001) and maximum ankle dorsiflexion (P=0.022) were significantly different in the two conditions. Conclusions: The present study suggest that statistically significant differences exist between overground and treadmill walking in healthy subjects for some joint kinematic and temporal variables.
3.Result of stereometric research study of cardiomyocytes in cardiovascular diseases
Tuul G ; Odgerel TS ; Gerelee KH ; Batbayr KH ; Lhkaga L ; Zevgee T
Mongolian Medical Sciences 2011;172(2):27-32
In 2006, by the news of National Center of Health Development, morbidity of cardiovascular disease was 501.84 per 10000 people. It’s increased by 2 times than over 10 years.Goal: To study and to determine stereometric research, mathematic modeling and histologicalcharacteristic on cardiomyocyte of arterial hypertension (AH), acute myocardial infarction (AMI) and chronic rheumatoid fever (CRF).Materials and Methods: It was prepared sections for histometric materials from muscular of left ventricle. Linear measurement and number of cardiomyocyte per area of materials were carried out by computermicroscope “Leica” with program Diskus 3.2 version from German. On linear measurement of AH, AMI and CRF were processed by mathematic modeling. On ratio of cytoplasm and nucleus and histological characteristics were analyzed by chi-square testResults: Results of stereometric research on cardiomyocyte On AH volume of cardiomyocyte was 5788.22±40.99mkm3, volume of the nucleus - 806.47±12.86mkm3, ratio cytoplasm and nucleus 1:7 and number of cells per area was 10.On AMI volume of cardiomyocyte was 3240.94±48.96mkm3, volume of the nucleus - 693.85±12.76mkm3, ratio cytoplasm and nucleus 1:5 and number of cells per area was 16. On CRF volume of cardiomyocyte was 5341.06±63.4mkm3, volume of the nucleus - 801.5±15.96mkm3, ratio cytoplasm and nucleus 1:7 and number of cells per area was 11. In comparatively healthy condition at 20 to 30 years old population of Mongolia the volume of cardiomyocyte was determined 1063.17mkm3, volume of nucleus 406.69mkm3, ratio cytoplasm and nucleus 2.6 and number of cells per area was 31. Result of histological research of myocardial muscle. By the research of the difference between histological characteristic was confirmed that all of this characteristics have real main difference. Conclusions: It was confirmed difference with statistical probability by that determined volume of the cardiomyocyte 5788.22±40.99mkm3 in AH, 3240.94±48.96mkm3 in AMI and 5341.06±63.4mkm3 in CRF. Quantity of cells per area was in AH - 10, in AMI – 16 and in CRF 11, but in comparatively healthy condition it was 31.
4.The attack rates of the pandemic influenza infection, Ulaanbaatar, November 2009
Amarzaya S ; Altanchimeg S ; Suvd B ; Oyun M ; Enkhjargal T ; Tuul TS ; Dolgorkhand A ; Surenkhand G ; Ambeselmaa A
Mongolian Medical Sciences 2010;152(2):47-52
BACKGROUND: In Ulaanbaatar, the first case of the pandemic influenza infection has been reported on 12 October 2010.By November 9, a total of 929 cases laboratory-confirmed had been reported to National Center for CommunicableDiseases (NCCD). Of these cases reported, 9 people died.METHODS: The objectives of the study were to describe patients who admitted and hospitalized at NCCD and to determineoverall attack rates among health workers, secondary attack rates among students of colleges and universities. Datawas analyzed using Epi-Info2000.RESULTS: Among 929 of laboratory-confirmed cases, 50.3% (95% CI 43.0-57.5) were males aged 23 (±14.9) in averagewith youngest – 7 months, oldest – 76 years old. Data analysis by districts among the hospitalized patients, showed32.8% (139) of total cases in Bayanzurkh district including the first case of the pandemic influenza infection. The majorityof patients who admitted and hospitalized to NCCD mostly experienced fever (288, 68.1%), dry cough (251, 59.3%),headache (203, 48.0%), sore throat (175, 41.6%). With 1020 physicians and health workers in total, 41.4% (422) ofthem work at NCCD, 35.4% (361) – at MCHRC. 