Objective To detect the level of interleukin(IL)-12 and IL-10 in the serum patients with progressive psoriasis vulgaris and to investigate the role them. Methods The serum samples were collected from 10 patients with progressive psoriasis vulgaris. The levels of IL-12 and IL-10 in the serum both the patients and health controls were detected by ELISA. Results IL-12 level increased significantly and IL-10 decreased remarkably in the patients compared with the control. Conclusion IL-12 and IL-10 play an important role in pathogenesis of psoriasis vulgaris.