1.Recurrent neutropenia induced by rifabutin in a renal transplant recipient.
Ji Yeun CHANG ; Eun Gyo JEONG ; Ji Hyun YU ; Byung Ha CHUNG ; Chul Woo YANG
The Korean Journal of Internal Medicine 2014;29(4):532-534
No abstract available.
Antibiotics, Antitubercular/*adverse effects
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Female
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Humans
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Kidney Transplantation/*adverse effects
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Middle Aged
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Neutropenia/blood/*chemically induced/diagnosis
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Opportunistic Infections/microbiology/*prevention & control
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Recurrence
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Rifabutin/*adverse effects
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Severity of Illness Index
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Time Factors
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Tuberculosis/microbiology/*prevention & control
2.A Case of Tuberculous Liver Abscess Developed during Chemotherapy for Tuberculous Peritonitis as Paradoxical Response.
Tae Kyung KIM ; Cheol Woong CHOI ; Jong Kun HA ; Hyung Ha JANG ; Su Bum PARK ; Hyung Wook KIM ; Dae Hwan KANG
The Korean Journal of Gastroenterology 2013;62(1):64-68
Tuberculous liver abscesses are rare. Paradoxical response in tuberculosis is common and occurred between 2 weeks and 12 weeks after anti-tuberculous medication. We report here a case of tuberculous liver abscess that developed in a paradoxical response during chemotherapy for tuberculous peritonitis in a 23-year-old male. He was hospitalized, complaining of ascites, epigastric pain. He was diagnosed tuberculous peritonitis by expiratory laparoscopic biopsy and took medication for tuberculosis. After 2 months, a hepatic lesion was detected with CT scan incidentally. Chronic granulomatous inflammation was seen in ultrasound-guided liver biopsy, and tuberculous liver abscess was diasnosed. It was considered as paradoxical response, rather than treatment failure or other else because clinical symptoms of peritoneal tuberculosis and CT scan improved. After continuing initial anti-tuberculous medication, he was successfully treated. Herein, we report a case of tuberculous liver abscess as paradoxical response while treating peritoneal tuberculosis without changing anti-tuberculous treatment regimen.
Antitubercular Agents/*adverse effects/*therapeutic use
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DNA, Bacterial/analysis
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Humans
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Laparoscopy
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Liver/pathology/ultrasonography
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Liver Abscess/*chemically induced/*diagnosis/microbiology
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Male
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Mycobacterium tuberculosis/genetics/isolation & purification
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Necrosis/pathology
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Peritoneum/pathology
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Peritonitis, Tuberculous/*drug therapy
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Tomography, X-Ray Computed
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Tuberculosis/*diagnosis/microbiology
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Young Adult
3.Imatinib mesylate-induced interstitial lung disease in a patient with prior history of Mycobacterium tuberculosis infection.
Na Ri LEE ; Ji Won JANG ; Hee Sun KIM ; Ho Young YHIM
The Korean Journal of Internal Medicine 2015;30(4):550-553
No abstract available.
Adult
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Antineoplastic Agents/*adverse effects
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Antitubercular Agents/therapeutic use
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Biopsy
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Female
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Gastrointestinal Stromal Tumors/*drug therapy/pathology/surgery
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Humans
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Imatinib Mesylate/*adverse effects
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Lung Diseases, Interstitial/*chemically induced/diagnosis
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Mycobacterium tuberculosis/*isolation & purification
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Protein Kinase Inhibitors/*adverse effects
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Rectal Neoplasms/*drug therapy/pathology/surgery
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Tomography, X-Ray Computed
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Tuberculosis, Pulmonary/diagnosis/drug therapy/*microbiology
4.Safe Re-administration of Tumor Necrosis Factor-alpha (TNFalpha) Inhibitors in Patients with Rheumatoid Arthritis or Ankylosing Spondylitis Who Developed Active Tuberculosis on Previous Anti-TNFalpha Therapy.
Young Sun SUH ; Seung Ki KWOK ; Ji Hyeon JU ; Kyung Su PARK ; Sung Hwan PARK ; Chong Hyeon YOON
Journal of Korean Medical Science 2014;29(1):38-42
There is no consensus on whether it is safe to re-administer tumor necrosis factor-alpha (TNFalpha) inhibitors in patients with rheumatoid arthritis (RA) or ankylosing spondylitis (AS) flared after withdrawal of TNFalpha inhibitors due to active tuberculosis (TB). We evaluated the safety of restarting anti-TNFalpha therapy in patients with TNFalpha-associated TB. We used data of 1,012 patients with RA or AS treated with TNFalpha inhibitors at Seoul St. Mary's Hospital between January 2003 and July 2013 to identify patients who developed active TB. Demographic and clinical data including the results of tuberculin skin tests (TST) and interferon-gamma releasing assays (IGRA) were collected. Fifteen patients developed active TB. Five cases were occurred in RA and 10 cases in AS. Nine of 15 patients had a negative TST or IGRA and 6 TST-positive patients had received prophylaxis prior to initiating anti-TNFalpha therapy. All patients discontinued TNFalpha inhibitors with starting the treatment of TB. Eight patients were re-administered TNFalpha inhibitors due to disease flares and promptly improved without recurrence of TB. TNFalpha inhibitors could be safely resumed after starting anti-TB regimen in patients with RA or AS.
Adult
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Aged
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Anti-Inflammatory Agents, Non-Steroidal/adverse effects/therapeutic use
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Antibodies, Monoclonal/adverse effects/therapeutic use
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Antibodies, Monoclonal, Humanized/adverse effects/therapeutic use
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Antirheumatic Agents/adverse effects/therapeutic use
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Arthritis, Rheumatoid/*drug therapy
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Enzyme Inhibitors/adverse effects/therapeutic use
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Female
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Humans
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Hydroxychloroquine/adverse effects/therapeutic use
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Immunoglobulin G/adverse effects/therapeutic use
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Immunosuppressive Agents/adverse effects/*therapeutic use
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Interferon-gamma Release Tests
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Male
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Methotrexate/adverse effects/therapeutic use
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Middle Aged
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Mycobacterium tuberculosis/isolation & purification
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Receptors, Tumor Necrosis Factor/therapeutic use
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Retrospective Studies
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Spondylitis, Ankylosing/*drug therapy
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Tuberculin Test
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Tuberculosis/*chemically induced/microbiology
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Tumor Necrosis Factor-alpha/*antagonists & inhibitors