1.Advances in research on molecular biological markers for the differential diagnosis of thyroid neoplasms
Tuanqi SUN ; Yi WU ; Zhuoying WANG
China Oncology 2001;0(02):-
Thyroid neoplasm is one of the most common endocrinal tumors. In general, thyroid cancer patients are usually presented with asymptomatic neck nodules. A differential diagnosis between malignant and benign thyroid neoplasm is very important for these patients. This review article primarily discusses biological markers used to aid the differential diagnosis of thyroid neoplasia, which may lead to a more rational approach to the treatment. It mainly describes the recent development of molecular biological markers VEGF-C, Cytokeratin-19, HBME-1, Pax8-PPAR and Galectin-3 for the differential diagnosis of thyroid neoplasms.
2. Retrospective comparison of screening criteria for active surveillance for papillary thyroid microcarcinoma
Kai QIAN ; Tuanqi SUN ; Kai GUO ; Xiaoke ZHENG ; Duanshu LI ; Wenjun WEI ; Yi WU ; Qinghai JI ; Zhuoying WANG
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2017;52(6):430-434
Objective:
To investigate the rationality of management of active surveillance for papillary thyroid microcarcinoma (PTMC) and the main indications for active surveillance for PTMC.
Methods:
In this study, two criteria were used to evaluate patients with PTMC: low-risk PTMC conditions defined by Kuma hospital and Chinese Association of Thyroid Oncology (CATO) consensus on PTMC management of active surveillance. The patients had received surgical treatment. Clinicopathological characteristics and prognosis of the patients in different groups were compared.
Results:
A total of 778 patients were enrolled in the study, 565 (72.6%) of them met Kuma screening criteria and only 112 (14.4%) met CATO screening criteria. Kuma low-risk subgroup had lower incidence of cervical lymph node metastasis than Kuma high-risk PTMC subgroup(30.6%