Study of 110 pulmonary tuberculosis patients at Hai Phong tuberculosis and lung disease Hospital, the controls was 50 health people from 6/2002 to 2/2003. 36.36% patients have change of disposition; 28.18% patients have obsessional disorder; 4.55% patients which ideology rules over behaviour. 2.73% patients have hallucination of hearing and 1.82% patiens have optical illusion. Depression rate: pulmonary tuberculosis patients was 45.55%, the controls was 14%. Easy depression 32.73%, medium depression 10.91%, heavy depression 0.91%. Anxiety disorder 36.36%
Epidemiology ; Diagnosis ; Tuberculosis, Pulmonary

OBJECTIVETo describe the geographical distribution regarding the prevalence rates of pulmonary tuberculosis (TB) in 2010, to provide reference for eliminating the regional unbalance of TB prevalence in China.

METHODSThiessen Polygon Method, dealing with spatial analysis in geographical information system, was used to analyze data from the 5th national TB epidemiological survey.

RESULTSThe prevalence rates of active pulmonary TB(PAPT), Mycobacterium-positive pulmonary TB (PMPT) and smear-positive pulmonary TB (PSPT) were 62-548/100 thousand population (OHTP),0-120/OHTP and 0-68/OHTP, which were all relatively lower in most parts of Beijing, Tianjin, Hebei, Shanghai, Jiangsu, Zhejiang and Shandong than in other areas. PAPT (549-1656/OHTP), PMPT (121-366/OHTP) and PSPT (69-181/OHTP) were relatively higher in most parts of Guangxi, Sichuan, Guizhou, Yunnan, Xizang, Qinghai and Xinjiang than in other areas, in which PAPT, PMPT and PSPT of some areas could be seen as high as 1657-2646/OHTP, 367-625/OHTP and 182-285/OHTP, respectively. PAPT, PMPT and PSPT manifested jigsaw pattern distribution between 320-548/OHTP adn 549-919/OHTP, among 67-120/OHTP, 121-207/OHTP and 208-366/OHTP, and among 38-68/OHTP, 69-115/OHTP and 116-181/OHTP, respectively, in the rest of the provinces or autonomous regions.

CONCLUSIONThe geographical distribution for TB prevalence significantly presented the fact that it was relatively low in the eastern parts and high in the western parts, and a jigsaw transition pattern between the low and high rates, in the central part of the country.

Objective: To analyze the epidemic characteristics and drug resistance of pulmonary tuberculosis among the floating population in Beijing and to provide a scientific basis for formulating strategies for the prevention and control of tuberculosis among the floating population. Methods: Data of tuberculosis patients who were positive for Mycobacterium tuberculosis culture was collected from 16 districts and one municipal institution of tuberculosis control and prevention in Beijing in 2019. The strain samples were tested for drug sensitivity by the proportional method. According to household registration location, patients were divided into the floating population and Beijing registration. SPSS 19.0 software analyzed tuberculosis patients' epidemic characteristics and drug resistance in the floating population. Results: In 2019, there were 1 171 culture-positive tuberculosis patients in Beijing, among the floating population, 593 (50.64%) patients were identified, with a male-to-female sex ratio of 2.2∶1 (409∶184). Compared to patients under household registration as Beijing residents, a higher proportion of young adults aged 20-39 years (65.09%,386/593) were noticed, with 55.65% (330/593) reported from the urban areas and 96.80% (574/593) were reported the first time. The differences were statistically significant (all P<0.05). After completing the drug sensitivity test, 37 cases were with multiple drug-resistant tuberculosis, accounting for 6.24% (37/593). The rates of isoniazid resistance (42.11%,8/19) and multidrug resistance (21.05%,4/19) in floating population patients after retreatment were significantly higher than those in newly treated patients (11.67%, 67/574 and 5.75%, 33/574), and the differences were statistically significant (all P<0.05). Conclusions: Most patients with tuberculosis in the floating population in Beijing in 2019 were young males aged 20-39 years. The reporting areas were urban areas and the newly treated patients mainly. The patients with tuberculosis in the re-treated floating population were more likely to suffer from multidrug and drug resistance, which should be taken as the key population for prevention and control.
Young Adult ; Humans ; Female ; Male ; Beijing/epidemiology* ; Tuberculosis ; Tuberculosis, Pulmonary/epidemiology* ; Tuberculosis, Multidrug-Resistant/epidemiology* ; Drug Resistance

