Background: The Khongor soum has 253.3 thousand hectare square meter land which is 77 percent of Darkhan aimag from that 31.2 thousand hectare square meter land is used for plantation purpose. 12% of population is kazak. In April 2007, environment and drinking water resource of Khongor soum was polluted by dilution sewage water. Since after this incidence population were complaining about health status. Purpose of this survey was to determine cancer and general mortality of soum population. There 2 objectives: 1. To verify cancer mortality and morbidity in Khongor soum, Darkhan2. To assess excess mortality of cancer in the Khongor soumMethods: Health secondary data of 2006-2009 of Health department of Darkhan-Uul aimag was used for the assessment. The information about cause of death, number of death, population and so on were collected to caluculate crude mortality and cancer-specific mortality.Results: in 2007, the lowest or 4950 population was registered in Khongor soum and the highest number or 5628 of population was registered in 2002. The number of population gradually increased in 2009 by 5603. During 2006-2009 66 people were died in Khongor soum and this means 125.3 populations per 10000. According to the year trend mortality (66) rate was not fluctuated year by year. The leading ten causes of mortality of Khongor soum, at the first CVD (51.1 per 10000) and at the second cancer (37.8 per 10000) and it is similar with Mongolian mortality consistence. According to standardized mortality rate, mortality of Darkhan-Uul aimag was 8 per 10000 and the level of Khongor soum was 0.3 which means less than state average level. During 2006-2009 years, 24 people were died due to cancer and most of them were male (17, 70.8%). Every year of surveyed time, male mortality rate was high. The registered cancer (62.5 per 10000) of soum was similar with state average level and 1.5 times less then Darkhan- Uul aimag (92.5 per 1000) level.Conclusions: The last 5 years mortality rate of Khongor soum (124.9 per 10000) less 2.4 times from Mongolian state average level and 1.9 times less than Darkhan-uul aimag level. There are approved that cancer level of Khongor soum was not increased in last year. However, it is recommended to monitor Khongor soum’s morbidity and mortality to evaluate long-term effect of environmental pollution.

1.Changes in microorganism’s quantity or activity can precede detectable changes in soil chemical properties, thereby providing an early sign of soil improvement or early warning soil degradation.2.Erdenet mining factory soil has approsintly 0.59*106 cell/g and control soil has 1.17*106 cell/g. Herein bacteria were 57%, actinomycete 31% and fungi 12%. But control soil bacteria were 83%, actinomycete 16% and fungi 1%.3.We have chosen deferent by morphology separate 29 cleanly cultures. In tolerance of heave metal, cultures which extracted from 1415 m level is tolerant against 6 mM of Fe, 5 mM of Pb, 3 mM of Mo and Cu, 1 mM of Cr

Within the spectrum of diagnostic procedures in hepatology, the procurement of a liver specimen plays an important role. The method has been diversifi ed to encompass not only different needle types for cutting and aspiration but also different routes proceeding transvenously or transcutaneously. Over the subsequent 50 years the technique of obtaining liver biopsy samples has been modifi ed regarding the approach, the needle type, and the combination with diagnostic imaging techniques such as ultrasound, computed tomography, angiography and laparoscopy. Histological analyses are capable of establishing the etiology of a chronic or acute liver disease, are determined the inflammatory activity (Grading), degree of fi brosis/cirrhosis (Staging), are relevant for the prognosis of the patient and for indication for cost-intensive as well as potentially side are effect-prone therapies. In general, the accepted mortality rate from liver biopsy is between 0,1% and 0,01%. Among the most feared complications of liver biopsies are hemorrhage, seeding of cancer cells, infections, and injury to the viscera. The increasing number of liver transplant patients within the hepatological spectrum requires regular, safe, and high quality biopsies and their appropriate.

