Study of 110 pulmonary tuberculosis patients at Hai Phong tuberculosis and lung disease Hospital, the controls was 50 health people from 6/2002 to 2/2003. 36.36% patients have change of disposition; 28.18% patients have obsessional disorder; 4.55% patients which ideology rules over behaviour. 2.73% patients have hallucination of hearing and 1.82% patiens have optical illusion. Depression rate: pulmonary tuberculosis patients was 45.55%, the controls was 14%. Easy depression 32.73%, medium depression 10.91%, heavy depression 0.91%. Anxiety disorder 36.36%
Epidemiology ; Diagnosis ; Tuberculosis, Pulmonary

Introduction of tumor necrosis factor (TNF) inhibitor for the treatment of rheumatoid arthritis (RA) induces not only significant improvement of symptoms and signs of RA but also substantial inhibition of progressive joint damage. Such therapeutic efficacies of TNF inhibitor have led to a paradigm shift in the treatment of RA. In spite of its dramatic effect against RA, it is now well established that the use of TNF inhibitor significantly increases the risk of tuberculosis in patients with RA. Therefore some countries have presented guidelines in the use of TNF inhibitors for rheumatoid arthritis to reduce the risk of tuberculosis. Korea Food and Drug Association (KFDA) have also provided guidelines for treating latent tuberculosis when using TNF inhibitors. In this article, we reviewed the general epidemiology of tuberculosis and incidence rates of tuberculosis in RA patients and those of RA patients treated with TNF inhibitors. We also introduced methods for the diagnosis of latent tuberculosis, and various guidelines published in different countries in managing tuberculosis in RA patients who were to be treated with TNF inhibitors. Finally, we suggest requirement of more appropriate guidelines for Korean RA patients who are candidates for treatment with TNF-inhibitors.
Arthritis, Rheumatoid* ; Diagnosis ; Epidemiology ; Humans ; Incidence ; Joints ; Korea ; Latent Tuberculosis ; Tuberculosis* ; Tumor Necrosis Factor-alpha*

The outcome of screening the household contacts of 49 newly diagnosed tuberculous children as currently practised in the Paediatric Unit of the Port Moresby General Hospital is described. The screening program generated 182 chest X-rays and 67 Mantoux tests. 32 (39%) of 83 child contacts and 11 (11%) of 99 adults were commenced on antituberculous therapy, and 2 children aged 6 months were started on INAH chemoprophylaxis. Adult contacts were identified in 11 (22%) of the 49 families screened. Such a program is an extremely important part of the case management of children with newly diagnosed tuberculosis and their families. PIP: This article describes the outcome of screening the households of 49 children diagnosed with tuberculosis (TB) in the TB section at Port Moresby General Hospital, Nigeria. Household contact screening in a group of 49 children with TB generated a total of 182 chest X-rays and 67 Mantoux tests. 32 children of the 83 screened were given full antituberculosis treatment, and 2 children aged 6 months were given INAH prophylaxis. Furthermore, 11 new adult contacts were diagnosed as new cases of TB. Of the 49 index patients, 30 children had pulmonary TB and 9 had central nervous system, 2 had bone, 2 had miliary, 1 had lymphatic, and 1 had pericardial involvement; 4 children had involvement of more than one site. Thus, the screening program is an extremely important component of the case management of children diagnosed with TB and their families.
Case Management ; Child ; Contact Tracing ; Human ; Mass Screening ; Tuberculosis - diagnosis ; Tuberculosis - epidemiology

The aim of this study was to evaluate the diagnostic value of the cerebrospinal fluid (CSF) T-SPOT.TB test for the diagnosis of TB meningitis (TBM). A retrospective analysis of 96 patients with manifested meningitis was conducted; T-SPOT.TB test was performed for diagnosing TBM to determine the diagnostic sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). A receiver operating characteristic (ROC) curve was also drawn to assess the diagnostic accuracy. The sensitivity, specificity, PPV, and NPV of CSF T-SPOT.TB test were 97.8%, 78.0%, 80.3%, and 97.5%, respectively, for 52 patients (54.2%) of the 96 enrolled patients. The area under the curve (AUC) was 0.910, and the sensitivities of CSF T-SPOT.TB for patients with stages I, II, and III of TBM were 96.7%, 97.2%, and 98.9%, respectively. CSF T-SPOT.TB test is a rapid and accurate diagnostic method with higher sensitivity and specificity for diagnosing TBM.
China ; epidemiology ; Humans ; Sensitivity and Specificity ; Tuberculosis, Meningeal ; cerebrospinal fluid ; diagnosis ; epidemiology

The recovery of nontuberculous mycobacteria (NTM) from respiratory specimens and the number of patients with NTM lung disease have been rapidly increasing in Korea. An early differential diagnosis of NTM lung disease from pulmonary tuberculosis (TB) is important, as the therapeutic regimen differs from that of pulmonary TB, and it is not necessary to track the contacts of patients with NTM lung disease. However, differentiating NTM lung disease from pulmonary TB remains difficult, because the clinical presentations of the two diseases are similar and a definite diagnosis of NTM lung disease based on sputum culture takes time. This review focuses on the changing epidemiology, clinical and radiographic manifestation, and laboratory diagnosis of pulmonary TB and NTM lung disease in Korea.
Clinical Laboratory Techniques ; Diagnosis* ; Diagnosis, Differential ; Epidemiology ; Humans ; Korea ; Lung Diseases* ; Nontuberculous Mycobacteria ; Sputum ; Tuberculosis, Pulmonary*