11.1% of health workers out of total become ill with pandemic H1N12009 (overall attack rate 11.1%) with the most common symptom, 380C and higher fever (100.0%, 113), sore throat(83.2%, 94), cough (76.1%, 86) and runny nose (59.3%, 67). The higher attack rates of health workers by occupationwere doctor (18.0%) and auxiliary (13%). The secondary attack rates among university students for influenza-likeillness(ILI) were 12.9%. These secondary attack rates were higher among students of art’s college as compared withother universities (52.4%). For students, the main clinical symptoms were fever + sore throat (75.0%, 18), fever+ cough(70.8%, 17).DISCUSSION: In China, as of 27 September, 2009, from reported total 19981 cases infected with pandemic influenza,61.0% were males, mean age was 17, mainly affected with 83% school students that consistent with our study result.The similar results on clinical symptoms were obtained in Russia. Out of 130 patients, 28.6% had 380Ñ and higherfever, for 54.3% the body temperature reached 38.1-390Ñ where as 17.1% - higher 390Ñ and 96% had cough, 89%had muscle ache, 65% had headache, 14% had diarrhea.
5.Study result of some treatment effects in collagen induced arthritis mouse model
Khongorzul B ; Bilguun E ; Undarmaa E ; Tuul B ; Gudegmaa TS ; Choijamts G ; Chimedtseren S
Mongolian Medical Sciences 2012;162(4):111-117
IntroductionRheumatoid Arthritis (RA) is chronic systemic inflammatory autoimmune disorder that still remains a disease of unknown etiology and complex disease without a single treatment that is dominated by serious and debilitating sequalae resulting from synovial membrane, cartilage and progressive joint destruction involvement. There is a one major obstacle in elucidating the early events in the pathogenesis of RA has been the lack of definition of the initial features of the disease. To overcome these difficulties, various animal models have been developed. But Collagen Induced Arthritis (CIA) mouse model is known to be the most valuable animal model to explore the pathogenic process, molecular and cellular mechanisms of joint destruction, to discover the immune system respond and activation and to develop new effective treatment methods and useful drugs [1].Materials and Methods:Within this study we have used 40 male mice at age 6-8 weeksfor 0-60 days and divided into following 4 groups which are:I group–CIA induced mouse group treated with Derveger Jirgeruu (Saposhnicovia divaricata) (n=12) II group–CIA induced mouse group treated with Natriisalicylas (10%) (n=12) III group–Healthy control mouse group (n=8) IV group–CIA inducedcontrol mouse group (n=8). To induce CIA model, we have used standard method of Murali /2005/’s design. Standard drug Natriisalicylas (10mg/ 20gr), one of the often used drug anti-inflammatory and Mongolian herbal plant Derveger jirgeruu (Saposhnicovia divaricate) (0.26mg/20gr) were daily administered by orally, starting on day 21 until day 60.To evaluate and compare 2 drug’s anti-inflammatory effect, we have done clinical score evaluation (Kim W.U, 2002), laboratory testing and histological examination of the joints using standard methods.ResultTo summarize the research result, both medications have proven to be as a medication which has anti-inflammatory effect that decreased the signs and symptoms of RA by it is histological and laboratory analysis.Conclusions:1. CIA model was effectively induced, which have proven by clinical signs, laboratory result and histological examination.2. Within this study it has proven that traditional herbal medicine Derveger Jirgeruu (Saposhnicovia divaricate) (0.26mg/20g) have anti-inflammatory effect on CIA induced mouse model of Rheumatoid Arthritis, which have had similar effect asstandard non-steroid medicine Natriisalicylas (10mg/20g).