Thyroid nodular lesions are the common clinical problem in the world. A variety of tests have been employed to separate benign from malignant thyroid nodules. These tests include isotope scanning and fine needle aspiration cytology (FNAC). Our research was based on the fact that the comparison of FNAC and thyroid isotope scan in thyroid nodule was not researched in Mongolia. Therefore, we want to evaluate the specimen adequacy of FNAC, and compare its result to thyroid isotope scanning in patients with thyroid nodule. The research was conducted on archive materials of FNAC and thyroid isotope scanning of patients with thyroid nodule who were treated in surgical department of The First Central Hospital from 2012 to 2015, and the statistic analyze was done by using SPSS 20 under the auspices of School of Pharmacy and Bio-Medicine,Department of pathology, Mongolian National University of Medical Sciences. We have collected the FNAC of 807 patients, including 34 patients (4.2%) were males and 773 patients (95.8%) were females. FNA cytology results were interpreted as benign in 495 cases (61.3%), follicular lesion of undetermined significance in 31 cases (3.8%), follicular neoplasm in 9 cases (1.1%) suspicious in 17 cases (2.1%), malignant in 3 cases (0.4%), and unsatisfactory in 252 cases (31%). We have got the result of thyroid isotope scanning of 43 (5.32%) patients out of 807 cases. On thyroid scan, 18 patients (41.9%) having cold nodule were labeled as suspicious for malignancy, 25 patients (58.1%) had hot nodule. The FNA diagnosis of 25 patients with a hot nodule following: 1 patient (4%) with neoplasm, 17 patients (68%) with benign results, 6 patients (24%) had non-diagnostic. The FNA diagnosis of 18 patients (41.9%) with cold nodule following: 1 patient (5.5%) with follicular lesion of undetermined significance, 10 patient (55.5%) with benign, 5 patient (27.7%) with non-diagnostic, 2 patient (11.1%) had malignant. The FNAC results were interpreted as benign in 495 cases (61.3%), malignant in 3 cases (0.4%), and unsatisfactory in 252 cases (31%). Two patients out of 18 patients with cold nodule diagnosed as malignancy by FNAC. The sensitivity and specificity of thyroid isotope scanning was 96% and 16.6%, respectively.

Introduction: According to the 5th National Nutrition Survey, 6.1 percent of all children were stunted and 1.4 percent had severe stunts. Stunts are a manifestation of chronic nutrition disorders caused by repeated and chronic diseases, not having adequate nutrition for a long time.
The National Nutrition Survey, published in the National I-V study, assesses the nutritional status of under-five children. However, studies on nutritional, nutrient, and safety in children are not yet available. Therefore, it is necessary to study the nutritional and nutritional qualities of children in kindergartens. Goal: To evaluate the nutrition of children in the kindergarten, calories and nutrients, and evaluate whether they meet the established norms. Material and Method: The survey covered 96 kindergartens. Survey data based on food expenditure report of kindergarten, were processed by Microsoft Excel. Calories and nutrients are calculated by calculation method. Results: The use of milk and dairy products for children in kindergartens was 1.1-1.8 times, flour product consumption was 1.5 times, vegetable consumption was 1.7 times, fruit consumption was 4.1 times lower than the approved recommendations.
The consumption of meat and meat products for children was 1.2 times, rice consumption was 1.6 times, sugar and sweet products was 1.4 times higher than the approved recommendations.
The number of protein for children in kindergartens is 1.2, fat is 1.1, carbohydrate is 1.3 times less, and feeds averaging 1038.6 kcal per day, which is 310.6 kcal less than the approved recommendation. Conclusion Kindergarten children cannot get sufficient quantities of milk, dairy products, fruits The amount of meat, flour, rice, and sweet foods for children of the kindergarten is greater than the recommended size.
The calorie of diet for children in kindergarten is less than 310 calories from the recommended level

Introduction: Gait evaluation and training using treadmill will be increasingly used in near future. However it is con¬troversial whether the treadmill replicates the overground environment. Goal: Aim of this study was to compare overground and treadmill ambulation for possible differences in gait tempo¬ral variables and leg joint kinematics. Materials and Methods: A total of 10 participants walked on overground and treadmill. Participants walked at their preferred velocity on overground. The treadmill velocity was adjusted average velocity obtained in overground walking. Walking in two conditions was captured by high speed camera and analyzed by motion analyses software. Results: The maximum hip flexion angle (P=0.046), maximum hip extension (P=0.0001), maximum knee extension (P=0.0001) and maximum ankle dorsiflexion (P=0.022) were significantly different in the two conditions. Conclusions: The present study suggest that statistically significant differences exist between overground and treadmill walking in healthy subjects for some joint kinematic and temporal variables.

