No abstract available.
Drug Therapy* ; Tuberculosis, Pulmonary*

Tuberculous cavity is important in diagnosis and observation in the course of pulmonary tuberculosis. Authoranalyzed the radiologic findings of cavity and average months of negative conversion in AFB culture in 89 cases ofinitial treatment. The results were as follows: 1. The more number of cavities, the longer period in negativeconversion of AFB culture. 2. No relation between sums of diameter and thickeness of cavity and average months ofnegative conversion in AFB cultlure. 3. In the cases of cavity with air-fluid level took longer period in negativeconversion of AFB culture than those of cavity without air-fluid level, significantly. 4. No relation betweenradiologic findings of cavity and results of chemotherapy for pulmonary tuberculosis.
Diagnosis ; Drug Therapy ; Tuberculosis, Pulmonary

The preliminary results showed that the immunotherapy with M.Vaccae may be very effective. 13 of 20 patients without immunotherapy (group A) have improved clinically, comparing with 22 improved patients of 22 patients with immunotherapy (group B), especially, 4 of 20 patients in group A had a relapse after treatment, and the difference of immune responses between 2 groups in the end of treatment could be found out.
Tuberculosis, Pulmonary ; Immunotherapy ; Drug Therapy ; Diagnosis

Numerous problems has not been solved in the field of pulmonary tuberculosis, especially in chemotherapy. There has been many turning points in the treatment of pulmonary tuberculosis such as; introduction of streptomycin, combination therapy, isoniazid single therapy, intermittent chemotherapy, and recent short-term chemotherapy. It is very important to know about individual drugs for the better chemotherapy. So a review has been made referring many literatures in pharmacologic properties of them. Also single INH therapy, double chemotherapy and triple chemotherapy have be described.
Drug Therapy* ; Isoniazid ; Streptomycin ; Tuberculosis, Pulmonary

No abstract available.
Drug Therapy* ; Family Practice* ; Humans ; Tuberculosis, Pulmonary*

BACKGROUND: Interferon-gamma (IFN-g) and tumor necrosis factor-alpha (TNF-a) play a critical role in protective immunity against Mycobacterium tuberculosis infection. (The change )of IFN-g and TNF-a producing capacity in the course of antituberculous chemotherapy in patients with pulmonary tuberculosis (was evaluated in this study.) METHOD: In 29 patients with pulmonary tuberculosis, phytohemagglutinin(PHA) or purified protein derivative(PPD) stimulated production of IFN-g and TNF-a by peripheral blood mononuclear cells was quantified. Five patients were sampled before they underwent antituberculous treatment, 11 patients after 0 -4 months, six after 4 -completion and seven after treatment completion. RESULT: There was no difference in PHA- or PPD- stimulated production of IFN-g and TNF-a between each group. CONCLUSION: No difference in PHA- or PPD- stimulated production of IFN-g and TNF-a between two groups could be identified during classification of patients with pulmonary tuberculosis by their treatment stages.
Classification ; Drug Therapy* ; Humans ; Interferon-gamma ; Mycobacterium tuberculosis ; Tuberculosis ; Tuberculosis, Pulmonary* ; Tumor Necrosis Factor-alpha

These days, genitourinary tuberculosis (GUTB) rarely occurs in conjunction with pulmonary tuberculosis. Reconstructive surgery for GUTB has also decreased but may still be done in case of a grossly distorted genitourinary anatomy and dysfunction that are unlikely to regress with chemotherapy alone. Reconstructive bladder surgery for GUTB is a well-established procedure. The various complications associated with the reconstructive surgery have also been well documented. We present a case of an uncommon complication after ileocystoplasty.
Drug Therapy ; Tuberculosis* ; Tuberculosis, Pulmonary ; Tuberculosis, Urogenital ; Urinary Bladder* ; Urinary Diversion

Intestinal tuberculosis presents with nonspecific and variable clinical manifestations. It is rarely seen in current clinical practice and the diagnosis may be missed or confused with many other disorders such as Crohns disease and intestinal neoplasms. The route of infection by tuberculous enteritis is variable and the treatment regimens used for treating pulmonary tuberculosis are generally effective for tuberculous enteritis as well. Uncomplicated tuberculous enteritis can be managed with a nine to 12- month course of antituberculous chemotherapy. If not treated early, the prognosis for intestinal tuberculosis is poor, with an overall mortality of between 19 percent and 38 percent. However, 90 percent of patients will respond to medical therapy alone if started early. Therefore, early detection and treatment is essential. Here we report a case of intestinal tuberculosis secondary to miliary tuberculosis.
Crohn Disease ; Diagnosis ; Drug Therapy ; Enteritis ; Humans ; Intestinal Neoplasms ; Mortality ; Prognosis ; Tuberculosis* ; Tuberculosis, Miliary* ; Tuberculosis, Pulmonary

A study was carried out in 81 retreatment patients with sputum positive pulmonary tuberculosis who had previously been treated with first-line drugs for more than one year at Health Center. The Fallowing results were obtained; 1. Of the total 81 case of retreatment patients, male patients occupied 63(77.8%) and 18(22.20%a) were female. Age group of 30-,-49 years was 54.3% of total cases. 2. By extent of disease, moderate advanced cases were 53.1% and far advanced cases were 35.8%. 3. Of 81 patients admitted to the study, 65(80.3%) completed 1 year treatment 16(19.7%) patients discharged prematurely before 1 year. 4 patients terminated their treatment during 9-11 months after registration. 4. Completment rate of chemotherapy was highest (90%) at age of under'. 30 years. 5. Intractable patients with persistant positive sputum test for A.F.B. even after 12 months of retreatment were occupied 9(13.8%) of total retreatment cases.
Drug Therapy ; Female ; Humans ; Male ; Retreatment* ; Sputum ; Tuberculosis, Pulmonary*

This study was performed for the comparison of the therapeutic efficiency between 6-month (2tHER/4HER) and 9-month (9HER) short-course chemotherapy under the programe conditions for pulmonary tuberculosis in terms of sputum AFB negative conversion rate, remedial interruption rate and cost effectiveness analysis. Two hundreds and ninty three patients treated with 9HER and 641 treated with 2HERZ/4HER had been discharged from 22 health centers in Seoul from May 1, 1993 to April 30, 1994. Seven hundreds and seventeen was subsequently analysed excluding 217 patients due to remedial interruption. The results: 1. Bacteriological negative conversion rate in 9HER regimen and 2HERZ/4HER regimen was 97.8% and 96.4% respectively (p>0.05). But the early treatment period, negative conversion rate in 2HERZ/4HER regimen was very higher than in 9HER regimen(p<0.01). 2. Remedial interruption rate for 9HER regimen and 2HERZ/4HER regimen was 34.1% and 13.6% respectively. The primary reason for the interruption was transfering to other clinics and this interruption was high within 3months. 3. Cost effectiveness for 2HERZ/4HER regimen was higher than 9HER regimen. The difference cost effectiveness ratio was 2.33 at the first sputum test and 1.69 at the last sputum test.
Cost-Benefit Analysis ; Drug Therapy* ; Humans ; Seoul* ; Sputum ; Tuberculosis, Pulmonary*