1.Radiation Exposure to Premature Infants in a Neonatal Intensive Care Unit in Turkey.
Turan OLGAR ; Esra ONAL ; Dogan BOR ; Nurullah OKUMUS ; Yildiz ATALAY ; Canan TURKYILMAZ ; Ebru ERGENEKON ; Esin KOC
Korean Journal of Radiology 2008;9(5):416-419
OBJECTIVE: The aim of this work was to determine the radiation dose received by infants from radiographic exposure and the contribution from scatter radiation due to radiographic exposure of other infants in the same room. MATERIALS AND METHODS: We retrospectively evaluated the entrance skin doses (ESDs) and effective doses of 23 infants with a gestational age as low as 28 weeks. ESDs were determined from tube output measurements (ESD(TO)) (n = 23) and from the use of thermoluminescent dosimetry (ESD(TLD)) (n = 16). Scattered radiation was evaluated using a 5 cm Perspex phantom. Effective doses were estimated from ESD(TO) by Monte Carlo computed software and radiation risks were estimated from the effective dose. ESD(TO) and ESD(TLD) were correlated using linear regression analysis. RESULTS: The mean ESD(TO) for the chest and abdomen were 67 micro Gy and 65 micro Gy per procedure, respectively. The mean ESD(TLD) per radiograph was 70 micro Gy. The measured scattered radiation range at a 2 m distance from the neonatal intensive care unit (NICU) was (11-17 micro Gy[corrected to 11-17 nGy]) per radiograph. Mean effective doses were 16 and 27 micro Sv per procedure for the chest and abdomen, respectively. ESD(TLD) was well correlated with ESD(TO) obtained from the total chest and abdomen radiographs for each infant (R2 = 0.86). The radiation risks for childhood cancer estimated from the effective dose were 0.4 x 10(-6) to 2 x 10(-6) and 0.6 x 10(-6) to 2.9 x 10(-6) for chest and abdomen radiographs, respectively. CONCLUSION: The results of our study show that neonates received acceptable doses from common radiological examinations. Although the contribution of scatter radiation to the neonatal dose is low, considering the sensitivity of the neonates to radiation, further protective action was performed by increasing the distance of the infants from each other.
Female
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Humans
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Infant, Newborn
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*Infant, Premature
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*Intensive Care, Neonatal
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Linear Models
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Male
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Monte Carlo Method
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*Radiation Dosage
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Radiography, Abdominal
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Radiography, Thoracic
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Retrospective Studies
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Risk Assessment
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Risk Factors
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Thermoluminescent Dosimetry
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Turkey
2.Erratum.
Turan OLAR ; Esra ONAL ; Dogan BOR ; Nurullah OKUMUS ; Yildiz ATALAY ; Canan TURKYILMAZ ; Ebru ERGENEKON ; Esin KOC
Korean Journal of Radiology 2010;11(1):131-131
The radiation dose unit for the scattered radiation in the following sentence, "The measured scattered radiation range at a 2 m distance from the NICU was 11-17 micro Gy per radiograph." passed in the abstract results section and main results section of the Korean J Radiol 2008;9:416-419 should be replaced as 11-17 nGy
3.Decreased Expression of α-Synuclein, Nogo-A and UCH-L1 in Patients with Schizophrenia: A Preliminary Serum Study.
Ömer Faruk DEMIREL ; İhsan CETIN ; Şenol TURAN ; Tarık SAĞLAM ; Nazım YILDIZ ; Alaattin DURAN
Psychiatry Investigation 2017;14(3):344-349
OBJECTIVE: α-synuclein, Nogo-A and Ubiquitin C-terminal hydrolase L1 (UCH-L1) have neuromodulatory roles for human brain. Therefore, abnormalities of these molecules are associated with neuropsychiatric disorders. Although some serum studies in the other disorders have been made, serum study of α-synuclein, Nogo-A and UCH-L1 is not present in patients with schizophrenia and healthy controls. Therefore, our aim was to compare serum levels of α-synuclein, Nogo-A and UCH-L1 of the patients with schizophrenia and healthy controls. METHODS: Forty-four patients with schizophrenia who is followed by psychotic disorders unit, and 40 healthy control were included in this study. Socio-demographic form and Positive and Negative Syndrome Scale (PANSS) was applied to patients, and sociodemographic form was applied to control group. Fasting bloods were collected and the serum levels of α-synuclein, Nogo-A and UCH-L1 were measured by ELISA method. RESULTS: Serum α-synuclein [patient: 12.73 (5.18–31.84) ng/mL; control: 41.77 (15.12–66.98) ng/mL], Nogo-A [patient: 33.58 (3.09–77.26) ng/mL; control: 286.05 (136.56–346.82) ng/mL] and UCH-L1 [patient: 5.26 (1.64–10.87) ng/mL; control: 20.48 (11.01–20.81) ng/mL] levels of the patients with schizophrenia were significianly lower than healthy controls (p<0.001). CONCLUSION: Our study results added new evidence for explaining the etiopathogenesis of schizophrenia on the basis of neurochemical markers.
Biomarkers
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Brain
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Enzyme-Linked Immunosorbent Assay
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Fasting
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Humans
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Methods
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Psychotic Disorders
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Schizophrenia*
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Ubiquitin Thiolesterase
4.Müller Muscle-conjunctival Resection with or without Tarsectomy and Combined with Bandage Contact Lens Use in Ptosis Patients with Corneal Graft
Mehmet Serhat MANGAN ; Serap Yurttaser OCAK ; Ece Turan VURAL ; Elvin YILDIZ
Korean Journal of Ophthalmology 2021;35(1):10-17
Purpose:
To examine the efficacy of ptosis correction with a Müller muscle-conjunctival resection with or without tarsectomy (MMCR±T), combined with bandage contact lens (BCL) use, in corneal graft patients.
