Objective To explore the clinical value of combined detection of serum carbohydrate antigen 724 (CA724),carcinoembryonic antigen (CEA),and tumor necrosis factor-α (TNF-α) for the diagnosis,assessment of curative effect,and illness monitoring for advanced gastric cancer (AGC).Methods Serum levels of CA724,CEA and TNF-α were measured by the methods of chemiluminescence and compared in 20 patients with AGC (Group A),20 patients with benign gastric disease (Group B),and 20 healthy adults (Group C).Also,serum levels of CA724,CEA and TNF-α in peripheral blood as well as in portal vein were measured and compared before and after surgical treatment in patients of group A.Results The serum levels of CA724,CEA and TNF-α in patients of group A were significantly higher than groups B and C (P ＜ 0.05).In addition,the serum levels of CA724,CEA and TNF-α in patients of group A were decreased after surgical treatment and increased slightly after one month (P ＜ 0.05).Conclusions The serum levels of CA724,CEA and TNF-α in most patients of AGC are significantly elevated and the combined detection of serum CA724,CEA and TNF-α contributes to the diagnosis,assessment of curative effect,and illness monitoring for AGC.

Objective: To investigate the clinicopatholigical differences between patients with adenocarcinoma of esophagogastric junction (AEG) and gastric cancer without esophagogastric junction invasion, and relationship between the two type cancers and Helicobacter pylori (Hp) infection, body mass index. Methods: A retrospective analysis was performed on 577 cases of gastric cancer patientsin the Third Hospital of Mianyang from December 2013 to February 2018.Patients were divided into AEG group (n=218) and gastric cancer without esophagogastric junction invasion group (n=359) according to location of neoplasm. The age, gender, body mass index, Hp infection, pathological stage, operative type and blood loss in operation of patients between two groups were compared, and the relationship between the two type cancers and Hp infection, body mass index was analyzed by logistic regression, OR and 95%CI: was calculated. Results: AEG patients were accounted for 37.8%, and had a relatively higher percentage of males, older age, more open surgery, surgery duration and perioperative transfusion, and a relatively lower percentage of Hp infection and family history of gastric cancers. When adjusted for age, gender and family history, the frequency of infection with Hp was higher in patients with gastric cancer without esophagogastric junction invasion, the OR was 1.73(95%CI: 1.22-2.46, P<0.05), while the differences of BMI was not significant between patents in two groups. Conclusion The different characteristics of AEG and gastric cancer without esophagogastric junction invasion cases have implications for the development of guiding strategies for diagnosis and treatment of gastric cancer patients based on tumor location.