Objective: To analyze the medical care seeking of local and non-local pulmonary tuberculosis (TB) patients in Beijing from 2016 to 2021 and provide evidence for TB prevention and control in Beijing. Methods: The reported pulmonary TB data from 2016 to 2021 were collected from tuberculosis management information system and standard code management system of Chinese information system for disease control and prevention. The map data were obtained from the Institute of Geographic Sciences and Natural Resources Research. Excel 2016, SPSS 19.0, Python 3.9 and ArcGIS 10.6 softwares were used for data analysis and visualization for the inter-provincial mobility and inter-district mobility of pulmonary TB patient's medical care seeking in Beijing. Results: Among the reported pulmonary TB patients in Beijing from 2016 to 2021, 35.27%(24 307/68 926) were from 30 provinces (autonomous regions, municipalities) and Xinjiang Production and Construction Corps. The top 5 provinces with pulmonary TB patients medical care seeking in Beijing were Hebei (39.58%,9 620/24 307), Shanxi (8.82%,2 145/24 307), Inner Mongolia Autonomous Region (8.66%,2 105/24 307), Heilongjiang (6.95%,1 690/24 307) and Henan (6.88%,1 672/24 307). Patients from these 5 provinces accounted for 70.89% (17 232/24 307) of total pulmonary TB patients from other provinces. The pulmonary TB patients from other provinces mainly flowed to Tongzhou district of Beijing, accounting for 46.72% (11 356/24 307). These pulmonary TB patients mainly visited grade Ⅲ (A) hospitals, such as Beijing Chest Hospital of Capital Medical University with the highest proportion of 44.76% (10 880/24 307). Among pulmonary TB patients with current residence in Beijing, those sought medical care in other districts accounted for 55.06% (24 566/44 619). The outflow and inflow of TB cases' medical care seeking occurred in 16 districts of Beijing. The median proportion of cross district medical care seeking in 16 districts was 59.30% (56.05%, 65.13%). The inflow of the medical care seeking in Tongzhou, Haidian and Xicheng district was greater than the outflow, and the outflow was greater than the inflow in the other 13 districts. The pulmonary TB patients in Beijing mainly went to Beijing Chest Hospital in Tongzhou for medical care seeking, accounting for 42.18%(18 822/44 619). Conclusions: The proportions of non-local pulmonary TB patients seeking medical care in Beijing from 2016 to 2021 and local pulmonary TB patients seeking medical care in other districts in Beijing were high, and the hospitals where non-local pulmonary TB patients and local pulmonary TB patients sought medical care respectively belonged to grade Ⅲ (A) and municipal designated medical institutions of TB.
Humans ; Tuberculosis, Pulmonary/therapy* ; Hospitals ; Asian People ; China/epidemiology* ; Chlorhexidine

Adult ; China ; epidemiology ; Female ; Gonorrhea ; epidemiology ; Hepatitis, Viral, Human ; epidemiology ; Humans ; Incidence ; Male ; Middle Aged ; Syphilis ; epidemiology ; Tuberculosis, Pulmonary ; epidemiology

Objective: To compare the characteristics of children's pulmonary tuberculosis (PTB) cases reported from 2019 to 2021 before and during the implementation of the Action Plan to Stop Tuberculosis. Methods: Based on the reported incidence data and population data of child pulmonary tuberculosis (PTB) notified to the Chinese Center for Disease Control and Prevention (CDC) Tuberculosis Information Management System (TBIMS) from 2019 to 2021, the population information and clinically relevant information in different years were compared. Results: From 2019 to 2021, the reported cases of PTB in children were 363, 664 and 655, respectively. The number of reported cases increased significantly. The median age of the cases in children increased from 10.4 years in 2019 to 11.7 years in 2021 (P=0.005) over a three-year period. The etiological positive rate increased significantly from 11.6% (42/363) in 2019 to 32.2% (211/655) in 2021 (P<0.001). The positive rate of molecular testing increased most significantly, which became the main means of etiological detection and accounted for 16.7% (7/42), 62.0% (57/92) and 75.4% (159/211) of the children with positive etiological results, respectively. The resistance rates of isoniazid and rifampicin were analyzed in children with PTB who underwent drug sensitivity tests. The results showed that the resistance rates of isoniazid and/or rifampicin were 2/9, 3.9% (2/51) and 6.7% (11/163), respectively, with an average of 6.7% (15/223) over three years. The median patients' delay was 27 (12, 49) days in 2019. It was reduced to 19 (10, 37) days in 2020 and 15 (7, 34) days in 2021, both significantly lower than 2019 (P=0.009 and 0.000 2, respectively). Conclusion: From 2019 to 2021, the reported numbers of children with PTB and children with positive etiological results increase significantly in Liangshan Prefecture, while the diagnosis delay of patients significantly reduces.
Humans ; Child ; Rifampin/therapeutic use* ; Isoniazid/therapeutic use* ; Tuberculosis, Pulmonary/drug therapy* ; Tuberculosis ; China/epidemiology*