Methods:
Seven patients with corneal grafts who underwent MMCR±T for treatment of ptosis were evaluated retrospectively. A BCL was applied to the grafts at the end of the surgery. The collected data included preoperative and postoperative visual acuity, marginal reflex distance 1 (MRD-1), presence of Hering’s dependency by the phenylephrine test, symmetry outcomes, and complications after MMCR±T.
Results:
The average duration between the penetrating keratoplasty and MMCR±T was 14 months, with a follow-up time of 10.4 months after MMCR±T. Hering’s dependency was observed in four (57.2%) patients before MMCR±T, and MRD-1 was increased in all patients based on preoperative phenylephrine tests. The mean preoperative MRD-1 was -0.14 ± 0.55 mm, and the mean postoperative MRD-1 was 2.35 ± 0.89 mm (p < 0.0001). Symmetry outcomes of perfect (<0.5 mm), good (0.5–1 mm), and fair (≥1 mm) were noted after MMCR±T in three, three, and one patients, respectively. During the follow-up, no obvious corneal epitheliopathy, keratitis, or corneal graft rejection/failure were noted in any cases. BCL use was well tolerated by all patients.
Conclusions
Most patients achieved good surgical outcomes with the application of the BCL to protect the graft and with the use of the phenylephrine test and Hering’s dependency to predict the final eyelid position and symmetry. MMCR±T combined with BCL may therefore represent an alternative approach for correction of ptosis in patients with corneal graft.
5.Glial Cell Line-Derived Neurotrophic Factor, S-100 Protein and Synaptophysin Expression in Biliary Atresia Gallbladder Tissue
Semra GÜRÜNLÜOĞLU ; Canan CERAN ; Kubilay GÜRÜNLÜOĞLU ; Alper KOÇBIYIK ; Mehmet GÜL ; Turan YILDIZ ; Harika Gözükara BAĞ ; Semir GÜL ; Aytaç TAŞÇI ; Ercan BAYRAKÇI ; Necmettin AKPINAR ; Ecem Serbest ÇIN ; Hasan ATEŞ ; Mehmet DEMIRCAN
Pediatric Gastroenterology, Hepatology & Nutrition 2021;24(2):173-186
Purpose:
Biliary atresia (BA) is a disease that manifests as jaundice after birth and leads to progressive destruction of the ductal system in the liver. The aim of this study was to investigate histopathological changes and immunohistochemically examine the expression of glial cell line-derived neurotrophic factor (GDNF), synaptophysin, and S-100 protein in the gallbladder of BA patients.
Methods:
The study included a BA group of 29 patients and a control group of 41 children with cholecystectomy. Gallbladder tissue removed during surgery was obtained and examined immunohistochemically and histopathologically. Tissue samples of both groups were immunohistochemically assessed in terms of GDNF, S-100 protein, and synaptophysin expression. Expression was classified as present or absent. Inflammatory activity assessment with hematoxylin and eosin staining and fibrosis assessment with Masson's trichrome staining were performed for tissue sample sections of both groups.
Results:
Ganglion cells were not present in gallbladder tissue samples of the BA group.Immunohistochemically, GDNF, synaptophysin, and S-100 expression was not detected in the BA group. Histopathological examination revealed more frequent fibrosis and slightly higher inflammatory activity in the BA than in the control group.
Conclusion
We speculate that GDNF expression will no longer continue in this region, when the damage caused by inflammation of the extrahepatic bile ducts reaches a critical threshold. The study's findings may represent a missing link in the chain of events forming the etiology of BA and may be helpful in its diagnosis.
6.Glial Cell Line-Derived Neurotrophic Factor, S-100 Protein and Synaptophysin Expression in Biliary Atresia Gallbladder Tissue
Semra GÜRÜNLÜOĞLU ; Canan CERAN ; Kubilay GÜRÜNLÜOĞLU ; Alper KOÇBIYIK ; Mehmet GÜL ; Turan YILDIZ ; Harika Gözükara BAĞ ; Semir GÜL ; Aytaç TAŞÇI ; Ercan BAYRAKÇI ; Necmettin AKPINAR ; Ecem Serbest ÇIN ; Hasan ATEŞ ; Mehmet DEMIRCAN
Pediatric Gastroenterology, Hepatology & Nutrition 2021;24(2):173-186
Purpose:
Biliary atresia (BA) is a disease that manifests as jaundice after birth and leads to progressive destruction of the ductal system in the liver. The aim of this study was to investigate histopathological changes and immunohistochemically examine the expression of glial cell line-derived neurotrophic factor (GDNF), synaptophysin, and S-100 protein in the gallbladder of BA patients.
Methods:
The study included a BA group of 29 patients and a control group of 41 children with cholecystectomy. Gallbladder tissue removed during surgery was obtained and examined immunohistochemically and histopathologically. Tissue samples of both groups were immunohistochemically assessed in terms of GDNF, S-100 protein, and synaptophysin expression. Expression was classified as present or absent. Inflammatory activity assessment with hematoxylin and eosin staining and fibrosis assessment with Masson's trichrome staining were performed for tissue sample sections of both groups.
Results:
Ganglion cells were not present in gallbladder tissue samples of the BA group.Immunohistochemically, GDNF, synaptophysin, and S-100 expression was not detected in the BA group. Histopathological examination revealed more frequent fibrosis and slightly higher inflammatory activity in the BA than in the control group.
Conclusion
We speculate that GDNF expression will no longer continue in this region, when the damage caused by inflammation of the extrahepatic bile ducts reaches a critical threshold. The study's findings may represent a missing link in the chain of events forming the etiology of BA and may be helpful in its diagnosis.