Objective To enrich the control ways of Sickbed Calling System. Except for real time communication between sickrooms and the nursing station, situations in every sickroom are excepted to be learned conveniently, thus realizing scientific sickroom management of the hospital. Methods The Calling System of Sickbed was designed by using programmable controller instead of singlechip control system. Results The experiment demonstrated that the Sickbed Calling System designed by programmable controller was simpler and more popular. Conclusion Calling System of Sickbed designed by programmable controller can realize the management of Sickbed Calling System promptly and accurately. It has a bright application future.

Objective To explore the effect of different doses of anthracycline on preoperative chemotherapy of breast cancer.Methods In 40 cases of breast cancer patients using small doses of anthracycline therapy, and classified as the control group, the other 40 patients using high-dose anthracycline therapy, and classified as observation group.Then observe two groups of patients were compared;the patients were in our hospital from January to December 2016 were treated.Results The total effective rate was 82.5% in the observation group and 62.5% in the control group, the difference between the two groups was statistically significant (P<0.05).The incidence of adverse reactions in the observation group was 0, the control group was 27.5%, and the incidence of adverse reactions in the two groups was statistically significant (P<0.05).Conclusion Different doses of anthracyclines on the clinical effect of chemotherapy before surgery for breast cancer research found that different the clinical effect of different doses produced by E100C and E75C, E100C can improve the treatment effect of the patients, and reduce the occurrence of toxicity, so it is worthy of reference.

Alzheimer disease (AD) is the most common form of dementia in aged population; it is a neurodegenerative disorder with unknown etiology and pathogenesis. The major pathological findings of AD include senile plaques, neurofibrillay tangles, and apoptosis-related regional synaptic and neuronal degeneration. The brain senile plaques are mainly produced by β-amyloid, a peptide with neurotoxicity and vasculotoxicity. Due to the polygenic and heterogeneous characteristics of AD, Amyloid Cascaded Hypothesis is currently drawing increasingly more attention. This paper reviews the relation between Aβ and AD published recently.

Marburg virus (MARV) is a member of the Filoviridae family and belongs to a non-segmented, single-strand and negative-sense RNA virus.Since the first discovery of virus in 1967, infections have broken out 14 times, causing the infection of 588 people and 482 deaths.The mortality is up to 82%.Marburg virus results in multiple organ infections , severe hemorrhagic fever and death .Currently, there are no available licensed vaccines or post-exposure treatment , but the vaccines have proved effective in experimental animals .This review briefly summarizes the structure , infection mechanism and the progress in vaccines of this virus .

Objectives To study application efficiencies of two types of intestinal ostomy in the treatment of elderly patients with obstructive sigmoid colon cancer and colorectal cancer.Methods 62 elderly patients with obstructive sigmoid colon cancer and rectal cancer from January 2013 to January 2016 in our hospital were chosen.The patients were divided into loop ileostomy group(n=32) and colostomy group(n=30)depending on the type of therapy.And the stage Ⅰ and Ⅱ operative time,hospital stay,postoperative fasting time and postoperative complication incidence rates were compared between the two groups.Results The postoperative fasting time was significantly shorter in loop ileostomy group than in colostomy group during stage Ⅰ surgery(2.5 ± 0.5)d vs.(4.6 ± 0.6)d(t=14.3644,P =0.0000).In stage Ⅱ surgery,the operative time,hospital stay,postoperative fasting time (2.9 ± 0.6)d vs.(4.9 ± 0.4)d,(1.4 ± 0.4)d vs.(2.5 ±± 0.3)d,(6.3± 1.4d)vs.(8.8±1.2)d were significantly lower in the loop ileostomy group than in the colostomy group(t=-15.2762、-10.9714、-7.6601,all P =0.0000).Conclusions Compared with colostomy technique,the loop ileostomy has advantages including shorter operation time,lower incidence of postoperative complications and quicker recovery after surgery for elderly patients with obstructive sigmoid colon cancer and colorectal cancer.

