1.Sunlight Exposure and Breast Density: A Population-Based Study.
Sheng Hui WU ; Suzanne C HO ; Edwin SO ; Tsz Ping LAM ; Jean WOO ; P Y YUEN ; Ling QIN ; Susanna KU
Journal of Breast Cancer 2013;16(2):171-177
PURPOSE: This study aims to assess the association of sunlight exposure with breast cancer risk, measured by the breast density assessed from Tabar's mammographic pattern in Chinese women. METHODS: A total of 676 premenopausal women were recruited to participate in this study, in which 650 completed a validated sunlight exposure questionnaire via telephone. The mammograms were classified according to Tabar's classification for parenchyma, and patterns IV & V and I, II & III indicated respectively high and low risk mammographic patterns for breast cancer. The odds ratios (OR) and 95% confidence intervals (CIs) for sun exposure-related variables were estimated using unconditional logistic regression with adjustment for potential confounders. RESULTS: Among 646 participants, women with high breast cancer risk (Tabar's patterns IV &V) had less hours spent in the sun than those with low risk (I, II & III) at any age stage. A higher level of sunlight exposure was associated with a significantly lower risk having high risk Tabar's pattern. Women aged 40 to 44 years who were in the highest tertile of lifetime total hours spent in the sun had a multi-adjusted OR of 0.41 (95% CI, 0.18-0.92; p for trend=0.03) compared with those in the lowest tertile (>2.19 hr/day vs. <1.32 hr/day). For hours spent in the sun across the ages of 6 to 12 years, the comparable OR was 0.37 (95% CI, 0.15-0.91; p for trend=0.03). CONCLUSION: These findings suggest that higher sunlight exposure is related to a lower risk of having high risk breast density pattern in premenopausal women. Our results also suggest the most relevant period of exposure is during earlier life.
Aged
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Asian Continental Ancestry Group
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Breast
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Breast Neoplasms
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Female
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Humans
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Logistic Models
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Mammary Glands, Human
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Odds Ratio
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Solar System
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Sunlight
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Telephone
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Vitamin D
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Surveys and Questionnaires
2.Abnormal Activity of Sympathetic Nervous System in Girls with Adolescent Idiopathic Scoliosis: A Cross-sectional Study.
Zong Shan HU ; Zhi Hui ZHAO ; Chang-Chun TSENG ; Jie LI ; Gene Chi-Wai MAN ; Tsz-Ping LAM ; Yong QIU ; Chun-Yiu Jack CHENG ; Ze Zhang ZHU ; Zhen LIU
Biomedical and Environmental Sciences 2018;31(9):700-704