The recovery of nontuberculous mycobacteria (NTM) from respiratory specimens and the number of patients with NTM lung disease have been rapidly increasing in Korea. An early differential diagnosis of NTM lung disease from pulmonary tuberculosis (TB) is important, as the therapeutic regimen differs from that of pulmonary TB, and it is not necessary to track the contacts of patients with NTM lung disease. However, differentiating NTM lung disease from pulmonary TB remains difficult, because the clinical presentations of the two diseases are similar and a definite diagnosis of NTM lung disease based on sputum culture takes time. This review focuses on the changing epidemiology, clinical and radiographic manifestation, and laboratory diagnosis of pulmonary TB and NTM lung disease in Korea.
Clinical Laboratory Techniques ; Diagnosis* ; Diagnosis, Differential ; Epidemiology ; Humans ; Korea ; Lung Diseases* ; Nontuberculous Mycobacteria ; Sputum ; Tuberculosis, Pulmonary*

Singapore has experienced a rise in the tuberculosis (TB) incidence rate among her local population since 2008, which we believe, is contributed in no small part to a recent increase in community transmission due to delayed diagnosis of infectious pulmonary TB cases. Data from the TB notification registry showed an increase from 2004 to 2008 in the number and proportion of sputum acid-fast bacilli smear-positive pulmonary TB cases with prolonged cough. Two surveys at the TB Control Unit showed that healthcare system delays exceeded patient delay in seeking medical consultation. There is thus an urgent need to heighten TB awareness among the public and the medical community in order to reduce the time taken to diagnose infectious TB cases in Singapore.
Delayed Diagnosis ; Humans ; Incidence ; Infection Control ; methods ; Lung ; diagnostic imaging ; Radiography ; Referral and Consultation ; Singapore ; epidemiology ; Tuberculosis, Pulmonary ; diagnosis ; epidemiology

Until recently, the tuberculin skin test (TST) has been the only tool available for diagnosing a latent TB infection. However, the development of new diagnostic tools, using the Mycobacterium tuberculosis (MTB)-specific early secreted antigenic target 6 (ESAT-6) and culture filtrate protein 10 (CFP-10) antigens, should improve the control of tuberculosis (TB) by allowing a more accurate identification of a latent TB infection (LTBI). Antigen-specific interferon-gamma (IFN-gamma) assays have greater specificity in BCG-vaccinated individuals, and as less biased by nontuberculous mycobacterial infections. Many comparative studies have suggested that those assays have a higher specificity than the TST, and the sensitivity of these assays are expected to remarkably improved if more MTB-specific antigens can become available. Nevertheless, the major obstacle to the widespread use of these tests is the limited financial resources. Similar to other diagnostic tests, the predictive value of IFN-gamma assays depends on the prevalence of a MTB infection in the population being tested. Therefore, prospective studies will be meeded to establish the applicability of these new assays at multiple geographic locations among patients of different ethnicities, and to determine if the IFN-gamma responses can indicate those with a high risk of progressing to active TB.
Bias (Epidemiology) ; Diagnosis* ; Diagnostic Tests, Routine ; Geographic Locations ; Humans ; Interferon-gamma* ; Latent Tuberculosis ; Mycobacterium tuberculosis* ; Mycobacterium* ; Prevalence ; Skin Tests ; Tuberculin ; Tuberculin Test ; Tuberculosis

Although the prevalence of infectious disorders has been decreased, tuberculous infections are still common in this country. Therefore epidemiological data for the correct diagnosis of some spinal infections and proper selection of susceptible antibiotics are necessary. We presented a series of 40 patients with primary spinal infection dated from January 1990 to December 1994. Tuberculosis was the most common infection constituting 85% of this series, while pyogenic infection constituted only 10%, and primary discitis shared 5%. In a half of the tuberculous spondylitis, there were histories of previous tuberculosis except the vertebrae. We could identify the pathogenic organisms in only 47.5% o the cases(in 4 of 6 pyogenic infection and 15 of 34 tuberculous infection). Since it is difficult to differentiate the pyogenic and tuberculous infections by clinical or radiological features alone, some pyogenic infections might have been regarded as tuberculous, although the pyogenic spinal infections are rare. Nevertheless the tuberculous spinal infection outnumbered pyogenic ones in this country, which is similar to the patterns of other third-world countries. Therefore, correct identification of the microbial agent is important not only for the proper treatment but also to evaluate the patients of primary spinal infections in this country.
Anti-Bacterial Agents ; Developing Countries ; Diagnosis ; Discitis ; Epidemiology ; Humans ; Prevalence ; Spine ; Spondylitis ; Tuberculosis

OBJECTIVE: To study the clinical features of METHODS: A retrospective analysis was performed on the medical data of children with immunodeficiency and RESULTS: The onset age in the PID group was significantly lower than those in the control and SID groups ( CONCLUSIONS Children with immunodeficiency and
Age of Onset ; Child ; Humans ; Immunologic Deficiency Syndromes/diagnosis* ; Male ; Retrospective Studies ; Tuberculin Test ; Tuberculosis/epidemiology*