Late intraocular lens dislocation is one of the most severe late complications after phacoemulsification.It often occurs 3mo after the surgery.Different from early intraocular lens dislocation, late intraocular lens dislocation is caused by zonular dehiscence and contraction of the capsular bag many years after phacoemulsification.In recent years, the incidence of late intraocular lens dislocation gradually increases, having a risk of 0.1% after 10a and 1.7% after 25a.In the long-term follow-up patients who underwent cataract surgery, 90% had zonular insufficiency and capsular contraction.Among the multiple factors which may contribute to zonular weakness and capsular contraction, pseudoexfoliation is the most common cause, accounting for 50% of all the cases.Other risk factors include aging, high myopia, uveitis, trauma, previous vitreoretinal surgery, retinitis pigmentosa, diabetes mellitus, atopic dermatitis, previous acute angle-closure glaucoma attack, and connective tissue disorders.The understanding of these predisposing factors will suggest necessary preventions for high-risk patients in the future.

OBJECTIVE:To prepare the Compound anisodamine and neostigmine sustained-release tablet and study the in vitro drug release behavior. METHODS:Using raceanisodamine and neostigmine methyl sulfate as main medicines,hydroxypropyl meth-yl cellulose as sustained release skeleton material,magnesium stearate as the lubricant,polyvinyl pyrrolidone as the adhesive,pre-gelatinized starch as the thinner,microcrystalline cellulose as the disintegrant and filler,Compound anisodamine and neostigmine sustained-release tablet was prepared by wet granulation method and direct compression method. The in vitro cumulative release rate within 12 h of the 2 main medicines was detected by HPLC method. RESULTS:Compound anisodamine and neostigmine sus-tained-release tablet was successfully prepared,and the in vitro release was basically completed within 12 h,with accumulative re-lease rate of 91.3% for anisodamine and 96.5% for neostigmine. CONCLUSIONS:Compound anisodamine and neostigmine sus-tained-release tablet that can cumulatively release for 12 h is successfully prepared.

Objective: To establish a fast quantitative detection method for tartrazine, sunset yellow, orange Ⅱ sodium salt and allura red in safflower by solid phase extraction-electrospray ionization-high performance ion mobility spectrometry (SPE-ESI-HPIMS).Methods: The pigments were extracted by 70% ethanol with ultrasonic treatment, and then a polyamide SPE column was used to remove the complex matrix interference in safflower.The purified sample was then dissolved in 90% methanol and analyzed under the optimized IMS parameters.Results: The detection time of all the pigments was less than 20 ms.The limit of detection of tartrazine, sunset yellow, orange Ⅱ sodium salt and allura red was 0.17 , 0.15 , 0.30 and 0.25 μg·ml-1 , respectively.All the pigments showed excellent linearity within the range of 0.5-20 μg·ml-1 (r＞0.990 0), the method recovery was 88.0%-98.9% , and the RSD was 1.5%-5.2% (n =6).Conclusion: The method is rapid, simple, highly sensitive and reproducible, and suitable for the rapid quantitative detection of illegal added staining substances in safflower.

Objective To get knowledge of the air pollution situation inside the car caused by the automotive components and decorative materials and the major impacting factors, and to provide the basis for the development of the car air pollution control and countermeasures. Methods Thirty-five cars of different types and ages were selected from January to July 2008. The concentration of benzene series compounds, formaldehyde and TVOC was determined, a survey and analysis of air pollution inside the car was conducted. Results The results showed that the air pollution inside the new cars was serious, with the increase of the using time, the concentration of pollutants reduced. The amount of formaldehyde emission inside the cars was related to the age of the car, the formaldehyde pollution inside the new cars was the most serious in one year. The longer the car was closed, the higher the concentration of pollutants would be. Using perfume or smoking inside the car, car washing or painting could increase the TVOC concentration inside the car. However, after purification treatment, the concentration of air pollutants inside the new cars could significantly decrease. Conclusion The air pollution inside the new cars is so serious, for the health of passengers and drivers, the related standards for the control of the air pollution should be set as soon as possible.

Objective: To explore the dignositic characteristics of coronary heart disease (CHD) in perimenopausal women. Methods: The clinical data of 180 patients suspected of CHD were retrospectively analyzed. The risk factors of CHD,clinical characteristics of chest pain, routine electrocardiography,ambulatory electrocardiography and coronary artery angiography (CAA) were compared between perimenopause group and control group. Results: The incidence of CHD increased significantly in control group(13.5%, 10/76) compared to perimenopause group (43.3%, 45/104, P