6.Research on kidney disease in the scriptures
Gunjidmaa G ; Narkhand A ; Khaliunaa S ; Oyun-Erdene B ; Tuul Kh
Mongolian Pharmacy and Pharmacology 2022;21(2):23-26
Introduction:
Kidney disease is common in our country due to the four seasons and harsh climate. This article is discussed about the kidney health, causes, pathology and kidney on the relationship of other organs in traditional medicine.
Methods:
The study was processed using analysis and synthesis methods.
Results:
1. The root nature of the five vital organs are included in the yang character organs which hot nature qualities in five elements. However, some of the five vital organs will be under the influence of that place, as they will be located in the place of the “badgan”, in the place of the “mkhris”, and in the place of the “rlung”.
2. Kidney disease is usually caused by falling from a height, hit and injured, lifting heavy things, jogging and twisting your back uncomfortably, sit for a long time in a damp place, water events excess, eating too sweets that are heavy and cold qualities. In medical practice, kidney disease is accompanied by heart disease and liver disease.
Conclusion
In according to traditional medicine main theory, kidneys are a solid vital organ that generates heat and warms the lower body because of the high blood flow through its, on the other hand they are cold character which are in the place of the “rlung”. The kidneys are functionally closely related to other organs therefore, to get sick the effects of disease on other organs.
7.Comparison study of number of bones in human body of traditional and modern medicine
Tudevdagva L ; Bold Sh ; Tuul Kh ; Ariunjargal T ; Bat-Ochir M ; Bazarragchaa S ; Enkhjin G ; Duutbayr Kh
Mongolian Pharmacy and Pharmacology 2021;18(1):11-16
Background:
During the historical development of traditional medicine, many books and manuscripts have been written in Mongolian medicine. The main textbook of traditional medicine states that: “The size of a bone consists of 23 bone species, 28 spinal joints, 24 ribs, 32 teeth, and 360 pieces of bone.”
However, modern medicine estimates that the human body has 206 bones. Therefore, this topic was chosen to study the source material of traditional medicine, including the structure of the human body, and the number of bones in the modern medical anatomy textbook.
Purpose:
Details of the number of bones in the human body in the “Four Medical Tantras”
(རྒྱུད་བཞི) of traditional medicine and its commentary, as well as compare with the number of bones in the basic textbook of anatomy of modern medicine.
Objectives:
In order to successfully implement the research objectives, the following objectives will be implemented. These include:
1. Sampling and analyzing number of bones from traditional medicine;
2. Sampling and analyzing bone numbers from modern medical textbooks;
3. Compare the names and numbers of bones in traditional medicine and modern medicine
Results:
The number, classification and features of human bones were analyzed from the main scriptures of traditional medicine such as “Explanatory Tantra”, of the “Four Medical Tantras” and the “Legs bshad gser gyi thur ma” by Blo-bzang-chos-grags. In addition, the number of bones in the human body was sampled from modern medical textbooks and prepared for comparison. The number and characteristics of bones in the human body were compared by traditional medicine and modern medicine and made a conclusion.
This study reveals that the foundations for the integrated development of traditional medicine were laid long ago in Mongolian medicine. In addition, to highlight the book “Four Medical Tantras”, which is the basis of the textbook on the structure of the human body and the research work of scientists and scholars, which is considered in Mongolian mamba datsan’s contribution to the science of human anatomy. The importance of this research is to change the extremes of Western medicine and traditional medicine and increase opportunities to use its introduction and development into training and clinical practice.
Conclusion
1. The main creature of body structure in traditional medicine is the “Four Medical Tantras” which generally assumes that the numbers of bones are 360 but does not specify it in detail. During the research, we identified 357 bone names to identify each bone. The names and locations of the three bones were not clearly marked in the medical sources.
2. The numbers of bones are 206 in modern medical textbooks. We recalculated 151 bones based on traditional medical sources without duplication of that.
3. Compared to traditional medicine and modern medicine, the number of bones and are higher than 154 bone names in traditional medicine because we included the number of teeth, small bones in the ears and small bones in the fingers and toes. Some cartilage was also counted as bones.