Background: Research of histo and cytometry in comparative healthy and pathological condition is not so much in our country. Therefore, it is making a demand to do stereometrical research study on tissues, cells and nucleus.Goal: To study and to determine stereometrical indices, mathematic model of hepatocytes and nucleus in condition of comparatively healthy, acute intoxication, chronic inflammation and cancer of Mongolians.Materials and Methods: It was prepared sections for histometric materials. Linear measurements of hepatocytes and nucleus were carried out by computer-microscope “Leica” with program Diskus 3.2 version from German. On linear measurement in condition of comparatively healthy, acute intoxication, chronic inflammation and cancer were processed by mathematic modeling.Results: Volume distribution of hepatocyte’s cytoplasm χ2st=15.51>χ2 F=4.31; (P<0.001), and hepatocyte’s nucleus χ2 st=12.59>χ2 F=10.74 in comparatively healthy (normal) conditions pursues normal distribution formula, however, the volume of hepatocyte’s cytoplasm and nucleus follows Maxwell formula of abnormal distribution χ2 st=23.68>χ2 F=10.44; (P<0.001), χ2 st=15.51>χ2 F=6.90; (P<0.001) in a condition of acute intoxication and volume of hepatocyte’s cytoplasm and nucleus χ2 st=23.68>χ2 F=8.03; (P<0.001), χ2 st=15.51>χ2 F=4.32; (P<0.001) in a condition of chronic inflammation. And volume distribution of hepatocyte’s cytoplasm χ2 st=8.27>χ2F=19.68; (P<0.001), and hepatocyte’s nucleus χ2st=3.41>χ2F=3.82 incondition of cancer. There is no statistically significant difference (P<0.001) between observation and theoretical frequencies of average values of hepatocyte’s cytoplasm and nucleus volume, which confirms that the result is true and accurate.Conclusions:1. Volume of hepatocyte’s cytoplasm is 2184.18±36.98 mkm3 in comparatively healthy (normal) conditions, 4153.17±84.18 mkm3 in a condition of acute intoxication, 4887.84±75.51 mkm3 in a condition of chronic inflammation and 13143.88±4.29 mkm3 in a cancer condition. Volume of nucleus is 299.94±36.98 mkm3 in comparatively healthy (normal) conditions, 873.59±13.86 mkm3 in a condition of acute intoxication, 888.65±13.51 mkm3 in a condition of chronic inflammation and 2924.57±2.12 mkm3 in a cancer condition.2. Volume of hepatocyte’s cytoplasm was increased 2 times, volume of hepatocyte’s nucleus was increased 3 times in a condition of acute intoxication and volume of hepatocyte’s cytoplasm was increased 2.2 times, volume of hepatocyte’s nucleus was increased 2.9 times (P< 0.001) in a condition of chronic inflammation. However volume of hepatocyte’s cytoplasm was increased 6.5 times, volume of hepatocyte’s nucleus was increased 9.7 times in a condition of cancer.

Bacground: Liver cancer is the 5th most common cancer worldwide with 500,000 cases diagnosed per year. It is a disease with a high death rate (14000-15000 per year). By the last news of national center of health development, liver cancer is first most common cancer in our country. Goal: To study and to compare volumetric modeling of hepatocyte’s cytoplasm, nucleus and stereometric indices in condition of comparatively healthy, acute intoxication, chronic inflammation, cancerous condition and clear cell tumor, and to explain by non linear theory.Materials and Methods: It was prepared sections for histometric materials. Linear measurements of hepatocytes and nucleus were carried out by computer microscope ‘Leica’ with program Diskus 3.2 version from GermanOn linear measurement in condition of comparatively healthy, acute intoxication, chronic inflammation, cancerous condition and clear cell tumor were processed by mathematic modeling. Results: In comparatively healthy condition the volume of the hepatocyte’s cytoplasm was determined 2140.73±19.97 mkm3, the volume of the hepatocyte’s nucleus was 295.19±2.60 mkm3, ration between hepatocyte’s cytoplasm and nucleus was 7:1 (P<0.001). In condition of acute intoxication the volume of the hepatocyte’s cytoplasm was determined 4281.36±77.83 mkm3, the volume of the hepatocyte’s nucleus was 895.00±13.42 mkm3, ratio between hepatocyte’s cytoplasm and nucleus was 5:1 (P<0.001). In condition of chronic inflammation the volume of the hepatocyte’s cytoplasm was determined 4887.84±75.72 mkm3, the volume of the hepatocyte’s nucleus was 888.65±12.46 mkm3, ration between hepatocyte’s cytoplasm and nucleus was 5:1 (P<0.001). In cancerous condition the volume of the hepatocyte’s cytoplasm was determined 3852.63±116.06 mkm3, the volume of the hepatocyte’s nucleus was 463.09±12.95 mkm3, ratio between hepatocyte’s cytoplasm and nucleus was 8:1 (P<0.001). In clear cell tumor the volume of the hepatocyte’s cytoplasm was determined 15062.69±348.41 mkm3, the volume of the hepatocyte’s nucleus was 801.05±22.56 mkm3, ratio between hepatocyte’s cytoplasm and nucleus was 19:1 (P<0.001). Conclusions:1. We have determined volume of hepatocyte’s volume and nucleus, ratio between cytoplasm and nucleus in condition of comparatively healthy, acute intoxication, chronic inflammation, cancerous and clear cell tumor.2. Volume of hepatocyte’s cytoplasm was increased 2.28 times, volume of hepotocyte’s nucleus was increased 3.01 times in condition of chronic inflammation and volume of hepatocyte’s cytoplasm was increased 1.99 times, volume of hepotocyte’s nucleus was increased 3.03 times in condition of acute intoxication. Also volume of hepatocyte’s cytoplasm was increased 1.79 times, volume of hepotocyte’s nucleus was increased 1.5 times in cancerous condition and volume of hepatocyte’s cytoplasm was increased 7.03 times, volume of hepotocyte’s nucleus was increased 2.7 times in condition of clear cell tumor.3. By the comparison between volumes of hepatocyte’s cytoplasm and nucleus in condition of comparatively healthy, acute intoxication, chronic inflammation, cancerous was determined medium direct correlation rather by the comparison between volumes of hepatocyte’s cytoplasm and nucleus in condition of clear cell tumor wasn’t determined correlation.