Objective: To compare the characteristics of children's pulmonary tuberculosis (PTB) cases reported from 2019 to 2021 before and during the implementation of the Action Plan to Stop Tuberculosis. Methods: Based on the reported incidence data and population data of child pulmonary tuberculosis (PTB) notified to the Chinese Center for Disease Control and Prevention (CDC) Tuberculosis Information Management System (TBIMS) from 2019 to 2021, the population information and clinically relevant information in different years were compared. Results: From 2019 to 2021, the reported cases of PTB in children were 363, 664 and 655, respectively. The number of reported cases increased significantly. The median age of the cases in children increased from 10.4 years in 2019 to 11.7 years in 2021 (P=0.005) over a three-year period. The etiological positive rate increased significantly from 11.6% (42/363) in 2019 to 32.2% (211/655) in 2021 (P<0.001). The positive rate of molecular testing increased most significantly, which became the main means of etiological detection and accounted for 16.7% (7/42), 62.0% (57/92) and 75.4% (159/211) of the children with positive etiological results, respectively. The resistance rates of isoniazid and rifampicin were analyzed in children with PTB who underwent drug sensitivity tests. The results showed that the resistance rates of isoniazid and/or rifampicin were 2/9, 3.9% (2/51) and 6.7% (11/163), respectively, with an average of 6.7% (15/223) over three years. The median patients' delay was 27 (12, 49) days in 2019. It was reduced to 19 (10, 37) days in 2020 and 15 (7, 34) days in 2021, both significantly lower than 2019 (P=0.009 and 0.000 2, respectively). Conclusion: From 2019 to 2021, the reported numbers of children with PTB and children with positive etiological results increase significantly in Liangshan Prefecture, while the diagnosis delay of patients significantly reduces.
Humans ; Child ; Rifampin/therapeutic use* ; Isoniazid/therapeutic use* ; Tuberculosis, Pulmonary/drug therapy* ; Tuberculosis ; China/epidemiology*

Since the diagnosis of extrapulmonary tuberculosis (EPT) is largely depended on the physician's suspicion in respect of the disease, we believed that it would be worthwhile to scrutinize the clinical characteristics of EPT. Thus, here we present retrospectively evaluated clinical manifestations of patients who were diagnosed as EPT cases in a tertiary referral care hospital. Medical records of 312 patients, diagnosed as having EPT at Yongdong Severance hospital from January 1997 to December 1999, were reviewed retrospectively. In total 312 patients, 149 (47.8%) males and 163 (52.2%) females aged from 13 years to 87 years, were included into this study. The most common site of the involvement was pleura (35.6%). The patients complained of localized symptoms (72.4%) more frequently than systemic symptoms (52.2%). The most common symptom was pain at the infected site (48.1%). Leukocytosis, anemia, and elevated erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were found in 12.8%, 50.3%, 79.3% and 63.1% of the patients, respectively. Twenty-four percent of the patients had underlying medical illnesses such as, diabetes mellitus or liver cirrhosis, or were over 60 years old. In 67.3% of patients, tuberculosis was suspected at the initial visit. However, tuberculosis was microbiologically proven in only 23.7% of the patients. The time interval from the symptom onset to the diagnosis varied, with the mean duration of the period 96 days. Pulmonary parenchymal abnormal lesions were found in 133 patients (42.6%) on chest radiographs. EPT has a wide spectrum of clinical manifestations, so it is difficult to diagnose it. Based on our studies, only 11.2% of the patients were confirmed as EPT. So it is important that the physician who first examines the patient should have a high degree of suspicion based on the chest radiography, localized or systemic symptoms and several laboratory parameters reviewed in this study.
Adolescent ; Adult ; Aged ; Biopsy ; Female ; Human ; Incidence ; Male ; Middle Aged ; Prevalence ; Retrospective Studies ; Tuberculosis/*epidemiology/*pathology/radiography ; Tuberculosis, Lymph Node/epidemiology/pathology/radiography ; Tuberculosis, Osteoarticular/epidemiology/pathology/radiography ; Tuberculosis, Pleural/epidemiology/pathology/radiography ; Tuberculosis, Pulmonary/epidemiology/pathology/radiography

OBJECTIVETo understand the spatial-temporal specific incidence of pulmonary tuberculosis (TB) in Gansu.

METHODSThe county-based incidence of pulmonary TB in Gansu from 2009 to 2013 was used to calculate Moran's I and G statistics, and analyze the spatial-temporal distribution of areas with different pulmonary TB incidences.

RESULTSThe spatial correlation in incidence of pulmonary TB was found in Gansu from 2009 to 2013 (P<0.001), and the hot spot areas were mainly in Hexi area, Linxia, part of Dingxi, while the cold spot areas were in Lanzhou, part of Dingxi, Tianshui, Pingliang and Qingyang. Spatial-temporal analysis showed that the clustering of high pulmonary TB incidence areas were most likely in the Hexi area during 2009-2010 (LLR=3,031.10, RR=2.27, P<0.001), and the clustering of low pulmonary TB incidence areas were most likely in Lanzhou during 2011-2013 (LLR=1,545.52, RR=0.37, P<0.001).

CONCLUSIONThe analysis on spatial and spatial-temporal specific incidences of pulmonary TB in Gansu from 2009 to 2013 indicated that Hexi area is the key area in pulmonary TB prevention and control in Gansu.

China ; epidemiology ; Humans ; Patient Acceptance of Health Care ; Tuberculosis, Pulmonary ; epidemiology ; psychology