1. STUDY ON PARAMETERS OF PERSONALITY CHANGES OF CHILDREN WHO LINE IN RESIDENTIAL SERVICES
Nyamtsetseg J ; Gantsetseg T ; Tuya B ; Enkhtaivan B ; Uyanga G ; Tsogzolmaa D
Innovation 2015;9(1):46-49
In pathopsychology, one branch of mental analysis, recently we are using qualitative analyzing methods for mental phenomena. But improvement of professional methods of study, generalization of the new computer based technology, children’s psychology assessment and many other problems are becoming an urgent issue in this field.Our study involved 45 children from orphanage and the High School Personality Questionnaire (HSPQ) computer based questionnaire is used to measure the personality characteristics of orphan children. Spielberg-Hanin test is used to reveal anxiety. Study is analyzed by SPSS program.In total, 45 children (age from 9 to 18), 22 boys and 23 girls participated in our survey. 8.9% of them measured as a high intelligence, 91.1% measured as a lower and an average intelligence. Interestingly, 60% of children were good at controlling their emotions and behavior. Thus 55.6%had symptoms of flexible mind, imagining and probability of affect illness. Having more stress is due to introverted preference and self-blaming, also a feeling of self-blaming is due to not being bold. 51.1% of them assessed that they have dependent, emulative personality and submissive behavior which was very considerably. The anxiety of condition was high in 34.1% of children andlow in 12.2% of them, thus anxiety of individual was high in 36.6% and low in 7.3% of children. Therefore, it’s essential to help orphan children and consider reducing anxiety and improving their self-independence.
2.Trends Of The Prevalence And Treatment Of Hypertension Among Mongolian Populiation In 2005-2009
Narantuya D ; Otgontuya D ; Tsogzolmaa B ; Bolormaa I ; Dejeekhuu G
Journal of Oriental Medicine 2013;8(2):44-44
Study objective is to determine the mean systolic blood pressure (SBP) and
diastolic blood pressure (DPB), prevalence of hypertension (HTN), treatment status,
and respective trends in Mongolian population during 2005-2009.Two independent
cross-sectional population-based surveys were carried out in 2005 and 2009 to
monitor cardiovascular risk factors in men and women aged 15-64 years. The
surveys were conducted according to the WHO STEP wise approach.
3.A study of tissue biomarkers in gastric cancer and its precursors
Nyam-Erdene N ; Tsogzolmaa Sh ; Batchimeg B ; Nomin-Erdene D ; Tuul B ; Оyunbileg N ; Zorigoo Sh ; Ganchimeg D ; Munkhbayar S ; Baasanjav N ; Tulgaa L
Mongolian Medical Sciences 2024;209(3):21-28
Background:
Specifically, stomach cancer ranks as the fifth leading cause of cancer morbidity
and mortality worldwide. Early-stage detection significantly improves survival rates,
with over 90% of patients diagnosed at stages I and II living beyond five years. To
improve the early detection of gastric cancer, it is necessary to complement the
conventional method of endoscopic examination with biomarker analysis. We aimed
to compare biomarkers such as pepsinogen C (PGC), matrix metalloproteinase 2
(MMP2), matrix metalloproteinase 9 (MMP9), and the cell proliferation marker Ki-67
with immunohistochemical analysis.
Purpose:
A comparative study and evaluation of biomarkers for the early detection of gastric
cancer.
Materials and Methods:
The study was conducted using a retrospective cohort design. Research ethics
issues were discussed at the meeting of the Medical Ethics Control Committee of
the Ministry of Health on October 13, 2023, and permission to start the research
was obtained (Resolution No. 23/051). The information was gathered based on the
criteria for K29.3, K29.4, K31, and C1 diagnoses according to the international ICD
10 classification, and participants were selected accordingly. Proteins such as PGC,
MMP2, MMP9, and Ki-67 were examined using a tissue microarray kit and evaluated
through immunohistochemical analysis.
Results:
Negative gastric tumor markers PGC, Ki-67, MMP2 and MMP9 were evaluated
by immunohistochemical analysis. The mean PGC protein staining values were
6.20±2.61 for chronic superficial gastritis, 5.45±2.47 for atrophic gastritis, 3.61±2.0 for
metaplasia, and 3.31±1.75 for gastric cancer, with statistically significant differences
between the groups (P<0.001). The mean Ki-67 protein staining values were 0.1 ±
0.4 for chronic superficial gastritis, 0.33 ± 0.55 for atrophic gastritis, 0.09 ± 0.39 for
metaplasia, and 2.62 ± 0.78 for gastric cancer, also showing statistically significant
differences (P<0.001). The mean MMP2 and MMP9 protein staining values were
0.2±0.76 and 1.2±2.04, respectively, for chronic superficial gastritis; 0.28±0.52
and 3.28±2.82 for atrophic gastritis; 0.35±1.04 and 1.12±1.45 for metaplasia; and
1.38±2.11 and 5.29±2.51 for gastric cancer, with all differences being statistically
significant (P<0.001).
Conclusion
PGC protein, a negative tumor marker, decreases during the transition
from a gastric cancer precursor to cancer. MMP2 protein, a marker of cell migration
and metastasis, has little diagnostic value, while the expression of MMP9 and the Ki
67 are highly effective in gastric cancer. Immunohistochemical analysis of endoscopic
biopsy tissue to detect the negative tumor marker PGC, the positive marker Ki-67,
and MMP9 can be used for early detection of gastric cancer.