Background: The intraoperative smear cytology (squash preparation) is fairly accurate, simple, reliabletool for rapid intraoperative diagnosis of neurosurgical biopsies [1]. In the early 1930s, Dr Eisenhardtand Cushing introduced intraoperative cytological investigations for rapid examination of neurosurgicalspecimens and guidance of surgical treatment [2]. Besides rapid decision making during neurosurgicalprocedures, it is also to be ensured that minimum injury is caused to the normal brain structuressurrounding the intracranial neoplasm. It has become necessary for pathologists to train themselves inthe interpretation of cytomorphological features of various central nervous system lesion and used inmany neurosurgical units of all over the world [3]. Thus, to begin doing intraoperative squash cytology inour practice is the aim of this study.Aim: To study the diagnostic accuracy of squash cytology in the intraoperative diagnosis of centralnervous system tumorsMaterials and Methods: The material for this study was obtained from 30 cases of nervous systemneoplasms sent for intraoperative consultation from State Third Central Hospital, Shashtin to the thirdsection of National Center for Pathology between 7th of November 2013 to 28th of March 2014. Squashpreparation was performed on all cases and stained with hematoxylin and eosin. The diagnosis given onsquash cytology was then compared with final diagnosis given on paraffin-embedded sections.Results: Of total 30 cases of primary central nervous system tumors, neuroepithelial tumors are thelargest category of tumors (50%). The accuracy of squash cytology was 82.1%.Conclusion: This is the first study in our country where intra-operative squash cytology in brain tumorwas done and diagnostic accuracy was 82.1% as very good category. There were 4 cases had diagnosticdiscrepancy.

Background: Discrepancies in the sensitivity to biological effects of the androgens, exerted through the binding of the hormone to the androgen receptor (AR), may also be involved in the inter-individual variation of T as well as in age related decline. The human androgen receptor (AR), located on chromosome Xq11-12, is a transcription factor regulating the development of male reproductive organs in the fetus and secondary sex characteristics at puberty in response to testosterone (T) and 5a-dihydrotestosterone (DHT). The AR contains two polymorphic regions, the (CAG)nCAA repeat encoding polyglutamine, and the (GGT)3GGG(GGT)2(GGC)n repeat encoding polyglycine, commonly referred to as the CAG and GGN repeats respectively. The aim of this study is to investigate the effect of the human androgen receptor genes CAG and GGN repeat polymorphisms in relation with androgen level.Materials and Methods: Sample collection: 180 male, the medical data of these volunteers were obtained and determined some androgen hormones at first phase of study in 2010-2011 (total testosterone (TT), free testosterone (FT) and bioavailable testosterone (BAT)). To determine CAG/GGN repeats length in exon of androgen receptor gene, using frozen serum as a source of deoxyribonucleic acid (DNA). DNA was extracted from blood samples (200 ml) using High PurePCR Template Preparation Kits.Results: The 180 men whose age is at least 40 were involved in our research and their average age was 55.1±10.3. The 46.7% (84) of the participants presents CAG gene, the 6.1% (11) of the participants presents GGN gene while the 25.5% (46) of the participants presents both CAG and GGN genes. However, the 21.7% of 39 men not presents CAG and GGN genes.Conclusion: The free testosterone level was significantly decreasing with aging. However, the appearance of CAG gene polymorphism was significantly higher in more aged people. Decline of free testosterone level in participants with CAG and [CAG+GGN] combined form was stronger than in people with GGN gene polymorphism and CAG, GGN both undetected people. But the level of bioavailable testosterone was decreasing with aging and the appearance of CAG gene polymorphism (r=-0.425, p=0.01) and [CAG+GGN] combined form (r=-0.491, p=0.028) was also increasing.